Cohort study of predictive value of urinary albumin excretion for atherosclerotic vascular disease in patients with insulin dependent diabetes

The effects of insulin and short-term hyperglycaemia on myocardial blood flow in young men with uncomplicated Type I diabetes

“…Chronic hyperglycaemia might also increase the risk for coronary artery disease by many mechanisms, such as abnormalities in lipoprotein particle composition, irreversible glycation of proteins in the arterial wall [54], acceleration of thrombus formation [54] and oxidation of lipoproteins [55] or worsening of insulin resistance and hyperinsulinaemia [56]. Consistent with that many [20,21,22,23] but not all studies [57,58] have found that higher HbA 1c is a predictor for macrovascular complications. We found that HbA 1c was inversely associated with hyperaemic adenosine stimulated myocardial blood flow in the pooled data but not in the diabetic or non-diabetic subjects alone.…”

Circulating endothelial progenitor cells, endothelial function, carotid intima–media thickness and circulating markers of endothelial dysfunction in people with type 1 diabetes without macrovascular disease or microalbuminuria

“…In the current study we chose to study young adults with type 1 diabetes, so the population is very similar in characteristics to the control non-diabetic group, except for measures of hyperglycaemia. Exclusion of those with extant cardiovascular disease or diabetic nephropathy was designed to avoid participants in whom vascular injury was already advanced and in whom endothelial repair mechanisms might therefore have been activated by arterial wall damage in the form of atherosclerotic plaque [39][40][41]. Nevertheless it is impossible to be sure that some individuals in our type 1 diabetic population did not have more significant disease (indeed in both populations).…”

Relationship between glyco-oxidation, antioxidant status and microalbuminuria in type 2 diabetic patients

“…the main determinants of morbidity and mortality in type 1 [1] and type 2 diabetic patients [2]. In both types of diabetes, microalbuminuria is related to increases in a number of markers of endothelial dysfunction [3,4], which is why microalbuminuria is considered a marker of the risk of atherosclerosis and cardiovascular disease [5].…”