One pathway through which stressors are thought to influence physiology is through their effects on emotion. We used metaanalytic statistical techniques with data from nine studies to test the effects of acute laboratory stressors ( speech, star mirror-image tracing, hand grip) on emotional (undifferentiated negative emotion, angel; anxiety) and cardiovascular (CV) response. In all of the studies, participants responded to stressors with both increased CV response and increased negative emotion. Increases in negative emotion were associated with increases in CV response across tasks, howevel; these associations were small. The range of variance accounted for was between 2% and 12%. Thus, the contribution of negative emotion, as assessed in these studies, to physiological responses to acute laboratory stressors was limited. Although these results raise questions about the role of emotion in mediating stress-elicited physiological responses, the nature of the acute laboratory stress paradigm may contribute to the lack of a strong association.