Coincident primary breast lymphoma and gastrointestinal stromal tumor: case series and molecular mechanisms

Ludmir, Ethan B.; Gutschenritter, Tyler; Pinnix, Chelsea C.; Gunther, Jillian R.; Nastoupil, Loretta J.; Khoury, Joseph D.; Medeiros, L. Jeffrey; Dabaja, Bouthaina S.; Milgrom, Sarah A.

doi:10.2147/ott.s159843

Cited by 3 publications

(2 citation statements)

References 28 publications

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“…Ludmir et al described two cases of GIST and primary breast lymphoma (PBL) that occurred simultaneously. Given the dubiousness of the co-occurrence of such rare tumors, there may be a common underlying variation driving both lesions, leading to speculation that these cancers may share common antiapoptotic pathways [3]. However, in our case, the patient was found to have breast carcinoma, not lymphoma.…”

Section: Discussionmentioning

confidence: 65%

Coincident Double Tumor of the Breast and Gastrointestinal Stroma: A Rare Case Report

Mastud¹,

Lamture²,

Nagtode³

et al. 2022

Cureus

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The most common metastasis sites of malignant stromal tumors are the liver, peritoneum, lung, and bones. Metastasis to the breast is extremely rare. Therefore, this is a very rare combination. Both being primary concomitantly is a further rare combination. Gastrointestinal stromal tumors (GISTs) and other primary carcinomas in the same patient are not unusual, and they are frequently discovered by chance. GISTs are uncommon mesenchymal tumors of the gastrointestinal (GI) system. There is a scarcity of information on the prevalence of mesenchymal tumors and other primary tumors in the literature. Therefore, more studies are required to establish the same. Concomitant GISTs accompany the most prevalent epithelial malignancies of the gastrointestinal system. More research is needed to shed insight into the molecular and genetic pathways of GIST and synchronous tumor oncogenesis and progression. This case report brings to light a synchronous double tumor of the breast and gastrointestinal stroma.

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Section: Discussionmentioning

confidence: 65%

Coincident Double Tumor of the Breast and Gastrointestinal Stroma: A Rare Case Report

Mastud¹,

Lamture²,

Nagtode³

et al. 2022

Cureus

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“…Among GIT tumors, tumors of the stomach and esophagus are observed more frequently. Other tumors that may accompany GISTs in the group of MPTs include lymphoma, prostate, kidney, lung carcinomas, NET, and less frequently melanoma, soft tissue, and bone sarcomas [ 4 , 6 , 9 , 12 , 19 , 20 ]. In our study, while GISTs were more frequently localized in the stomach and small intestine, other tumors were localized in the stomach, transverse colon, left colon, rectum, gallbladder, kidney, and retroperitoneal space.…”

Section: Discussionmentioning

confidence: 99%

An entity that should be kept in mind: Synchronous gastrointestinal stromal tumor encountered in resection materials obtained for the detection of intra-abdominal malignancies

Erhan¹

2023

North Clin Istanbul

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OBJECTIVE Gastrointestinal stromal tumors (GISTs), often sporadic, arise from interstitial Cajal cells of the gastrointestinal tract or their stem cell-like precursors. Apart from tumor-associated syndromes, it has been reported that GISTs are also associated with other tumors. There is no clear information about the etiology of these synchronous tumors. In this study, we wanted to present the clinicopathological features of 13 cases diagnosed as synchronous GIST with other tumors. METHODS Demographic characteristics of the cases, risk of progressive disease score, tumor localization, size, and the mitotic activity of tumors along with survival status were evaluated. RESULTS Thirteen of 101 cases diagnosed with GIST had a primary tumor synchronous with GIST. Synchronous GISTs were located in the stomach and small intestine. Most of the cases were detected incidentally in the intraoperative and post-operative periods. Risk scores for progressive disease were categorized as low (n=1), very low (n=1), and no risk (n=11). Non-GIST tumors were located in the stomach, transverse colon, left colon, rectum, gallbladder, kidney, and retroperitoneal space. Histological tumor types were adenocarcinoma, diffuse large B-cell lymphoma, mesothelioma, and neuroendocrine tumor. Life expectancy was found to be significantly lower in synchronous GISTs. CONCLUSION In cases operated for non-GIST tumors, the possibility of incidental detection of GIST should always be kept in mind.

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Frequency, localization, and types of gastrointestinal stromal tumor-associated neoplasia

Waidhauser¹,

Bornemann²,

Trepel

et al. 2019

WJG

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BACKGROUND In recent years, increasing evidence of second neoplasms associated with gastrointestinal stromal tumors (GIST) has been found. Numerous case reports, mostly retrospective studies and a few reviews, have been published. To our knowledge, however, no systematic review or meta-analysis of the existing data has been performed so far. AIM To prepare a compilation, as complete as possible, of all reported second tumor entities that have been described in association with GIST and to systematically analyze the published studies with regard to frequency, localization, and types of GIST-associated neoplasms. METHODS The MEDLINE and EBSCO databases were searched for a combination of the keywords GIST/secondary, synchronous, coincident/tumor, neoplasm, and relevant publications were selected by two independent authors. RESULTS Initially, 3042 publications were found. After deletion of duplicates, 1631 remained, and 130 papers were selected; 22 of these were original studies with a minimum of 20 patients, and 108 were case reports. In the 22 selected studies, comprising a total number of 12050 patients, an overall rate of GIST-associated neoplasias of 20% could be calculated. Most second neoplasias were found in the gastrointestinal tract (32%) and in the male and female urogenital tract (30%). The specific risk scores of GISTs associated with other tumors were significantly lower than those without associated neoplasias. CONCLUSION In this first systematic review, we could confirm previously reported findings of a more than coincidental association between GIST and other neoplasias. The question whether there is an underlying causal association will need further investigation. Our data suggest that even GIST with a very low risk of disease progression should prompt screening for second neoplasia and subsequent frequent controls or extended staging.

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Coincident primary breast lymphoma and gastrointestinal stromal tumor: case series and molecular mechanisms

Cited by 3 publications

References 28 publications

Coincident Double Tumor of the Breast and Gastrointestinal Stroma: A Rare Case Report

Coincident Double Tumor of the Breast and Gastrointestinal Stroma: A Rare Case Report

An entity that should be kept in mind: Synchronous gastrointestinal stromal tumor encountered in resection materials obtained for the detection of intra-abdominal malignancies

Frequency, localization, and types of gastrointestinal stromal tumor-associated neoplasia

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