Cognitive-Motor Interference in Neurodegenerative Disease: A Narrative Review and Implications for Clinical Management

McIsaac, Tara L.; Fritz, Nora; Quinn, Lori; Muratori, Lisa M.

doi:10.3389/fpsyg.2018.02061

Cited by 41 publications

(26 citation statements)

References 77 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The dual-task paradigm, i.e., the simultaneous performance of motor and cognitive tasks, can assess the extent that cognitive tasks interfere with automatic motor activity, such as balance and gait, i.e., cognitive-motor interference (CMI) (8,9). One way to test CMI mechanisms consists of the simultaneous execution of cognitive tests during a postural stability assessment (8).…”

Section: Introductionmentioning

confidence: 99%

Attention-Demanding Cognitive Tasks Worsen Postural Control in Patients With Cervical Dystonia: A Case-Control Study

et al. 2021

View full text Add to dashboard Cite

Background: Patients with cervical dystonia (CD) show impaired postural control, balance, and gait, likely due to abnormal head postures and sensorimotor disturbances. However, until now no study has investigated whether attention-demanding activity worsens postural control and balance in CD patients.Objective: To investigate whether patients with CD show cognitive-motor interference (CMI), a specific kind of dual-task interference that occurs during the simultaneous execution of a cognitive and motor task. This information may be useful to determine whether performing activities of daily living worsens postural control and balance in CD patients.Methods: We performed a pilot case-control study. Twenty-two patients affected by CD and 19 healthy controls were enrolled in order to test CMI. Each subject was evaluated during the execution of a cognitive task while postural stability was assessed through a stabilometric platform.Results: CD patients showed impaired postural control compared to healthy controls, with instability increasing with increasing cognitive task complexity. No relationships were found between stabilometric parameters and clinical characteristics of CD.Conclusions: Our hypothesis is that CMI in CD patients derives from deranged network connectivity when activated simultaneously during the performance of two tasks that interfere with each other and “compete” for the same resources within the cognitive system.

show abstract

Section: Introductionmentioning

confidence: 99%

Attention-Demanding Cognitive Tasks Worsen Postural Control in Patients With Cervical Dystonia: A Case-Control Study

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Additionally, dual-task walking requires increased cognitive and motor demands [ 9 ]. Due to the high prevalence of cognitive (65%) and motor deficits (85%) in MS [ 10 ], it is not surprising that impairments in dual-task walking are seen in individuals with MS [ 11 – 14 ] and have been related to cognition, fall risk [ 15 ], dynamic balance control [ 7 ], and connectivity in the supplemental motor area [ 16 ]. Moreover, dual-task performance is modulated by neurobiological systems [ 17 , 18 ] affected in MS, like the dopaminergic system [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

Backward Walking and Dual-Task Assessment Improve Identification of Gait Impairments and Fall Risk in Individuals with MS

Edwards

Kegelmeyer

Kloos

et al. 2020

Multiple Sclerosis International

Self Cite

View full text Add to dashboard Cite

Background. Individuals with multiple sclerosis (MS) experience deficits in motor and cognitive domains, resulting in impairment in dual-task walking ability. The goal of this study was to compare performance of forward walking and backward walking in single- and dual-task conditions in persons with MS to age- and sex-matched healthy controls. We also examined relationships between forward and backward walking to cognitive function, balance, and retrospective fall reports. Methods. All measures were collected in a single session. A 2×2×2 mixed model ANOVA was used to compare differences in forward and backward walking in single- and dual-task conditions between MS and healthy controls. Spearman correlations were used to examine relationships between gait and cognitive function, falls, and balance. Results. Eighteen individuals with relapsing-remitting MS and 14 age- and sex-matched healthy controls participated. Backward walking velocity revealed significant differences between groups for both single-task (p=0.015) and dual-task (p=0.014) conditions. Persons with MS demonstrated significant differences between single- and dual-task forward and backward walking velocities (p=0.023; p=0.004), whereas this difference was only apparent in the backward walking condition for healthy controls (p=0.004). In persons with MS, there were significant differences in double support time between single- and dual-task conditions in both backward (p<0.001) and forward (p=0.001) directions. More falls at six months were significantly associated with shorter backward dual-task stride length (r=−0.490; p=0.046) and slower velocity (r=−0.483; p=0.050). Conclusion. Differences in MS and age- and sex-matched healthy controls are more pronounced during backward compared to forward walking under single- and dual-task conditions. Future work with a larger sample size is needed to validate the clinical utility of backward walking and dual-task assessments and mitigate the limited sensitivity of the current dual-task assessments that primarily rely upon forward walking.

show abstract

“…The striatum, which shows early and strikingly selective degeneration in HD, [11][12][13] has been suggested to be fundamentally involved in dual tasking. 14 Recent studies in individuals with Parkinson's disease (PD) noted significant associations between greater striatal damage and dual tasking deficits. 15,16 To our knowledge, associations between striatal degeneration and dual tasking have not been investigated in individuals with HD.…”

Section: Introductionmentioning

confidence: 99%

Dual tasking impairments are associated with striatal pathology in Huntington’s disease

Reyes

Pulverenti

et al. 2020

Ann Clin Transl Neurol

View full text Add to dashboard Cite

Background Recent findings suggest that individuals with Huntington’s disease (HD) have an impaired capacity to execute cognitive and motor tasks simultaneously, or dual task, which gradually worsens as the disease advances. The onset and neuropathological changes mediating impairments in dual tasking in individuals with HD are unclear. The reliability of dual tasking assessments for individuals with HD is also unclear. Objectives To evaluate differences in dual tasking performance between individuals with HD (presymptomatic and prodromal) and matched controls, to investigate associations between striatal volume and dual tasking performance, and to determine the reliability of dual tasking assessments. Methods Twenty individuals with HD (10 presymptomatic and 10 prodromal) and 20 healthy controls were recruited for the study. Individuals undertook four single and dual task assessments, comprising motor (postural stability or force steadiness) and cognitive (simple or complex mental arithmetic) components, with single and dual tasks performed three times each. Participants also undertook a magnetic resonance imaging assessment. Results Compared to healthy controls, individuals with presymptomatic and prodromal HD displayed significant deficits in dual tasking, particularly cognitive task performance when concurrently undertaking motor tasks (P < 0.05). The observed deficits in dual tasking were associated with reduced volume in caudate and putamen structures (P < 0.05),however, not with clinical measures of disease burden. An analysis of the reliability of dual tasking assessments revealed moderate to high test–retest reliability [ICC: 0.61‐0.99] for individuals with presymptomatic and prodromal HD and healthy controls. Conclusions Individuals with presymptomatic and prodromal HD have significant deficits in dual tasking that are associated with striatal degeneration. Findings also indicate that dual tasking assessments are reliable in individuals presymptomatic and prodromal HD and healthy controls.

show abstract

Cognitive-Motor Interference in Neurodegenerative Disease: A Narrative Review and Implications for Clinical Management

Cited by 41 publications

References 77 publications

Attention-Demanding Cognitive Tasks Worsen Postural Control in Patients With Cervical Dystonia: A Case-Control Study

Attention-Demanding Cognitive Tasks Worsen Postural Control in Patients With Cervical Dystonia: A Case-Control Study

Backward Walking and Dual-Task Assessment Improve Identification of Gait Impairments and Fall Risk in Individuals with MS

Dual tasking impairments are associated with striatal pathology in Huntington’s disease

Contact Info

Product

Resources

About