Cola Beverage Consumption Induces Bone Mineralization Reduction in Ovariectomized Rats

García-Contreras, F; Paniagua, Ramón; Ávila-Díaz, Marcela; Cabrera-Muñoz, Lourdes; Martínez-Muñiz, Irma; Foyo-Niembro, Enrique; Amato, Dante

doi:10.1016/s0188-4409(00)00090-4

Cited by 43 publications

(52 citation statements)

References 19 publications

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“…7 In agreement with these earlier reports, pair-fed rats consuming tap water did not develop signs of bone disorder (hypocalcemia and reduced femoral mineralization) which were observed in rats that ingested high levels of cola drinks. 9 The association between bone metabolism disorders and cola beverage intake has also been attributed to some components of the cola beverage formulation, some of which is confidential with regard to constituents and quantities: the exact composition of the cola beverage syrup is an industrial trade secret.…”

Section: Discussionmentioning

confidence: 99%

“…9,15 Furthermore, cola beverages are rich in caffeine, which has been associated with reduced bone mineral density and increased fracture risk. 16,17 According to Kinney 18 (2002), non-cola carbonated soft drinks, which do not contain phosphoric acid or caffeine, have not been associated with fracture risk among Graph 1 -Neoformed bone trabeculae (%) (mean ± SEM) in the alveolar apical third of rats from the control and cola groups at two and three weeks after tooth extraction (one way ANOVA followed by Tukey's multiple comparison test, *statistically significant difference between the cola group and respective control, p < 0.01).…”

Section: Discussionmentioning

confidence: 99%

“…7 It is known that acidifying dietary constituents may also negatively affect calcium metabolism and accelerate bone resorption. 19 Thus, another possible mechanism underlying the effect on bone metabolism may be the acid load characteristic of cola drinks, which may adversely affect calcium and bone metabolism by increasing bone resorption and calcium mobilization and reducing the renal production of 25-hydroxy-vitamin-D. 9 …”

Section: Discussionmentioning

confidence: 99%

“…Investigations carried out in humans 7 and in animal models 9 confirm that different bones respond in a distinct manner when exposed to adverse conditions, including cola beverage intake. To the best of our knowledge, none of the epidemiological or experimental studies to date have reported the effect of cola beverage consumption on alveolar bone, a bone region of major interest in dentistry.…”

Section: Introductionmentioning

confidence: 93%

“…Acute ingestion of cola drinks for seven days causes plasma and urinary signs of disrupted calcium and phosphate metabolism, which are more severe in immature (30-day-old) than in adult (90-day-old) rats. 8 Diminished femoral mineralization was observed in ovariectomized rats 9 and in normal male and female rats 10 submitted to prolonged ingestion of cola beverages.…”

Section: Introductionmentioning

confidence: 96%

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Cola beverage consumption delays alveolar bone healing: a histometric study in rats

2010

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Epidemiological studies have suggested that cola beverage consumption may affect bone metabolism and increase bone fracture risk. Experimental evidence linking cola beverage consumption to deleterious effects on bone is lacking. Herein, we investigated whether cola beverage consumption from weaning to early puberty delays the rate of reparative bone formation inside the socket of an extracted tooth in rats. Twenty male Wistar rats received cola beverage (cola group) or tap water (control group) ad libitum from the age of 23 days until tooth extraction at 42 days and euthanasia 2 and 3 weeks later. The neoformed bone volume inside the alveolar socket was estimated in semi-serial longitudinal sections using a quantitative differential point-counting method. Histological examination suggested a decrease in the osteogenic process within the tooth sockets of rats from both cola groups, which had thinner and sparser new bone trabeculae. Histometric data confirmed that alveolar bone healing was significantly delayed in cola-fed rats at three weeks after tooth extraction (ANOVA, p = 0.0006, followed by Tukey's test, p < 0.01). Although the results of studies in rats cannot be extrapolated directly to human clinical dentistry, the present study provides evidence that cola beverage consumption negatively affect maxillary bone formation.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 96%

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Cola beverage consumption delays alveolar bone healing: a histometric study in rats

2010

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Serum Phosphate Is Associated With Fracture Risk: The Rotterdam Study and MrOS

Campos‐Obando

Koek

Hooker

et al. 2017

J of Bone & Mineral Res

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Extreme phosphate levels (P) have been associated with mineralization defects and increased fracture risk. Whether P within normal range is related to bone health in the general population is not well understood. To investigate the association of P with bone mineral density (BMD) and fracture risk, we assessed two population-based cohorts: the Dutch Rotterdam Study (RS-I, RS-II, RS-III; n=6791) and the US Osteoporotic Fractures in Men (MrOS; n=5425) study. The relationship of P with lumbar spine (LS) and femoral neck (FN) BMD was tested in all cohorts via linear models; fracture risk was tested in RS-I, RS-II and MrOS through Cox models, after follow-up of 8.6, 6.6 and 10.9 years, respectively. Adjustments were made for age, body mass index, smoking, serum levels of calcium, potassium, 25-hydroxyvitamin D, and estimated glomerular filtration rate (eGFR), FN-BMD, prevalent diabetes and cardiovascular disease. Additional adjustments were made for phosphate intake, parathyroid hormone, and fibroblast growth factor 23 levels in MrOS. We further stratified by eGFR. Results were pooled through study-level meta-analyses. Hazard ratios (HR) and betas (β) (from meta-analyses) are expressed per 1 mg/dL P increase. P was positively associated with fracture risk in men and women from RS and findings were replicated in MrOS (pooled HR all (95% CI): 1.47 (1.31–1.65)). P was associated with fracture risk in subjects without chronic kidney disease (CKD): all (1.44 (1.26–1.63)) and in men with CKD (1.93 (1.42–2.62)). P was inversely related to LS-BMD in men (β: −0.06 (−0.11 to −0.02)) and not to FN-BMD in either sex. In summary, serum P was positively related to fracture risk independently from BMD and phosphate intake after adjustments for potential confounders. P and LS-BMD were negatively related in men. Our findings suggest that increased P levels even within normal range might be deleterious for bone health in the normal population.

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