Cohort Profile: The Integrated Women’s Health Programme (IWHP): a study of key health issues of midlife Singaporean women

Thu, Win Pa Pa; Logan, Susan; Lim, Christine; Wang, Yue Luna; Cauley, Jane A.; Yong, Eu Leong

doi:10.1093/ije/dyx278

Cited by 20 publications

(23 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…SingHealth Institutional Review Board approval was obtained for this study (CIRB Ref 2018/2574). The dataset consisted of 600 women who had been seen in the outpatient and health screening clinics at Singapore General Hospital; the largest hospital in Singapore and had DXA scans done as a part of their routine work up or had DXA scans done as a part of general health screening and 1201 women, recruited through the gynecology and menopause clinics into the Integrated Women’s Health Programme (IWHP) cohort study at National University Hospital, Singapore [ 14 ]. Menopause was defined as at least 6 months of amenorrhoea for women >55 years and at least >12 months of amenorrhoea for women 50–54 years [ 8 ].…”

Section: Methodsmentioning

confidence: 99%

Comparison of the Osteoporosis Self-Assessment Tool for Asians and the fracture risk assessment tool - FRAX to identify densitometric defined osteoporosis: A discriminatory value analysis in a multi-ethnic female population in Southeast Asia

Chandran

Chin

Choo

et al. 2020

Osteoporosis and Sarcopenia

Self Cite

View full text Add to dashboard Cite

Objectives The accuracy of FRAX® as a screening tool to identify osteoporosis and how it compares with tools such as Osteoporosis Self-Assessment Tool for Asians (OSTA), in Southeast Asian women has so far been unexplored. We aimed to determine the FRAX® thresholds that accurately identify densitometric osteoporosis and to compare its performance with that of OSTA for this purpose. Methods Singaporean postmenopausal women (n = 1056) were evaluated. FRAX® Major Osteoporotic Fracture Probability (MOFP), Hip Fracture Probability (HFP) scores, and OSTA indices were calculated. Receiver operating characteristic (ROC) curves were constructed and via the Youden index, the optimal cut-off points of balanced sensitivity and specificity for dual energy X-ray absorptiometry (DXA)-defined osteoporosis were identified and the performance characteristics were compared. Results A FRAX® MOFP threshold of ≥3.7% had sensitivity, specificity, positive predictive value and negative predictive value of 0.78 (0.73–0.83), 0.63 (0.59–0.66), 0.4 (0.36–0.44), and 0.9 (0.87–0.92), respectively in identifying osteoporosis. The corresponding values for a HFP threshold of ≥0.6% were 0.85 (0.80–0.89), 0.58 (0.55–0.62), 0.39 (0.35–0.43), and 0.92 (0.9–0.94) and that for an OSTA index cut-off of ≤ −1.2 were 0.76 (0.70–0.81), 0.74 (0.71–0.77), 0.48 (0.43–0.54), and 0.91 (0.88–0.93). The area under the ROC curves were 82.8% (79.9%–85.6%), 77.6% (74.2%–81%), and 79.6% (76.5%–82.8%) for OSTA, MOFP, and HFP thresholds respectively. Conclusions FRAX® and OSTA perform comparably in identifying osteoporosis in our population. OSTA has only 2 parameters and may be simpler to use. However, FRAX® may also have a role in primary screening to identify the postmenopausal woman to be referred for DXA scanning and may help facilitate fracture risk reduction discussions with the patient.

show abstract

Section: Methodsmentioning

confidence: 99%

Comparison of the Osteoporosis Self-Assessment Tool for Asians and the fracture risk assessment tool - FRAX to identify densitometric defined osteoporosis: A discriminatory value analysis in a multi-ethnic female population in Southeast Asia

