Cohort Profile: The Metabolic syndrome and Cancer project (Me-Can)

Stocks, Tanja; Borena, Wegene; Strohmaier, Susanne; Bjørge, Tone; Manjer, Jonas; Engeland, Anders; Johansen, Dorthe; Selmer, Randi; Hallmans, Göran; Rapp, Kilian; Concin, Hans; Jonsson, Håkan; Ulmer, Hanno; Stattin, Pär

doi:10.1093/ije/dyp186

Cited by 82 publications

(106 citation statements)

References 19 publications

(20 reference statements)

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“…The Me-Can study design, participating cohorts, and data collection procedures have been described previously (11). Briefly, for studies on female cancers, six cohorts from Austria (the Vorarlberg Health Monitoring and Prevention Programme), Norway (the Norwegian Counties study, the Cohort of Norway, and the Age 40 Programme), and Sweden (the Västerbotten Intervention Project and the Malmö Preventive Project) were pooled in 2006.…”

Section: Study Populationmentioning

confidence: 99%

“…Different resting time before measurements, body positions, and equipment were used in the cohorts for measurement of blood pressure. Also, various fasting times before blood draw were used in the different cohorts (11).…”

Section: Study Populationmentioning

confidence: 99%

“…Evaluation of the association between the MetS and breast cancer incidence and mortality within the same cohort is another major strength. We used data from population-based surveys in three countries, with almost complete coverage of data for measured exposure factors (11). The large number of repeated measurements within the cohort allowed us to adjust for random error in the individual MetS factors (20).…”

Section: Strengths and Limitationsmentioning

confidence: 99%

“…Different measurement methods were used in the individual Me-Can cohorts (11). Anthropometric measurements were conducted similarly in all cohorts, but there were differences with regard to blood pressure measurements and analyses of blood samples.…”

Section: Strengths and Limitationsmentioning

confidence: 99%

“…In 2006, we initiated the MEtabolic syndrome and CANcer (Me-Can) project to investigate the effects of MetS factors and the MetS as an entity on cancer risk (11). Existing long-standing cohorts in Austria, Norway, and Sweden were included in the project.…”

Section: Introductionmentioning

confidence: 99%

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Metabolic Syndrome and Breast Cancer in the Me-Can (Metabolic Syndrome and Cancer) Project

Bjørge

Lukanova

Jonsson

et al. 2010

Cancer Epidemiology, Biomarkers &Amp; Prevention

157

138

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Background: Few studies have assessed the metabolic syndrome (MetS) as an entity in relation to breast cancer risk, and results have been inconsistent. We aimed to examine the association between MetS factors (individually and combined) and risk of breast cancer incidence and mortality.Methods: Two hundred ninety thousand women from Austria, Norway, and Sweden were enrolled during 1974-2005, with measurements of height, weight, blood pressure, and levels of glucose, cholesterol, and triglycerides. Relative risks (RR) of breast cancer were estimated using Cox proportional hazards regression for each MetS factor in quintiles and for standardized levels (z-scores) and for a composite z-score for the MetS.Results: There were 4,862 incident cases of breast cancer and 633 deaths from breast cancer identified. In women below age 50, there was a decreased risk of incident cancer for the MetS (per 1-unit increment of z-score; RR, 0.83; 95% confidence interval, 0.76-0.90) as well as for the individual factors (except for glucose). The lowest risks were seen among the heaviest women. In women above age 60, there was an increased risk of breast cancer mortality for the MetS (RR, 1.23; 95% confidence interval, 1.04-1.45) and for blood pressure and glucose. The strongest association with mortality was seen for increased glucose concentrations.Conclusions: The MetS was associated with a decreased risk of incident breast cancer in women below age 50 with high body mass index, and with an increased risk of breast cancer mortality in women above 60.Impact: Lifestyle interventions as recommended for cardiovascular disease prevention may be of value to prevent breast cancer mortality in postmenopausal women. Cancer Epidemiol Biomarkers Prev; 19(7); 1737-45.

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Section: Study Populationmentioning

confidence: 99%

Section: Study Populationmentioning

confidence: 99%