Cognitive impairment in cerebellar lesions: a logit model based on neuropsychological testing

Bolceková, Eva; Mojzes, Matej; Tran, Quang Van; Kukal, Jaromír; Ostrý, Svatopluk; Kulišťák, Petr; Rusina, Robert

doi:10.1186/s40673-017-0071-9

Cited by 26 publications

(24 citation statements)

References 45 publications

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“…Consistent with their study, our finding of positive correlation with ALFF in the SFG and putamen demonstrated that the spontaneous activity within these regions decreased as the executive dysfunction progresses. Additionally, the involvement of cerebellum in the executive functions has been well established 50 – 52 , and the interconnection between the cerebellum and the prefrontal cortex plays an important role in the pathogenesis of executive function impairment 50 , 53 . In the present study, the negative correlation between the ALFF in the Crus I of cerebellum and Executive Function sub-score might be a reflection of the cerebellar compensatory effect to maintain the executive function in patients with FOG.…”

Section: Discussionmentioning

confidence: 99%

Altered resting-state brain activity in Parkinson’s disease patients with freezing of gait

Mei

Liang

et al. 2017

Sci Rep

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Freezing of gait (FOG) is a common and debilitating symptom in Parkinson’s disease (PD). The current study investigated alterations of resting-state spontaneous brain activity in PD patients with FOG. A total of 29 patients with FOG, 28 patients without FOG and 31 controls were included. All subjects underwent resting-state functional MRI, and the amplitude of low-frequency fluctuation (ALFF) was calculated to measure the spontaneous brain activity. Between-group differences and correlations with FOG severity (both subjective and objective measures) were analyzed. Compared to those without FOG, patients with FOG showed increased ALFF in right anterior cingulate cortex (ACC) and left inferior parietal lobule (IPL), as well as decreased ALFF in right superior frontal gyrus (SFG), bilateral cerebellum and left thalamus. Correlation analyses demonstrated that ALFF within the right SFG, right ACC and bilateral pallidum were positively correlated with FOG; while ALFF within the thalamus, putamen, cerebellum and sensorimotor regions were negatively correlated. Our results indicate that FOG is associated with dysfunction within frontal-parietal regions, along with increased inhibitory outputs from basal ganglia. Additionally, altered activity of cerebellum implicates its role in the pathophysiology of FOG. These findings provide further insight into the underlying neural mechanisms of FOG in PD patients.

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Section: Discussionmentioning

confidence: 99%

Altered resting-state brain activity in Parkinson’s disease patients with freezing of gait

Mei

Liang

et al. 2017

Sci Rep

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“…2 Verbal Fluency test is designed to assess the component process of executive functioning. The examinee is asked to say words that begin with a specific letter (phonemic fluency) or words that belong to a designated semantic category (semantic fluency) within time-constrained (3,(22)(23)(24).…”

Section: Resultsmentioning

confidence: 99%

“…The test is meant to assess visual scanning, number sequencing, and number-letter switching. TMT A and TMT B are to assess the speed of processing, while TMT B minus TMT A is to assess the executive functioning (3,22,23,25,26).…”

Section: Resultsmentioning

confidence: 99%

“…This bedside tool aimed to facilitate physicians in diagnosing the syndrome and to lead to uniformity across studies. Second, the current CCAS literature consists of only small series of patients that are frequently biased by patient selection rather than consecutive inclusion (1,(3)(4)(5)(6)(7)(8)(9)(10)(11)(12). Some studies include children, thereby not differentiating between the CCAS and postoperative paediatric Cerebellar Mutism Syndrome (ppCMS) (11,12).…”

Section: Introductionmentioning

confidence: 99%

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The Cerebellar Cognitive Affective Syndrome—a Meta-analysis

et al. 2019

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The cerebellar cognitive affective syndrome (CCAS) was first described by Schmahmann and Sherman in 1998. Despite their clear depiction of the syndrome, it is our experience that the CCAS has not yet found solid ground as a disease entity in routine clinical practice. This made us question the dimension of the CCAS in cerebellar patients. We performed a systematic review of the literature according to the PRISMA guidelines, in order to answer the question whether patients with acquired isolated cerebellar lesions perform significantly worse on neuropsychological testing compared to healthy controls. Studies were selected based on the predefined eligibility criteria and quality assessment. The systematic search resulted in ten studies, mainly observational cohorts consecutively including adult patients with isolated cerebellar lesions. Patients were compared to healthy controls, and neuropsychological investigation was done within one year of diagnosis. Meta-analysis of the twelve tests that were done in two or more studies showed that cerebellar patients perform significantly worse on Phonemic Fluency, Semantic Fluency, Stroop Test (naming, reading and interference), Block Design test and WMS-R visual memory. Cerebellar patients have significant and relevant deficits in the visuospatial, language and executive function domain. This meta-analysis therefore emphasizes the importance of the cerebellar cognitive affective syndrome as described by Schmahmann and Sherman.

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“…Clinically, uncharacteristic emotional features resulting from cerebellar damage have been noted such as disinhibited behavioral responses and impulsivity in a patient with a right cerebellar infarction [ 9 ], stubbornness, thought rigidity, and inappropriate behavior (e.g., indecent humor) in patients with right-sided cerebellar lesions [ 7 ], and blunted emotional affect, social withdrawal, and low motivation in patients with left-sided cerebellar lesions [ 7 ]. In an extension of these clinical data, one study inferred that patients with cerebellar lesions may have a poor comprehension of their own emotional state because they did not report mood symptoms that they were observed to exhibit [ 10 ]. Some data suggest that cerebellar damage occurring earlier in life may result in more readily apparent emotion deficits by impacting normative growth processes such as social development and communication [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

The role of cerebellar impairment in emotion processing: a case study

Gold

Toomey

2018

cerebellum ataxias

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BackgroundThough the cerebellum’s role in visuospatial and fine motor functioning has been well-established over the last several years, the role of the cerebellum in emotion has more recently been a focus of scientific inquiry. Cerebellar impairment has been associated with deficits in emotional processing and is linked to a wide range of clinical behaviors including social withdrawal, blunted emotional expression, and impulsivity. In addition, cerebellar impairments have been associated with the onset of psychiatric disorders including major depressive disorder and, more recently, obsessive-compulsive disorder.Case presentationWe describe a 32-year-old patient who presented to our clinic for a neuropsychological evaluation with a childhood history of a cerebellar brain tumor and detail-oriented, perfectionistic tendencies. Neuropsychological assessment data revealed impairments in visuospatial processing and in fine motor skills, likely stemming from the cerebellar tumor. Clinical assessment led to a diagnosis of obsessive-compulsive personality disorder and also suggested impairments in socio-emotional processing.ConclusionsOur findings lend support to recent data which has suggested the impact of cerebellar impairment on emotional processing and related domains. Unlike many previous studies, however, our report focuses on an individual who, despite having marked impairments in certain domains, demonstrates a high level of functioning. We believe that this report holds important clinical relevance for proper diagnosis of cerebellar-related impairment and for the necessity of early intervention.

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Cognitive impairment in cerebellar lesions: a logit model based on neuropsychological testing

Cited by 26 publications

References 45 publications

Altered resting-state brain activity in Parkinson’s disease patients with freezing of gait

Altered resting-state brain activity in Parkinson’s disease patients with freezing of gait

The Cerebellar Cognitive Affective Syndrome—a Meta-analysis

The role of cerebellar impairment in emotion processing: a case study

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