1993
DOI: 10.1001/archpsyc.1993.01820130009002
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Quantitative Cerebral Anatomy in Depression

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Cited by 425 publications
(43 citation statements)
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“…Smaller brain volumes and larger high intensity lesion volumes have been demonstrated in patients with major depression when compared with controls (28,(31)(32)(33)(34). The atrophy demonstrated in patients with MDD by using MRI is more pronounced in, but not restricted to, the prefrontal lobe (28,33). Earlier findings from our laboratory indicate that an increase in cerebrospinal fluid volume (serving as an indirect measure of atrophy) and overall medical burden, increases the odds ratio for the prevalence of existing MDD (28,57).…”
Section: Discussionmentioning
confidence: 72%
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“…Smaller brain volumes and larger high intensity lesion volumes have been demonstrated in patients with major depression when compared with controls (28,(31)(32)(33)(34). The atrophy demonstrated in patients with MDD by using MRI is more pronounced in, but not restricted to, the prefrontal lobe (28,33). Earlier findings from our laboratory indicate that an increase in cerebrospinal fluid volume (serving as an indirect measure of atrophy) and overall medical burden, increases the odds ratio for the prevalence of existing MDD (28,57).…”
Section: Discussionmentioning
confidence: 72%
“…A combination of mechanisms may therefore be involved, with clinical depression representing the end point of the various neurobiological aberrations. Smaller brain volumes and larger high intensity lesion volumes have been demonstrated in patients with major depression when compared with controls (28,(31)(32)(33)(34). The atrophy demonstrated in patients with MDD by using MRI is more pronounced in, but not restricted to, the prefrontal lobe (28,33).…”
Section: Discussionmentioning
confidence: 99%
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“…Substantial reductions in the volume of gray matter are found in the temporal lobe as a whole (Altshuler et al, 1991;Hauser et al, 1989), in the subgenual cortex (Drevets et al, 1997), and in the amygdala (Pearlson et al, 1997;Sheline et al, 1998) in MDD and bipolar disorder (BPD). Moderate reductions in the total volume of the frontal white and gray matter have been described in MDD (Coffey et al, 1993). Moreover, shrinkage in the volume of the hippocampus has been observed in both alcoholism (Agartz et al, 1999;Sullivan et al, 1995) and MDD (Bremner et al, 2000;Sheline et al, 1996).…”
Section: Neuroimaging Studiesmentioning
confidence: 99%