Defects after resection of the upper jaw lead to communication of the oral cavity with the nasal cavity, chewing disorders, aesthetic problems and other functional disorders. The aim of the study is to assess the dental status and quality of life of elderly patients with upper jaw defects, as a technology of longevity, at the stage of orthopedic rehabilitation. 24 patients were examined, divided into two groups of 12 people aged from 58 to 74 years. The main group – patients after resection of the upper jaw for malignant neoplasms. Buccal epithelial cells and quality of life of patients were studied before and after prosthetics. After orthopedic rehabilitation, there is a tendency to restore the barrier properties of the oral mucosa and improve the quality of life of patients. Orthopedic rehabilitation of patients with upper jaw defects using obturator prostheses is an appropriate and non-invasive method of treatment for the elderly.