Cognitive impairments and depression in Parkinson's disease: a follow up study.

Starkstein, Sergio E.; Bolduc, Paula L.; Mayberg, Helen S.; Preziosi, Thomas J.; Robinson, Robert G.

doi:10.1136/jnnp.53.7.597

Cited by 122 publications

(77 citation statements)

References 27 publications

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“…Furthermore, the presence of severe cognitive deterioration seems to be accompanied by a decreased life expectancy. This finding is in agreement with other recent studies reporting that dementia in parkinsonian patients alters the prognosis and reduces survival [31][32][33][34], The nat ural history of parkinsonian dementia therefore does not seem to be any different than the history of other forms of progressively disabling degenerative dementia [35].…”

Section: Discussionsupporting

confidence: 82%

Neuropsychological Follow-Up of Parkinsonian Patients with and without Cognitive Impairment

Piccirilli

D’Alessandro²,

Finali³

et al. 1994

Dement Geriatr Cogn Disord

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In order to evaluate possible progression in the severity of their cognitive impairment, 34 parkinsonians with intellectual impairment were followed longitudinally for 7 years. Each patient was matched for age, sex, severity and duration of illness, and pharmacological treatment, with a parkinsonian patient without cognitive impairment. Results suggest that cognitive deficits are not static but rather there is a progression in the severity. Furthermore, patients suffering from severe dementia are more likely to die during the follow-up period. The prognosis of Parkinson''s disease seems to be changed substantially by the occurrence of dementia. The natural history of parkinsonian dementia does not seem to differ from the history of other forms of dementia with a progressively disabling course leading to a complete loss of autonomy.

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Section: Discussionsupporting

confidence: 82%

Neuropsychological Follow-Up of Parkinsonian Patients with and without Cognitive Impairment

Piccirilli

D’Alessandro²,

Finali³

et al. 1994

Dement Geriatr Cogn Disord

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“…A relationship between motor severity [25][26][27][28][29] and depression [26,30,31] has been demonstrated in other studies of dementia in PD. Depression is common in PD [32,33] and it is possible that depression may coexist with dementia rather than exert a negative effect upon it.…”

Section: Discussionmentioning

confidence: 93%

The detection of dementia and cognitive impairment in a community population of elderly people with Parkinson's disease by use of the CAMCOG neuropsychological test

Hobson¹

1999

Age and Ageing

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Aim: to assess cognitive function in elderly subjects with clinically probable Parkinson's disease (PD). Methods: a community sample of 126 patients with probable PD completed the CAMCOG, which is the cognitive section of the Cambridge Examination for Mental Disorders, and the Mini-Mental State Examination (MMSE). The performance of the CAMCOG and the MMSE in detecting dementia in this subject group was compared with the results of applying the DSM-IV criteria for dementia to this population. Results: A total of 44% of the group met DSM-IV criteria for dementia, which is higher than most previous prevalence figures for dementia in PD. The CAMCOG was more sensitive than the MMSE in detecting cognitive impairment and more specific than the MMSE in detecting dementia as defined by DSM-IV criteria. Poorer performance on the CAMCOG was related to gender, social class and age (P < 0.05). Among subjects with PD, those with dementia, as defined by DSM-IV criteria, were significantly older, had greater depressive symptomatology and had greater motor deficits. A greater proportion of the group with dementia were living in residential care (P < 0.05). Conclusion:The CAMCOG appears to be a useful screening instrument for dementia and cognitive impairment in PD. Furthermore, it may prove helpful in detecting those with PD who may be at risk of developing dementia and in longitudinal studies of cognitive function in PD.

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“…Conversely a previous review yielded only two studies with conflicting results. The early one did not find an association between depression and survival in PD 12 , whereas Hughes et al 13 , reported that depressed PD patients presented a 1.64 (CI 1.26-2.99) risk of death as compared to controls. In order to provide more information on this issue, the aim of this study is to evaluate the survival rate in a cohort of PD patients with and without depression.…”

Section: Introductionmentioning

confidence: 94%

The impact of depression on survival of Parkinson's disease patients: a five-year study

Silberman

Rodrigues

Engelhardt

et al. 2013

J. bras. psiquiatr.

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Objective: The aim of this study is to evaluate the survival rate in a cohort of Parkinson's disease patients with and without depression. Methods: A total of 53 Parkinson's disease subjects were followed up from 2003-2008 and 21 were diagnosed as depressed. Mean time of follow up was 3.8 (SD 95% = 1.5) years for all the sample and there was no significant difference in mean time of follow up between depressed and nondepressed Parkinson's disease patients. Survival curves rates were fitted using the Kaplan-Meier method. In order to compare survival probabilities according to the selected covariables the Log-Rank test was used. Multivariate analysis with Cox regression was performed aiming at estimating the effect of predictive covariables on the survival. results: The cumulative global survival of this sample was 83% with nine deaths at the end of the study -five in the depressed and four in the nondepressed group, and 55.6% died in the first year of observation, and none died at the fourth and fifth year of follow up. conclusion: Our finding point toward incremental death risk in depressed Parkinson's disease patients. reSUMOObjetivo: O objetivo deste estudo é avaliar a taxa de mortalidade em uma coorte de parkinsonianos com e sem depressão. Métodos: O total de 53 pacientes com doença de Parkinson foi acompanhado de 2003 a 2008, e 21 deles foram avaliados com depressão. O tempo médio de doença foi de 3,8 (DP 95% = 1,5) anos para toda a amostra e não houve diferença significativa entre os parkinsonianos, com e sem depressão, acompanhados durante esse período. Curvas de sobrevida foram obtidas utilizando-se o método de Kaplan-Meier. A fim de comparar as probabilidades de sobrevivência de acordo com as covariáveis selecionadas, o teste Log-Rank foi usado. A análise multivariada com regressão de Cox foi realizada com o objetivo de estimar o efeito de covariáveis preditivas sobre a sobrevivência. resultados: A sobrevivência global acumulada dessa amostra foi de 83%, com nove mortes no final do estudo -cinco no grupo com depressão e quatro no grupo sem depressão. Além disso, 55,6% morreram durante o primeiro ano de observação, e nenhum morreu no quarto e quinto ano de acompanhamento. conclusão: Nossos achados indicam um incremento no risco de morte em pacientes com doença de Parkinson e depressão.

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Cognitive impairments and depression in Parkinson's disease: a follow up study.

Cited by 122 publications

References 27 publications

Neuropsychological Follow-Up of Parkinsonian Patients with and without Cognitive Impairment

Neuropsychological Follow-Up of Parkinsonian Patients with and without Cognitive Impairment

The detection of dementia and cognitive impairment in a community population of elderly people with Parkinson's disease by use of the CAMCOG neuropsychological test

The impact of depression on survival of Parkinson's disease patients: a five-year study

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