Cognitive mapping deficits in schizophrenia: Evidence from clinical correlates of visuospatial transformations

Agarwal, Sri Mahavir; Danivas, Vijay; Amaresha, Anekal C.; Shivakumar, Venkataram; Kalmady, Sunil V.; Bose, Anushree; Narayanaswamy, Janardhanan C.; Venkatasubramanian, Ganesan

doi:10.1016/j.psychres.2015.05.096

Cited by 13 publications

(9 citation statements)

References 43 publications

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“…We found altered nodal properties in regions involving in perceptual (i.e., precentral gyrus, inferior occipital gyrus, superior temporal gyrus, middle temporal gyrus, and inferior temporal gyrus), affective (i.e., insula, temporal pole, and orbitofrontal cortex), lingual and spatial processing (i.e., angular gyrus, supramarginal gyrus, and superior parietal lobule). These functional impairments have been frequently reported in schizophrenia (Bellani et al, 2009 ; De Sanctis et al, 2013 ; Postmes et al, 2014 ; Agarwal et al, 2015 ; Strauss et al, 2015 ). These findings are consistent with the concept that schizophrenia is linked with disturbance of multiple systems (Karbasforoushan and Woodward, 2012 ).…”

Section: Discussionmentioning

confidence: 72%

Altered Cerebral Blood Flow Covariance Network in Schizophrenia

Liu

Zhuo

2016

Front. Neurosci.

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Many studies have shown abnormal cerebral blood flow (CBF) in schizophrenia; however, it remains unclear how topological properties of CBF network are altered in this disorder. Here, arterial spin labeling (ASL) MRI was employed to measure resting-state CBF in 96 schizophrenia patients and 91 healthy controls. CBF covariance network of each group was constructed by calculating across-subject CBF covariance between 90 brain regions. Graph theory was used to compare intergroup differences in global and nodal topological measures of the network. Both schizophrenia patients and healthy controls had small-world topology in CBF covariance networks, implying an optimal balance between functional segregation and integration. Compared with healthy controls, schizophrenia patients showed reduced small-worldness, normalized clustering coefficient and local efficiency of the network, suggesting a shift toward randomized network topology in schizophrenia. Furthermore, schizophrenia patients exhibited altered nodal centrality in the perceptual-, affective-, language-, and spatial-related regions, indicating functional disturbance of these systems in schizophrenia. This study demonstrated for the first time that schizophrenia patients have disrupted topological properties in CBF covariance network, which provides a new perspective (efficiency of blood flow distribution between brain regions) for understanding neural mechanisms of schizophrenia.

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Section: Discussionmentioning

confidence: 72%

Altered Cerebral Blood Flow Covariance Network in Schizophrenia

Liu

Zhuo

2016

Front. Neurosci.

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“…The tasks used in this study explored spatial cognition of perspective change which has associations with multiple interrelated aspects of interest in neuroscience and psychiatry like theory of mind and empathy, 14) schizotypy, 14 , 15) and schizophrenia psychopathology. 6 , 16) This pilot study is the first to evaluate the difference between OLMT and VPRT in an fMRI context, and adds to the findings of previous studies, 3) wherein OLMT was compared with TT, but a comparison between OLMT and VPRT was not made. In a recent metanalysis of fMRI studies examining perspective taking left TPJ was found to involved in the processing of alternative perspectives, that is important in both visual perspective taking, as well was false belief reasoning.…”

Section: Discussionmentioning

confidence: 85%

“…Hence, understanding this deficit and its neural correlates further would help further our understanding of cognitive deficits in schizophrenia. 6) …”

Section: Introductionmentioning

confidence: 99%

Neural Correlates of a Perspective-taking Task Using in a Realistic Three-dimmensional Environment Based Task: A Pilot Functional Magnetic Resonance Imaging Study

Agarwal

Shivakumar

Kalmady

et al. 2017

Clin Psychopharmacol Neurosci

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ObjectivePerspective-taking ability is an essential spatial faculty that is of much interest in both health and neuropsychiatric disorders. There is limited data on the neural correlates of perspective taking in the context of a realistic three-dimensional environment. We report the results of a pilot study exploring the same in eight healthy volunteers.MethodsSubjects underwent two runs of an experiment in a 3 Tesla magnetic resonance imaging (MRI) involving alternate blocks of a first-person perspective based allocentric object location memory task (OLMT), a third-person perspective based egocentric visual perspective taking task (VPRT), and a table task (TT) that served as a control. Difference in blood oxygen level dependant response during task performance was analyzed using Statistical Parametric Mapping software, version 12. Activations were considered significant if they survived family-wise error correction at the cluster level using a height threshold of p<0.001, uncorrected at the voxel level.ResultsA significant difference in accuracy and reaction time based on task type was found. Subjects had significantly lower accuracy in VPRT compared to TT. Accuracy in the two active tasks was not significantly different. Subjects took significantly longer in the VPRT in comparison to TT. Reaction time in the two active tasks was not significantly different. Functional MRI revealed significantly higher activation in the bilateral visual cortex and left temporoparietal junction (TPJ) in VPRT compared to OLMT.ConclusionThe results underscore the importance of TPJ in egocentric manipulation in healthy controls in the context of reality-based spatial tasks.

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“…Neurocognitive assessments for arithmetic skills (Table 2) were undertaken using a special battery (consisting of 15 different tests adapted from numerical activities of daily living,7) and proposed extension of EC301 battery by Ardila and Rosselli,8) applied in a standard method on all the assessments) and spatial orientation by computerized mental rotation tasks9) were tested before and after 10 days of tDCS and repeated during follow-up at 1st and 3rd month. Fluency for numbers (errors and time taken in digit forward and backward count) and numerosity (errors in estimation in a brief duration) showed significant improvement; there were concurrent improvement in constructional (clock and vase drawing) and gestalt perception (ordering and reading spaced words) abilities as well.…”

Section: Casementioning

confidence: 99%

A Functional Domain Based Approach in Neurocognitive Rehabilitation with Transcranial Direct Current Stimulation: A Case Report

Sreeraj

Shivakumar

Bose

et al. 2019

Clin Psychopharmacol Neurosci

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Transcranial direct current stimulation (tDCS) is a novel brain stimulation technique which has kindled hope in alleviating motor, language as well as cognitive deficits in neuronal injury. Current case report describes application of tDCS in two phases using two different protocols in a patient with hypoxic injury. In the first phase anodal stimulation of dorsolateral prefrontal cortex improved the language fluency. Subsequently, after 6 months second phase application of anodal stimulation over posterior parietal region targeted arithmetic and working memory deficits. Individualising the treatment protocols of brain stimulation, based on the lesion and the functional deficits, for neuro-rehabilitation is emphasised.

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Cognitive mapping deficits in schizophrenia: Evidence from clinical correlates of visuospatial transformations

Cited by 13 publications

References 43 publications

Altered Cerebral Blood Flow Covariance Network in Schizophrenia

Altered Cerebral Blood Flow Covariance Network in Schizophrenia

Neural Correlates of a Perspective-taking Task Using in a Realistic Three-dimmensional Environment Based Task: A Pilot Functional Magnetic Resonance Imaging Study

A Functional Domain Based Approach in Neurocognitive Rehabilitation with Transcranial Direct Current Stimulation: A Case Report

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