Aim. To assess the character of bacterial-viral infection of the gastric mucosa and dynamics of inflammatory process in adolescents with chronic gastritis in case of antihelicobacter therapy failure. Materials and methods. Seventy two adolescents with chronic gastritis aged 11–18 years (mean age 13.8 ± 0.4) were examined prior to and after antihelicobacter therapy. Results. It was established that after treatment against the background of regression of clinical symptoms, in most patients no positive dynamics of process manifestation or its progression was noted both in the body and antral part of the stomach. Conclusions. In the absolute majority of adolescents with the absence of Hp eradication (78.7 %) there was observed colonization with positive Hp strains and persistence of Epstein-Barr virus (68.1 %). It allows considering patients with such co-infection as a risk group for the absence of Hp eradication.

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Aim. To characterize the inflammatory process in gastric mucosa among adolescents with chronic gastritis in different variants of its bacterioviral infection. Materials and methods.Clinicoanamnestic, laboratory, endoscopic and morphological examination of 200 adolescents (age range 12–18 years) with chronic gastritis was carried out. In all patients, clinicoanamnestic data, standard laboratory study, esophagogastroduodenoscopy, gastrobiopsy followed by morphological analysis with visual analogue scale were assessed. According to the results of examination, all adolescents were divided into 4 groups depending on the character of bacterioviral infection of gastric mucosa. Results. No statistically significant differences were detected while comparing the rate of clinical manifestations of pain abdominal, dyspeptic, intoxication and asthenovegetative syndromes as well as changes, revealed in laboratory and ultrasound studies in the above mentioned groups of adolescents. Maximal presentation of macroscopic and pathohistological changes was registered in patients of group 4 (association between colonization of GM with highly pathogenic Hp strains and EBV persistence). Conclusions. The character of bacterioviral infection of gastric mucosa significantly determines the manifestation degree and activity of inflammatory process. The least degree of manifestation and activity of inflammatory process is registered when mucosa is colonized by low pathogenic Hp strains. Maximal presentation of macroscopic and pathohistological changes in the gastric mucosa is registered in adolescents with associated infection by high pathogenic Hp strains and Epstein-Barr virus. It is manifested by domination of marked and highly active inflammation and appearance of the signs of mucosal atrophy of gastric body and antrum.

The aim of the work. To establish the features of clinical manifestations and pathomorphology of gastric mucosa in Hp - associated chronic gastritis in adolescents, depending on the genetic characteristics of Hp. Patients and methods. In 133 adolescents with Hp-associated gastritis, polymerase chain reaction was used to determine the presence of pathogenicity factors in the HP genome. Results. In 60,9% of cases, highly pathogenic strains of Helicobacter pylori containing genes Cag (A, C, E, F, H, M, T), UreB, UreI, VacAs1, IceA, BabA, hpaA, AlpB and OipA are detected. Conclusion. The presence of highly pathogenic strains of Hp does not affect the clinical manifestations of gastritis, but is associated with high rates of contamination, increased inflammation, the appearance of signs of atrophy of the gastric mucosa.