Cognitive improvement in first-episode schizophrenia and healthy controls: A 6-year multi-assessment follow-up study

Fu, Susie; Czajkowski, Nikolai Olavi; Torgalsbøen, Anne‐Kari

doi:10.1016/j.psychres.2018.06.016

Cited by 13 publications

(7 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…On the other hand, in the case of MDD, relative to HC, WM performance has sometimes been reported to be impaired (Chen et al, 2018; Christopher & MacDonald, 2005; Egeland et al, 2003; Liu et al, 2019; Noort et al, 2016; Pu et al, 2011; Pu et al, 2018; Schwert, Stohrer, Aschenbrenner, Weisbrod, & Schröder, 2019) or sometimes not (Channon, Baker, & Robertson, 1993; Murphy et al, 2019; Trapp et al, 2017; Yuksel et al, 2018). Furthermore, WM deficits have been reported to increase over time in SZ (Fu, Czajkowski, & Torgalsboen, 2018; Jimenez‐Lopez et al, 2019; Park, Püschel, Sauter, Rentsch, & Hell, 1999; Strugstad, Lau, & Glenne Oie, 2018), but not in MDD (Nuninga et al, 2018; Sankar, Adams, Costafreda, Marangell, & Fu, 2017; Vasavada et al, 2017; Zuidersma, Comijs, Naarding, & Oude Voshaar, 2016). WM is also more impaired in SZ than in MDD (Egeland et al, 2003; Mahmood, Burton, Vella, & Twamley, 2018; Yamashita et al, 2018), and measurement of WM deficit may represent a promising endophenotype for studying the disorders (Glahn et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Shared and distinct brain fMRI response during performance of working memory tasks in adult patients with schizophrenia and major depressive disorder

Wang

Cheng

Roberts

et al. 2021

Human Brain Mapping

View full text Add to dashboard Cite

Working memory (WM) impairments are common features of psychiatric disorders. A systematic meta‐analysis was performed to determine common and disorder‐specific brain fMRI response during performance of WM tasks in patients with SZ and patients with MDD relative to healthy controls (HC). Thirty‐four published fMRI studies of WM in patients with SZ and 18 published fMRI studies of WM in patients with MDD, including relevant HC, were included in the meta‐analysis. In both SZ and MDD there was common stronger fMRI response in right medial prefrontal cortex (MPFC) and bilateral anterior cingulate cortex (ACC), which are part of the default mode network (DMN). The effects were of greater magnitude in SZ than MDD, especially in prefrontal‐temporal‐cingulate‐striatal‐cerebellar regions. In addition, a disorder‐specific weaker fMRI response was observed in right middle frontal gyrus (MFG) in MDD, relative to HC. For both SZ and MDD a significant correlation was observed between the severity of clinical symptoms and lateralized fMRI response relative to HC. These findings indicate that there may be common and distinct anomalies in brain function underlying deficits in WM in SZ and MDD, which may serve as a potential functional neuroimaging‐based diagnostic biomarker with value in supporting clinical diagnosis, measuring illness severity and assessing the efficacy of treatments for SZ and MDD at the brain level.

show abstract

Section: Introductionmentioning

confidence: 99%

Shared and distinct brain fMRI response during performance of working memory tasks in adult patients with schizophrenia and major depressive disorder

Wang

Cheng

Roberts

et al. 2021

Human Brain Mapping

View full text Add to dashboard Cite

show abstract

“…A recent 24-month longitudinal study of young people with early onset schizophrenia also found this group to have a similar cognitive course to healthy controls, albeit functioning at an overall lower level (31). Improvement has also been seen in first episode schizophrenia, even with test batteries designed to withstand learning effects (32). The only study to date to retest UHR subjects after 10 years found no decline in cognition except in tests of immediate verbal learning and memory (33).…”

