Coital and Estrogen Signals: A Contrast in the Preovulatory Neuroendocrine Networks of Rabbits and Rhesus Monkeys1

Spies, Harold G.; Pau, K.-Y. Francis; Yang, Shu

doi:10.1095/biolreprod56.2.310

Cited by 45 publications

(24 citation statements)

References 139 publications

(153 reference statements)

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“…Therefore, there was no concern that the animal would not be ovulating during mating attempts. This allowed investigators much freedom when mating animals in a laboratory setting [67].…”

Section: The New Zealand White Rabbit As a Modelmentioning

confidence: 99%

Regeneration of Uterine Horn Using Porcine Small Intestinal Submucosa Grafts in Rabbits

Taveau

Tartaglia

Buchannan

et al. 2004

Journal of Investigative Surgery

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Tubal factor infertility may be reversed using porcine small-intestinal submucosa (SIS). The method uses as a model the New Zealand White rabbit uerine horn. In surgery, SIS grafts were prepared from porcine jejunum; the uterine horn segment was resected and a graft was placed; then the contralateral adnexa was resected. Fecundability was tested with natural mating. Three out of six rabbits became pregnant. Gross and microscopic examination confirmed regeneration of all tissue layers. Thus, this study determined that SIS facilitates successful regeneration of uterine horn morphology in a manner similar to that observed in other tissues and species.

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“…Therefore, there was no concern that the animal would not be ovulating during mating attempts. This allowed investigators much freedom when mating animals in a laboratory setting [67].…”

Section: The New Zealand White Rabbit As a Modelmentioning

confidence: 99%

Regeneration of Uterine Horn Using Porcine Small Intestinal Submucosa Grafts in Rabbits

Taveau

Tartaglia

Buchannan

et al. 2004

Journal of Investigative Surgery

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“…Most of this work has been done in spontaneous ovulators, including rats (9,25,93,133,153) and monkeys (reviewed in 208). To date, the rabbit (reviewed in 179,208) and ferret (120,229) are the only induced ovulating species in which pharmacological studies have been conducted to analyze the neuroendocrine signals which control the postcoital release of GnRH from the MBH. Norepinephrine, neuropeptide Y, and opioid peptides are the best studied neurotransmitter/neuropeptides in this context.…”

Section: Neurotransmitters and Neuropeptides Involved In The Preovulamentioning

confidence: 99%

Neuroendocrine Regulation of GnRH Release in Induced Ovulators

Bakker

Baum

2000

Frontiers in Neuroendocrinology

180

135

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GnRH is the key neuropeptide controlling reproductive function in all vertebrate species. Two different neuroendocrine mechanisms have evolved among female mammals to regulate the mediobasal hypothalamic (MBH) release of GnRH leading to the preovulatory secretion of LH by the anterior pituitary gland. In females of spontaneously ovulating species, including rats, mice, guinea pigs, sheep, monkeys, and women, ovarian steroids secreted by maturing ovarian follicles induce a pulsatile pattern of GnRH release in the median eminence that, in turn, stimulates a preovulatory LH surge. In females of induced ovulating species, including rabbits, ferrets, cats, and camels, the preovulatory release of GnRH, and the resultant preovulatory LH surge, is induced by the receipt of genital somatosensory stimuli during mating. Induced ovulators generally do not show "spontaneous" steroid-induced LH surges during their reproductive cycles, suggesting that the positive feedback actions of steroid hormones on GnRH release are reduced or absent in these species. By contrast, mating-induced preovulatory surges occasionally occur in some spontaneously ovulating species. Most research in the field of GnRH neurobiology has been performed using spontaneous ovulators including rat, guinea pig, sheep, and rhesus monkey. This review summarizes the literature concerning the neuroendocrine mechanisms controlling GnRH biosynthesis and release in females of several induced ovulating species, and whenever possible it contrasts the results with those obtained for spontaneously ovulating species. It also considers the adaptive, evolutionary benefits and disadvantages of each type of ovulatory control mechanism. In females of induced ovulating species estradiol acts in the brain to induce aspects of proceptive and receptive sexual behavior. The primary mechanism involved in the preovulatory release of GnRH among induced ovulators involves the activation of midbrain and brainstem noradrenergic neurons in response to genital-somatosensory signals generated by receipt of an intromission from a male during mating. These noradrenergic neurons project to the MBH and, when activated, promote the release of GnRH from nerve terminals in the median eminence. In contrast to spontaneous ovulators, there is little evidence that endogenous opioid peptides normally inhibit MBH GnRH release among induced ovulators. Instead, the neural signals that induce a preovulatory LH surge in these species seem to be primarily excitatory. A complete understanding of the neuroendocrine control of ovulation will only be achieved in the future by comparative studies of several animal model systems in which mating-induced as well as spontaneous, hormonally stimulated activation of GnRH neurons drives the preovulatory LH surge. KEY WORDS: GnRH; MBH; induced ovulators; neuroendocrine regulation; preovulatory LH surge; spontaneous ovulators. © 2000 Academic Press Address correspondence and reprint requests to M. J. Baum at Dept. Biology, Boston University, 5 Cummington Street, Boston...

