Cognitive impairments associated with morphological changes in cortical and subcortical structures in multiple system atrophy of the cerebellar type

Lee, M. J.; Shin, Jeong Hee; Seoung, J.-K.; Lee, Junhee; Yoon, Uicheul; Oh, Jee-Young; Jung, Dae Soo; Kim, E.-J.

doi:10.1111/ene.12796

Cited by 36 publications

(29 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Recently, neuropathological studies reported an association of neuronal cytoplasmatic inclusions in neocortex or limbic regions and cognitive impairment in MSA . Additionally, imaging data also suggest that beside atrophy of subcortical regions, thinning of neocortices may contribute to cognitive impairment . In this study, MSA‐C patients showed to be more frequently impaired in a screening of executive function, possibly resulting from disruption of cerebrocerebellar circuits.…”

Section: Discussionmentioning

confidence: 47%

“…9,20,21 Additionally, imaging data also suggest that beside atrophy of subcortical regions, thinning of neocortices may contribute to cognitive impairment. [61][62][63] In this study, MSA-C patients showed to be more frequently impaired in a screening of executive function, possibly resulting from disruption of cerebrocerebellar circuits. This phenomenon has also been observed in other cerebellar disorders, as the cerebellum functionally modulates higher cognition.…”

Section: Discussionmentioning

confidence: 52%

See 1 more Smart Citation

Cognition in multiple system atrophy: a single‐center cohort study

Eschlböck

Delazer

Krismer

et al. 2020

Ann Clin Transl Neurol

View full text Add to dashboard Cite

Objective Cognitive impairment in multiple system atrophy (MSA) is common, but remain poorly characterized. We evaluated cognitive and behavioral features in MSA patients and assessed between‐group differences for MSA subtypes and the effect of orthostatic hypotension (OH) on cognition. Methods This retrospective study included 54 patients with clinical diagnosis of possible and probable MSA referred to the Department of Neurology at Medical University of Innsbruck between 2000 and 2018. Neurological work‐up included comprehensive neuropsychological testing including Consortium to Establish a Registry for Alzheimer's Disease (CERAD‐plus) test battery, Frontal Assessment Battery (FAB), digit span test (DST), clock drawing task (CLOX1), and Hospital Anxiety and Depression Scale (HADS‐D). Results The mean MMSE score was 27.6 points. Overall, slight to moderate cognitive impairment was noted in up to 40% of patients, with predominant impairment of executive function and verbal memory. Patients with the cerebellar variant performed significantly worse than patients with the parkinsonian type (P < 0.05) in a screening of executive functions (FAB) and in phonemic verbal fluency. Depression and anxiety scores were elevated in 28% and 22% of MSA patients, respectively. Cognitive profile, depression, and anxiety levels were comparable between patients with and without OH. Interpretation Cognitive deficits are relatively frequent in MSA and primarily affect executive functions and verbal memory. Future comparative studies including Parkinson dementia, Lewy body disease, and MSA cases with and without OH are required to elucidate disease‐specific cognitive profiles in these synucleinopathies and to examine the influence of cardiovascular autonomic dysfunction on cognitive function in MSA.

show abstract

Section: Discussionmentioning

confidence: 47%

Section: Discussionmentioning

confidence: 52%

Cognition in multiple system atrophy: a single‐center cohort study

Eschlböck

Delazer

Krismer

et al. 2020

Ann Clin Transl Neurol

View full text Add to dashboard Cite

show abstract

“…Indeed, it is difficult to compare VBM performed with statistical parametric mapping with cortical thickness measures, because these 2 methods are based on a completely different statistical background. Cortical thickness analysis in MSA‐C showed cortical thinning in the frontal, temporal, parietal, parahippocampal, and lingual cortices . Intriguingly, cortical thinning in the left prefrontal cortex and the right parahippocampal cortex correlated with the severity of dysarthria.…”

Section: Mri Findings Of Msamentioning

confidence: 94%

“…Cortical thickness analysis in MSA-C showed cortical thinning in the frontal, temporal, parietal, parahippocampal, and lingual cortices. 58,59 Intriguingly, cortical thinning in the left prefrontal cortex and the right parahippocampal cortex correlated with the severity of dysarthria. In MSA-P, cortical thinning was reported in the frontal motor cortex and the premotor cortex.…”

Section: Automated Volumetric and Cortical Thickness Analysesmentioning

confidence: 98%

Role of Magnetic Resonance Imaging in the Diagnosis of Multiple System Atrophy

Kim

Jeon

Fung

2016

Movement Disord Clin Pract

View full text Add to dashboard Cite

Background: Multiple system atrophy (MSA) is a rapidly progressing neurodegenerative disorder without effective disease-modifying therapies. Because of a lack of reliable diagnostic biomarkers, there has been increasing interest in using magnetic resonance imaging (MRI) to improve the diagnostic accuracy of MSA.Methods: This review summarizes recent literatures on the role of MRI in the diagnosis of MSA. Results: Several MRI abnormalities on conventional MRI already are included in the current diagnostic criteria for MSA. Other features on conventional MRI are also used to make a diagnosis of MSA or to rule out alternative diagnoses. On the other hand, some of the MRI findings that were previously considered suggestive of a diagnosis of MSA are now being challenged, because it turned out that they were not as specific to MSA as previously thought. More advanced MRI modalities, including susceptibility-weighted imaging, diffusion-weighted imaging, diffusion tensor imaging, voxel-based morphometry, and cortical thickness analysis, are now used to study the changes in the brains of patients with MSA. Furthermore, studies have produced promising results demonstrating the use of MRI as a tool for monitoring and assessing disease progression in MSA. Conclusions: MRI is useful and indispensable in the diagnosis of MSA and also possibly for monitoring disease progression. In this regard, well-designed, long-term, prospective studies on large numbers of patients are needed.

show abstract

“…Parkinson disease (PD) in its early years can be well managed with symptomatic dopaminergic therapy , whilst other movement disorders are less satisfactorily treated . The development of motor complications is a significant limitation to the long term use of levodopa.…”

mentioning

confidence: 99%