Section: Introductionmentioning

confidence: 99%

Cognitive Profile in Ultra High Risk for Psychosis and Schizophrenia: A Comparison Using Coordinated Norms

et al. 2019

View full text Add to dashboard Cite

Background: Cognitive impairment is not only a core aspect of schizophrenia but also commonly observed in help-seeking youth at ultra high risk for psychosis (UHR), with potential implications for prognosis and individualized treatment. However, there is no consensus on the cognitive profile in the UHR state, partly due to lack of valid comparisons of performance in established schizophrenia and UHR. Objectives: To compare the cognitive functioning and profile of UHR subjects to a sample with schizophrenia, they were split into two groups based on duration of illness. Comparisons were made using coordinated norms based on healthy controls reflecting the younger UHR age spectrum. Methods: Participants for UHR (n = 51) and schizophrenia groups (n = 19 and n = 22) were included from the Prevention of Psychosis and Bergen Psychosis 2 projects. All subjects completed a comprehensive neurocognitive test battery aiming to measure speed of processing, working memory, verbal learning, reasoning, and problem solving, as well as visual problem solving. Cognitive functioning was compared between groups based on coordinated norms using z-scores derived by regression modeling from an age-matched healthy control group (n = 61). Results: UHR subjects showed significantly impaired speed of processing (p < 0.001) working memory (p = 0.042) and verbal learning, reasoning, and problem solving (p = 0.007) as compared to the control group. Visual problem-solving skills appeared unimpaired. UHR subjects significantly outperformed the schizophrenia group with duration of illness >3 years for speed of processing and working memory (both p < 0.001). There were no significant differences in performance between the UHR group and the group with duration of schizophrenia <3 years. Conclusion: Cognitive performance is impaired in UHR subjects as compared to healthy controls and should thus be monitored when a person is deemed at high risk of psychotic illness. Spatial skills, as measured by tests using physical objects, appear less affected than other domains. The pattern of impairment is similar to that of a group with recent onset schizophrenia but is less severe than in a group with duration of illness <3 years.

show abstract

“…significant cognitive deficits across multiple cognitive domains assessed with the MCCB [5][6][7][8][9].…”

mentioning

confidence: 99%

Relationships between abnormal neural activities and cognitive impairments in patients with drug-naive first-episode schizophrenia

et al. 2020

View full text Add to dashboard Cite

Background: Prior resting state functional Magnetic Resonance Imaging studies (rs-fMRI) via the regional homogeneity (ReHo) method have demonstrated inconsistent and conflicting results because of several confounding factors, such as small sample size, medicinal influence, and illness duration. Relationships between ReHo measures and cognitive impairments in patients with drug-naive First-Episode Schizophrenia (dn-FES) are rarely reported. This study was conducted to explore the correlations between ReHo measures and cognitive deficits and clinical symptoms in patients with dn-FES. Methods: A total of 69 patients with dn-FES and 74 healthy controls were recruited. MATRICS Consensus Cognitive Battery (MCCB), Wechsler Adult Intelligence Scale (WAIS), and Positive And Negative Syndrome Scale (PANSS) were used to assess cognitive function, Intelligence Quotient (IQ), and clinical symptoms, respectively. The correlations between ReHo maps and cognitive deficits and the severity of symptoms were examined using strict correlation analysis. Results: ReHo values in right Middle Frontal Gyrus (MFG) and Superior Frontal Gyrus (SFG) increased in dn-FES group, whereas ReHo values in right cuneus decreased. Correlation analysis showed that the ReHo values in right MFG positively correlated with attention/vigilance impairments, social cognition deficits, and the severity of clinical manifestations. Conclusions: These findings suggested that abnormal spontaneous activities in right MFG reflect illness severity and cognitive deficits, which also serve as a basis for establishing objective diagnostic markers and might be a clinical intervention target for treating patients with schizophrenia.

show abstract

Cognitive improvement in first-episode schizophrenia and healthy controls: A 6-year multi-assessment follow-up study

Cited by 13 publications

References 48 publications

Shared and distinct brain fMRI response during performance of working memory tasks in adult patients with schizophrenia and major depressive disorder

Shared and distinct brain fMRI response during performance of working memory tasks in adult patients with schizophrenia and major depressive disorder

Cognitive Profile in Ultra High Risk for Psychosis and Schizophrenia: A Comparison Using Coordinated Norms

Relationships between abnormal neural activities and cognitive impairments in patients with drug-naive first-episode schizophrenia

Contact Info

Product

Resources

About