Coincidental polycythemia vera and multiple myeloma: Case report and review

Fink, L. M.; Bauer, Frank; Perry, James J.

doi:10.1002/ajh.2830440311

Cited by 21 publications

(15 citation statements)

References 26 publications

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“…Multiple myeloma and polycythemia vera or erythrocytosis occurring in the same patient is rare, with about 20 case reports found in English literature (3)(4)(5). Since multiple myeloma may occur simultaneously with erythrocytosis(3), it is not possible for multiple myeloma to be the therapy-related malignancy after treatment of PV.…”

Section: Discussionmentioning

confidence: 96%

Concurrence of Multiple Myeloma and Idiopathic Erythrocytosis

Chang

Shih

2009

Acta Clinica Belgica

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The association of erythrocytosis and multiple myeloma is rare. We encountered a 76-year-old male patient with erythrocytosis followed by the diagnosis of multiple myeloma 8 months later. Related laboratory examinations revealed absolute erythrocytosis, normal oxygen saturation and erythropoietin (EPO) levels, the absence of endogenous erythroid colony (EEC) and JAK2-V617F mutations. The diagnosis of idiopathic erythrocytosis (IE), instead of polycythemic vera (PV), was made. In the literature, about 20 cases of erythrocytosis associated with myeloma can be found. Based on elevated EPO levels, 2 of such cases should be considered secondary erythrocytosis while others are reported as PV. None of them is considered to be have idiopathic erythrocytosis. Our present case is the first one with multiple myeloma developing in a patient with the diagnosis well established by extensive laboratory workup. The pathogenic role of these two entities remains to be established.

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Section: Discussionmentioning

confidence: 96%

Concurrence of Multiple Myeloma and Idiopathic Erythrocytosis

Chang

Shih

2009

Acta Clinica Belgica

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“…Concurrent manifestation of two chronic-phase myeloid and lymphoid neoplasms in one patient is rare and occurs in approximately 1% of patients [11,12]. Several case reports and a few case series have addressed this issue [13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56,57,58,59,60,61,62,63,64,65,66,67,68,69,70,71,72,73,74,75,76,77,78,79,80,81,82,83,84,85,86,87,88,89,90,91]. Due to its rarity, there has been no systematic evaluation of which combinations of myeloid and lymphoid neoplasms are frequent/infrequent, and it is still a matter of debate whether two concurrent diseases in one patient are clonally related or represent independent aberrations.…”

Section: Introductionmentioning

confidence: 99%

Simultaneous and Sequential Concurrent Myeloproliferative and Lymphoproliferative Neoplasms

Jonigk

Kreipe

et al. 2012

Acta Haematol

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Concurrent manifestation of two chronic-stage myeloid and lymphoid/plasmacytoid neoplasms in one patient is rare and occurs in ≤1% of patients. There has been no systematic analysis of which combinations are frequent/infrequent and whether two concurrent diseases in one patient are clonally related or represent independent diseases. We therefore characterised a series of cases from our own archive (n = 65) and collected a large number of previously reported cases of patients in whom myeloid and lymphoid/plasmacytoid neoplasms co-occurred (n = 185). The most frequent combination was Philadelphia chromosome-negative myeloproliferative neoplasm with concurrent B cell chronic lymphocytic leukaemia, accounting for approximately 50% of double-disease patients. We compared the quantity of unsorted bone marrow cell-derived JAK2^V617F and KIT^D816V alleles with the quantity of the lymphoid/plasmacytoid compartment and analysed a subfraction of cases with fluorescence in situ hybridisation. Although a common aberrant progenitor has been reported in some cases in the literature, we found evidence of two independent chronic-stage myeloid and lymphoid/plasmacytoid neoplasms.

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“…The underlying condition causing secondary erythrocytosis in this paAnemia is a common laboratory feature of plasma cell myeloma (PCM) [1] . However, the association between marked erythrocytosis and PCM has been rarely described [2][3][4][5][6][7][8][9][10][11] ; most of the cases were reported prior to the JAK2 era. In this study, we report a rare case of smoldering PCM with coincidental JAK2 V617F and exon 12 mutation-negative secondary erythrocytosis.…”

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confidence: 99%

“…To our knowledge, 18 cases of erythrocytosis associated with PCM were previously described in the literature [2][3][4][5][6][7][8][9][10][11] . Among these, 14 cases were diagnosed with polycythemia vera (PV), 2 cases with questionable secondary erythrocytosis, 1 case with secondary erythrocytosis, and 1 case with idiopathic erythrocytosis ( table 1 ).…”

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confidence: 99%