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“…In contrast, ovulation in induced ovulators does not occur at regular intervals, but rather in response to a copulatory stimulus. Induced ovulators include camelid species (Marie & Anouassi 1986, Bravo et al 1992, Bravo 1994, domestic cats (Banks & Stabenfeldt 1982), rabbits (Spies et al 1997), koalas (Johnston et al 2004), bushtail opossum (Crawford et al 1998), voles (Clulow & Mallory 1970, Carter et al 1988, bears (Boone et al 2004), and ferrets (Carroll et al 1985, Bakker & Baum 2000. The line that distinguishes spontaneous and induced ovulators is often blurred as copulation has been reported to influence ovarian function in some spontaneously ovulating species.…”

Section: Introductionmentioning

confidence: 99%

Evidence for the conservation of biological activity of ovulation-inducing factor in seminal plasma

Bogle¹,

Ratto²,

Adams³

2011

Reproduction

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An ovulation-inducing factor (OIF) in the seminal plasma of llamas and alpacas (induced ovulators) and cattle (spontaneous ovulators) suggests that OIF is a conserved constituent of seminal plasma among mammals. In this study, three experiments were designed to determine the biological effects of OIF in different species. In experiment 1, superstimulated prepubertal female CD-1 mice (nZ36 per group) were given a single 0.1 ml i.p. dose of 1) phosphate-buffered saline (PBS), 2) 5 mg gonadotropin-releasing hormone (GNRH), 3) 5 IU hCG, or 4) llama seminal plasma. The proportion of mice that ovulated was similar among groups treated with GNRH, hCG, or seminal plasma, and all were higher than the saline-treated group (P!0.001). In experiment 2, female llamas (nZ8 or 9 per group) were intramuscularly treated with 1) 2 ml PBS, 2) 1 ml diluted llama seminal plasma, 3) 3 ml equine seminal plasma, or 4) 3 ml porcine seminal plasma. Experiment 3 was the same as experiment 2 except that the dose of equine and porcine seminal plasma was increased to 8 and 10 ml respectively. All llamas that were treated with llama seminal plasma ovulated and none that were treated with saline ovulated (P!0.0001). The proportion of llamas that ovulated in response to equine and porcine seminal plasma was intermediate. We conclude that the mechanism for the biological response to OIF is present in prepubertal CD-1 mice and that OIF is present in equine and porcine seminal plasma.

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Coital and Estrogen Signals: A Contrast in the Preovulatory Neuroendocrine Networks of Rabbits and Rhesus Monkeys1

Cited by 45 publications

References 139 publications

Regeneration of Uterine Horn Using Porcine Small Intestinal Submucosa Grafts in Rabbits

Regeneration of Uterine Horn Using Porcine Small Intestinal Submucosa Grafts in Rabbits

Neuroendocrine Regulation of GnRH Release in Induced Ovulators

Evidence for the conservation of biological activity of ovulation-inducing factor in seminal plasma

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