Chandran

Chin

Choo

et al. 2020

Osteoporosis and Sarcopenia

Self Cite

View full text Add to dashboard Cite

show abstract

“…The Integrated Women’s Health Program (IWHP) is a cross-sectional study examining health conditions among Chinese, Malay, and Indian midlife women, aged 45–69 years [ 24 ]. In brief, healthy participants attending well-women clinics were recruited from the National University Hospital, Singapore.…”

Section: Methodsmentioning

confidence: 99%

“…Exclusion criteria included pregnancy or a potentially life-threatening health condition. Further details on the inclusion and exclusion criteria have been published previously [ 24 ]. This study was approved by the Domain Specific Review Board of the National Healthcare Group, Singapore (reference number: 2014/00356), and all participants provided written informed consent.…”

Section: Methodsmentioning

confidence: 99%

“…HGS was measured using a hand-held hydraulic dynamometer (Jamar, Bolingbrook, IL, USA) [ 24 ]. The Jamar dynamometer is widely used to assess grip strength and is the gold standard by which other dynamometers are evaluated [ 25 , 26 ].…”

Section: Methodsmentioning

confidence: 99%

“…Information on sociodemographic, reproductive, and lifestyle factors was self-reported using validated questionnaires, as described previously [ 24 ]. These factors included age, ethnicity, education level, housing type, parity, menopausal status, smoking status, and alcohol consumption.…”

Section: Methodsmentioning

confidence: 99%

See 2 more Smart Citations

The Associations between Upper and Lower Body Muscle Strength and Diabetes among Midlife Women

Wong

Thu²,

Chan³

et al. 2022

IJERPH

View full text Add to dashboard Cite

We hypothesized that a combined index of upper and lower body muscle strength would be more strongly associated with diabetes than either measure alone. Women recruited into the Integrated Women’s Health Program had their handgrip strength (HGS) measured using a dynamometer and underwent a timed 5-repetition chair stand (RCS) test. HGS < 18 kg and RCS performance ≥ 12 s assessed upper and lower body strength, respectively, both individually and combined in a muscle strength index (MSI). Diabetes was defined as physician-diagnosed, use of anti-diabetic medication, or fasting blood glucose ≥ 7.0 mmol/L. Binary logistic regression examined the associations between muscle strength and diabetes. Of 1170 midlife women, 12.1% had diabetes. A low HGS was independently associated with diabetes (aOR: 1.59, 95% CI: 1.03, 2.44). Prolonged RCS was also associated with diabetes (aOR: 1.59, 95% CI: 1.09, 2.30), but this was not independent of visceral adiposity and muscle mass. A poor MSI had higher odds of diabetes (aOR: 2.37, 95% CI: 1.40, 4.03), independent of age, ethnicity, education level, menopausal status, smoking, alcohol consumption, physical activity, height, visceral adiposity, and muscle mass. The combination of both upper and lower body muscle strength into a composite MSI was more strongly associated with diabetes than either weak HGS or prolonged RCS alone in midlife women.

show abstract

Risk factors and prevalence of urinary incontinence in mid-life Singaporean women: the Integrated Women’s Health Program

Thu

et al. 2019

Int Urogynecol J

View full text Add to dashboard Cite

Cohort Profile: The Integrated Women’s Health Programme (IWHP): a study of key health issues of midlife Singaporean women

Cited by 20 publications

References 23 publications

Comparison of the Osteoporosis Self-Assessment Tool for Asians and the fracture risk assessment tool - FRAX to identify densitometric defined osteoporosis: A discriminatory value analysis in a multi-ethnic female population in Southeast Asia

Comparison of the Osteoporosis Self-Assessment Tool for Asians and the fracture risk assessment tool - FRAX to identify densitometric defined osteoporosis: A discriminatory value analysis in a multi-ethnic female population in Southeast Asia

The Associations between Upper and Lower Body Muscle Strength and Diabetes among Midlife Women

Risk factors and prevalence of urinary incontinence in mid-life Singaporean women: the Integrated Women’s Health Program

Contact Info

Product

Resources

About