Cognitive Profile in Persons With Systolic and Diastolic Heart Failure

Athilingam, Ponrathi; D’Aoust, Rita; Miller, Leslie W.; Chen, Leway

doi:10.1111/chf.12001

Cited by 38 publications

(37 citation statements)

References 39 publications

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“…There are very limited data on evaluation of cognitive function in patients with preserved ejection fraction [33–35]. The study that most directly addresses cognitive impairment in HFpEF patients also used the MoCA instrument [33].…”

Section: Discussionmentioning

confidence: 99%

Hyponatremia, Cognitive Function, and Mobility in an Outpatient Heart Failure Population

et al. 2016

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BackgroundThe association of hyponatremia with cognitive impairment and mobility in heart failure (HF) patients is unknown. The purpose of this study was to determine if hyponatremia is associated with cognitive and mobility impairment as measured by simple, validated, and time-sensitive tests.Material/MethodsThis was a prospective study in patients with reduced and preserved ejection fraction (HFrEF, HFpEF) seen in outpatient HF clinics. Hyponatremia was defined as sodium level ≤136 mEq/L. Cognitive function was measured using the Montreal Cognitive Assessment (MoCA) tool, and mobility was measured with the Timed Up and Go test (TUG-t).ResultsA total of 121 patients were evaluated; 30% were hyponatremic (134±1.9 mEq/l, range 128–136 mEq/l). Overall, 92% of hyponatremic patients had cognitive impairment (MoCA <26) compared to 76% of the non-hyponatremic patients [relative risk 1.2 (confidence interval: 1.02–1.4, p=0.02)]. In regard to mobility, 72% of hyponatremic patients and 62% of non-hyponatremic patients (p=0.4) had TUG-t times that were considered to be worse than average. A total of 84% (N=76) of HFrEF and 71% (N=22) of HFpEF patients had cognitive impairment (p=0.86). HFrEF patients had significantly lower overall MoCA scores (21.2±3.7 vs. 23.3±3.6, p=0.006) and similar TUG-t times compared to HFpEF patients.ConclusionsMost heart failure patients (HFrEF and HFpEF) seen in an ambulatory setting had impairment of cognitive function and mobility, with a higher prevalence among those with hyponatremia. Screening can be done using tests that can be administered in a clinical setting.

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Section: Discussionmentioning

confidence: 99%

Hyponatremia, Cognitive Function, and Mobility in an Outpatient Heart Failure Population

et al. 2016

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“…For quantitative variables arithmetic mean (± standard deviation) or median (interquartile range) were calculated as appropriate, and P values derived from a two-sample t -test (U-Mann–Whitney tests were used for skewed data). For qualitative variables, percentages within specified groups were calculated and P values were derived using Chi [2] tests. All the tests were two-sided; differences were considered significant at the p < 0.05 level.…”

Section: Methodsmentioning

confidence: 99%

“…The prevalence of CI depends on the test used and varies widely among studies, ranging from less than 30 % to more than 80 % [2–7]. As cognitive tests are age-and education sensitive [8] the use of a validated screening test in our population would provide valuable information on CI prevalence.…”

Section: Introductionmentioning

confidence: 99%

Ischemic aetiology, self-reported frailty, and gender with respect to cognitive impairment in chronic heart failure patients

González-Moneo

Sánchez‐Benavides

Verdú-Rotellar

et al. 2016

BMC Cardiovasc Disord

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BackgroundDecisive information on the parameters involved in cognitive impairment in patients with chronic heart failure is as yet lacking. Our aim was to determine the functional and psychosocial variables related with cognitive impairment using the mini-mental-state examination (MMSE) with age-and education-corrected scores.MethodsA cohort study of chronic heart failure patients included in an integrated multidisciplinary hospital/primary care program. The MMSE (corrected for age and education in the Spanish population) was administered at enrolment in the program. Analyses were performed in 525 patients. Demographic and clinical variables were collected. Comprehensive assessment included depression (Yesavage), family function (family APGAR), social network (Duke), dependence (Barthel Index), frailty (Barber), and comorbidities. Univariate and multivariate logistic regression were performed to determine the predictors of cognitive impairment.ResultsCognitive impairment affected 145 patients (27.6 %). Explanatory factors were gender (OR: 2.77 (1.75–4.39) p < 0.001), ischemic etiology (OR: 1.99 (1.25–3.17) p = 0.004), frailty (OR: 1.58 (0.99 to 2.50, p =0.050), albumin > 3.5 (OR: 0.59 (0.35–0.99) p = 0.048), and beta-blocker treatment (OR: 0.36 (0.17 to 0.76, p = 0.007)). No association was found between cognitive impairment and social support or family function.ConclusionThe observed prevalence of cognitive impairment using MMSE corrected scores was 27.6 %. A global approach in the management of these patients is needed, especially focusing on women and patients with frailty, low albumin levels, and ischemic aetiology heart failure.

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“…During recent years, research has shown that cognitive impairment is prevalent in HF, although substantial variability in the pattern of deficits has been reported. 1,2 According to a review by Pressler 3 , 25%e50% of HF patients experience cognitive impairment. Moreover, according to one study, hospitalized HF patients with cognitive impairment have a 5-fold increased mortality.…”

mentioning

confidence: 99%

Frequent Mild Cognitive Deficits in Several Functional Domains in Elderly Patients With Heart Failure Without Known Cognitive Disorders

Nordlund

Berggren

Holmström

et al. 2015

Journal of Cardiac Failure

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Cognitive Profile in Persons With Systolic and Diastolic Heart Failure

Cited by 38 publications

References 39 publications

Hyponatremia, Cognitive Function, and Mobility in an Outpatient Heart Failure Population

Hyponatremia, Cognitive Function, and Mobility in an Outpatient Heart Failure Population

Ischemic aetiology, self-reported frailty, and gender with respect to cognitive impairment in chronic heart failure patients

Frequent Mild Cognitive Deficits in Several Functional Domains in Elderly Patients With Heart Failure Without Known Cognitive Disorders

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