Coincident detection of lung metastasis of prostate cancer and primary lung cancer: A case report

Muro, Yusuke; Kosaka, Takeo; Hato, Tai; Mikami, Shuji; Oya, Mototsugu

doi:10.5489/cuaj.2376

Cited by 2 publications

(1 citation statement)

References 9 publications

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“…Prostate cancer may metastasize to any organ, including bones, lymph nodes, and lungs. Although lung metastases have been reported in >40% of patients with prostate cancer ( 3 - 7 ), cases of isolated lung metastases without concurrent bone or lymph node metastases are uncommon. In the current patient, a 12 mm × 14 mm round solid nodule in the right upper lobe was detected during physical examination.…”

Section: Discussionmentioning

confidence: 99%

A prostate cancer patient with isolated lung metastases: a case report

Wu¹,

Lei²,

Zhu³

et al. 2020

Transl Cancer Res TCR

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Pulmonary involvement has been reported in >40% of autopsy series in patients with metastatic prostate cancer; however, isolated lung metastases have been documented in <1% of cases and 43.5%(10/23) cases underwent surgical resection and most of them have good outcome. We present a 74-year-old male Gleason high-grade prostate cancer patient with initially negative PSA and isolated pulmonary lesion which was confirmed as lung metastasis by resection. This patient received first-line endocrine therapy with leuprolide and bicalutamide endocrine and had a long-term disease-free follow-up of 3 years. The present patient had isolated lung metastasis with negative PSA, which was very rare in literature. Unexpected longterm disease-free survival was achieved after first-line endocrine therapy in this case with Gleason score of 8 metastatic prostate cancer. Whether or not the path of metastasis in this case was via lymph node jumping (negative lymph node dissection) or hematogenous (usually multiple, in bilateral lungs and lower lung fields) requires further investigation.

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Section: Discussionmentioning

confidence: 99%

A prostate cancer patient with isolated lung metastases: a case report

Wu¹,

Lei²,

Zhu³

et al. 2020

Transl Cancer Res TCR

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Metachronous Single Pulmonary Metastasis of Prostate Cancer: Report of a Rare Case and Literature Review

Kokkalis

Samara

Papadopoulos

et al. 2023

CDP

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Background: Prostate cancer recurrence after definitive local therapy usually involves the bone and regional lymph nodes. Case Report: We present the case of a 72-year-old male patient with an isolated lung nodule, seven years after radical prostatectomy for prostate cancer, pT2bN0 and Gleason score 7(4+3), and prostatic-specific antigen (PSA) levels within normal limits. The nodule was considered as a primary lung cancer and the patient was subjected to lobectomy. The immunohistochemical staining showed that the tumor was PSA(+) and NKX3.1 (+), revealing that it was metastasis from prostatic cancer and that wedge resectomy was the proper procedure. Three years later the patient is disease-free, suggesting the importance of aggressive treatment of oligometastatic disease. Conclusion: Metastasis to the lung is present in more than 40% of men with metastatic prostate cancer; however, lung metastases without any bone or lymph node involvement are extremely rare and only a handful of cases are reported in the literature. Surgical excision of the metastatic lung site is the most common therapeutic approach associated with a good prognosis.

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Coincident detection of lung metastasis of prostate cancer and primary lung cancer: A case report

Cited by 2 publications

References 9 publications

A prostate cancer patient with isolated lung metastases: a case report

A prostate cancer patient with isolated lung metastases: a case report

Metachronous Single Pulmonary Metastasis of Prostate Cancer: Report of a Rare Case and Literature Review

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