Cohort Profile: West China Health and Aging Trend (WCHAT)

Hou, Lisha; Liu, Xiaolei; Zhang, Y.; Zhao, Wenchuan; Xia, Xin; Chen, X.; Lin, Xiufang; Yue, Jirong; Ge, Ning; Dong, Birong

doi:10.1007/s12603-020-1530-1

Cited by 37 publications

(43 citation statements)

References 26 publications

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“…2017[445]) and was registered in the Chinese Clinical Trial Registry (ChiCTR1800018895). The design and study protocol of WCHAT have been reported elsewhere [14,15]. In brief, WCHAT was initiated in 2018, and adopted multi-stage random cluster sampling in four provinces in west China, Yunnan, Guizhou, Sichuan and Xinjiang.…”

Section: Study Design and Data Collectionmentioning

confidence: 99%

The prevalence and associated factors of motoric cognitive risk syndrome in multiple ethnic middle‐aged to older adults in west China: a cross‐sectional study

Sun

Harris

Hou

et al. 2022

Euro J of Neurology

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Background and purpose: Motoric cognitive risk (MCR) syndrome characterized by subjective cognitive complaints and slow gait has been proposed and validated as a pre-dementia syndrome. The overall and specific ethnic prevalence of MCR and the associated factors are poorly understood in middle-aged to older community-dwelling residents in west China. Methods:The present study included 6091 samples from the prospective cohort study, West China Health and Aging Trend (WCHAT). Multidimensional factors of demography, lifestyle, social support, anthropometrics and body components, and clinical status were investigated and analyzed by univariate and multivariate logistic regression models. Lasso regression and K-fold cross-validation were conducted to construct the most predictive model with fitted factors. Results:The overall prevalence of MCR was 9.74%, and ethnically the prevalence was 14.25% in Tibetan, 11.03% in Yi, 10.72% in Han, 5.18% in Uighur and 4.55% in Qiang, respectively. In the adjusted models, the positively associated risk factors included diabetes mellitus (odds ratio [OR] = 1.51, p = 0.007), osteoarthritis (OR = 1.50, p = 0.002), depression (OR = 1.36, p = 0.005), poor sleep (OR = 1.21, p = 0.045), comorbidity (OR = 1.49, p = 0.001) and falls in the last 12 months (OR = 1.34, p = 0.031). Of note, every 1-unit increase of value in stroke was associated with an approximate 3-fold higher risk of having MCR, whilst in high-density lipoprotein with a 30% lower risk of MCR,respectively.Conclusions: Profiles of MCR from the aspects of ethnicity and the presenium stage need further exploration. It is a promising strategy to apply MCR as a primary prevention tool to prevent dementia. | 1355 MOTORIC COGNITIVE RISK SYNDROME IN MULTIPLE ETHNICS INTRODUC TI ON An estimated 55 million people are currently living with dementia globally [1], with forecasts reaching 78 million by 2030 and 152 million by 2050, 60%-80% of which can be attributed to Alzheimer's disease (AD) [1-3]. The Alzheimer's Disease International estimated that 75% of individuals with dementia are not diagnosed and 90% of them are in undeveloped and underdeveloped regions and countries [1]. Dementia is a disease with multifactorial etiology and heterogeneous clinical presentation and disease trajectory. Also, dementia has a long preclinical phase from several years to decades before the cognitive alterations indicating mild cognitive impairment (MCI) are detectable [3,4]. Motoric cognitive risk (MCR) syndrome was proposed and validated in 2013 by Verghese and colleagues to identify aging individuals at high risk for dementia during the pre-dementia stage [5,6]. Approximately 10% of older persons are affected by MCR worldwide [7]. This syndrome integrates two specific harbingers of dementia, subjective cognitive complaints (SCC) and slow gait speed (SG), in the absence of mobility disability and dementia [5,6]. MCR was found to be more strongly associated with cognitive decline or dementia than either of these two harbingers alone [3,8]. Cognitive fun...

