2023
DOI: 10.1098/rsob.230192
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Coiled-coil-mediated dimerization of Atg16 is required for binding to the PROPPIN Atg21

Miranda Bueno-Arribas,
Celia Cruz-Cuevas,
María-Angeles Navas
et al.

Abstract: PROPPINs/WIPIs are β-propeller proteins that bind phosphoinositides and contribute to the recruitment of protein complexes involved in membrane remodelling processes such as autophagosome formation and endosomal trafficking. Yeast Atg21 and mammalian WIPI2 interact with Atg16/ATG16L1 to mediate recruitment of the lipidation machinery to the autophagosomal membrane. Here, we used the reverse double two-hybrid method (RD2H) to identify residues in Atg21 and Atg16 critical for protein–protein binding. Although ou… Show more

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