Coinfection of gastric mucosa with Helicobacter Pylori and Epstein-Barr virus as a factor of ineffectiveness of antihelicobacter chronic gastritis therapy in adolescents

Abstract

Aim. To assess the character of bacterial-viral infection of the gastric mucosa and dynamics of inflammatory process in adolescents with chronic gastritis in case of antihelicobacter therapy failure.
 Materials and methods. Seventy two adolescents with chronic gastritis aged 11–18 years (mean age 13.8 ± 0.4) were examined prior to and after antihelicobacter therapy.
 Results. It was established that after treatment against the background of regression of clinical symptoms, in most patients no positive dynamics of process manifestation or its progression was noted both in the body and antral part of the stomach.
 Conclusions. In the absolute majority of adolescents with the absence of Hp eradication (78.7 %) there was observed colonization with positive Hp strains and persistence of Epstein-Barr virus (68.1 %). It allows considering patients with such co-infection as a risk group for the absence of Hp eradication.

Role of genetic structure of Helicobacter Pylori in formation of chronic inflammatory process in gastric mucosa

“…При морфологическом исследовании этой категории пациентов регистрируются более выраженные изменения СОЖ, что проявляет ся дистрофией поверхностного эпителия, повышением числа межэпителиальных лим фоцитов, инфильтрацией собственной пла стинки [29][30][31]. Сочетанная колонизация сли зистой желудка Нр и ВЭБ -фактор неэффек тивности антихеликобактерного лечения [32].…”