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Section: Study Design and Data Collectionmentioning

confidence: 99%

The prevalence and associated factors of motoric cognitive risk syndrome in multiple ethnic middle‐aged to older adults in west China: a cross‐sectional study

Sun

Harris

Hou

et al. 2022

Euro J of Neurology

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“…Data were based on the baseline of West China Health and Aging Trend (WCHAT) study, a population-based longitudinal study of aging and health of community-dwelling Chinese aged 50 and older in western China [19]. The cohort study began in 2018 and was approved by the Ethics Committee of West China Hospital, Sichuan University (reference: 2017-445) and was conducted in accordance with the 2013 version of the Declaration of Helsinki.…”

Section: Study Design and Sample Selectionmentioning

confidence: 99%

Long sleep duration is associated with cognitive frailty among older community-dwelling adults: results from West China Health and Aging Trend study

Zhao

et al. 2021

BMC Geriatr

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Objective To investigate the association between sleep duration and cognitive frailty among older adults dwelling in western China. Methods We used the baseline data from West China Health and Aging Trend (WCHAT) study. Sleep duration was classified as short sleep duration (< 6 h), normal sleep duration (6–8 h) and long sleep duration (≥ 9 h). Fried frailty criteria and Short Portable Mental Status Questionnaire were used to measure cognitive frailty. Multinomial logistic regression was conducted to estimate odds ratio (OR) and 95% confidence interval (CI). Results A total of 4093 older adults (age = 67.8 ± 5.9 years, 1708 males and 2385 females) were included in the analysis. The prevalence of cognitive frailty was 11.8% among older adults in western China. Approximately 11.9% participants had short sleep duration (< 6 h); 22.2% had a long sleep duration (≥ 9 h). After adjusting for covariates, only long sleep duration was significantly associated with high risk of cognitive frailty (OR = 2.07, 95%CI = 1.60–2.68, P < 0.001) in western China older adults compared to normal sleep duration. Conclusions Long sleep duration was significantly related to cognitive frailty in older adults. Intervention for long sleep duration may be helpful to prevent cognitive frailty. Trial registration Chinese Clinical Trial Registry: ChiCTR1800018895.

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“…Data were based on the baseline of West China Health and Aging Trends study (WCHAT), a cohort study designed to assess the health status and its influencing factors in West China [ 18 ]. The study was conducted in 2018 and approved by the Ethics Committee of West China Hospital, Sichuan University (reference: 2017 − 445).…”

Section: Methodsmentioning

confidence: 99%

Vitamin D status and obesity markers in older adults: results from West China Health and Aging Trends study

Zhao

Qin

et al. 2021

BMC Geriatr

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Backgrounds Vitamin D deficiency and insufficiency in older adults seems to be common, but the prevalence estimates are lacking in West China. Previous studies suggested that low vitamin D status was associated with obesity. However, most of them evaluated obesity based on body mass index (BMI) and there are no studies at present exploring the association between vitamin D status and different obesity markers. The present study aims to investigate the prevalence of low vitamin D status and evaluate the association between the vitamin D status and different obesity markers among older adults in West China. Methods Data was based on the baseline of West China Health and Aging Trends study (WCHAT). All of the participants were older than 60 years old in the present study. Vitamin D status was based on laboratory data, and obesity markers were assessed by bioelectrical impedance analysis (BIA) using the InBody 770 analyzer. Multiple linear regression was performed to find the association between the vitamin D status and various obesity markers. Results The study included 2661 individuals (mean age: 67.7 ± 6.0 years; males: 41 %). The mean vitamin D level was 18.8 ± 6.3 ng/ml (range: 5 to 59 ng/ml); 5.2 % of participants had a sufficient level of vitamin D, 31.8 % had vitamin D insufficiency, and 63.0 % had vitamin D deficiency. Our results showed that vitamin D status was negatively associated with fat mass index (FMI), visceral fat area (VFA), and waist-hip ratio (WHR) in both sexes. Comparing to other obesity markers, WHR had the strongest correlation with vitamin D status in both sexes (β = -6.090, P = 0.046 in males; β = -11.253, P < 0.001 in females). No significant association was found between vitamin D status and BMI in males. Conclusion The prevalence of vitamin D insufficiency and deficiency among older adults in West China was high. Among the older adults in west China, WHR showed stronger association with vitamin D status and was better for the prediction of vitamin D insufficiency or deficiency in both sexes, compared to BMI. Trial registration Chinese Clinical Trial Registry: ChiCTR1800018895.

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Cohort Profile: West China Health and Aging Trend (WCHAT)

Cited by 37 publications

References 26 publications

The prevalence and associated factors of motoric cognitive risk syndrome in multiple ethnic middle‐aged to older adults in west China: a cross‐sectional study

The prevalence and associated factors of motoric cognitive risk syndrome in multiple ethnic middle‐aged to older adults in west China: a cross‐sectional study

Long sleep duration is associated with cognitive frailty among older community-dwelling adults: results from West China Health and Aging Trend study

Vitamin D status and obesity markers in older adults: results from West China Health and Aging Trends study

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