A lot of coronavirus disease 2019 (COVID-19) related deaths were reported in Yemen about what risk factors contributing to this excess death? Hodeidah governorate at Western part of Yemen exposed to COVID-19 pandemic like other governorates in Yemen, adding to the current chronic diseases’ problems and endemic of vector – borne diseases namely malaria and dengue. The aim of this case report is to explore more data about COVID-19 – dengue fever coinfection related deaths in Hodeidah, Yemen, with both infections cause high mortality rates. The case reported here shows a 25 ‐year‐old male, cough, hypoxia, fever 38°C, difficult in breathing, and bleeding from nose as major of symptoms with oxygen saturation (O2) of 70%, 30 ipm of respiratory rate (RR), 120/80 mmHg of blood pressure, and 120 bpm of heart rate (HR). The patient was diagnosed with bilateral asymmetrical consolidative change with ground glass opacification based X–ray, the leukocytosis, lymphopenia, neutrophilia, and thrombocytopenia were reported. The level of random blood sugar (RBS) was normal, increase in liver enzyme was observed. Mild increase in serum creatinine with C – reactive protein (CRP) was high reactivity with positive COVID-19 and hemorrhagic dengue fever. The patient passed away (death) within two hours in triage. In conclusion , the co-infections with other infection like dengue is of high concern and this is the first reported case of COVID-19 and dengue coinfection presented as stroke and highlights the complex context of diagnostic and therapeutic management in tropical settings such as Hodeidah, Yemen.