Colangiocarcinoma Em Cão Com Metástase Em Omento, Linfonodos Regionais E Pâncreas – Relato De Caso

Gusmão, Marco Aurélio; Keller, Daniel F.; Filho, Almir Alves dos Santos; Torres, Márcia Bersane Araújo de Medeiros

doi:10.25110/arqvet.v18i2.2015.5384

Cited by 1 publication

(4 citation statements)

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“…Biliary duct carcinomas are firm, elevated, non--encapsulated, have a central umbilicated-like depression, and multiple whitish nodules [1,2,[5][6][7], similar to that observed in cat 1. Evaluation of cat 2 revealed tumors with the same consistency, but presented as masses of large sizes, covering almost all the hepatic parenchyma.…”

Section: Discussionmentioning

confidence: 75%

“…Among other predisposing factors of cholangiocellular carcinoma are the chemical agents plutonium and americium, intestinal parasites such as Ancylostoma spp. and Trichuris vulpis, and the presence of chronic inflammation independent of the etiology, as long as they cause exacerbated proliferation of biliary duct epithelium cells [7,13].…”

Section: Discussionmentioning

confidence: 99%

“…Cholangiocarcinoma are malignant neoplasms that primarily originate from the intrahepatic or extrahepatic areas or gallbladder. This tumor type, although widely reported in animal species such as canines, felines, cattle, horses, sheep, and goats, occurs mainly in senior dogs and cats [7]. Primary hepatobiliary tumors are considered rare in cats, with prevalence ranging from 1.5% to 2.3% among neoplasms in felines.…”

Section: Introductionmentioning

confidence: 99%

“…The clinical signs of injury are considered non-specific, and the causes of cholangiocarcinoma are not defined in domestic animals. Some risk factors are predisposing, such as bile and intestinal parasitosis, exposure to chemical agents, and chronic inflammation [6,7]. Cholangiocellular carcinomas are considered intractable due to the potential of dissemination, migration, and progression.…”

Section: Introductionmentioning

confidence: 99%

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Cholangiocarcinoma in Young Cats

Jardim

Cid

Oliveira

et al. 2019

Acta Scientiae. Vet.

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Background: Cholangiocellular carcinoma is a malignant tumor that occurs mainly in elderly dogs and cats. Primary hepatobiliary neoplasms are considered rare in felines, although cholangiocarcinoma is the most common tumor type among malignant liver tumors in the species. The objective of this work is to report two cases of cholangiocarcinoma in young domestic cats, with three years old, and to approach clinical and pathological aspects to promote awareness of this type of injury in young animals, with a focus on prevention of predisposing factors. Cases: A 3-year-old male domestic cat (cat 1) had a history of progressive weight loss, persistent vomiting, diarrhea, and episodes of seizure. At the clinical examination was noted moderate degree of jaundice. In the biochemical exams it was verified as alteration hypoproteinemia, increase of urea and hyponatremia. Abdominal ultrasonography revealed a formation in the left epigastric region measuring 8.0 x 5.0 cm, with a diffusely heterogeneous parenchyma, suggestive of hepatic neoplasia, in addition to the presence of free abdominal fluid. Cavity fluid analysis was suggestive of carcinoma. A 3-year-old male domestic cat (cat 2), with history of hyporexia, emaciation and vomiting was taken to care. Physical examination showed moderate dehydration, hypocorous mucosa and presence of abdominal mass on palpation. The animal's serum biochemical assessment were verified as changes, increasing AST. Ultrasonographic examination showed an abdominal mass, located caudally to the spleen, with irregular shape, measuring approximately 4.7 cm suggestive of hepatic neoplasia, in addition to the presence of abdominal fluid. The hepatic cytology performed by fine needle aspiration was suggestive of carcinoma. After the clinical worsening of two cats and due unfavorable prognosis, euthanasia and necropsy were performed. In the macroscopic analysis of cat 1, numerous nodules of whitish and sometimes "umbilicate" coloration were observed in the liver, measuring up to three cm in diameter, distributed randomly by the hepatic parenchyma and with a soft consistency at cut. An ovoid-wicking mass, measuring 6.0 x 7.0 x 5.0 cm and coloring ranging from white to light brown was checked in omentum. In the macroscopic evaluation of cat 2, numerous coalescing masses of whitish coloring measuring up to 6.0 cm in diameter were observed covering almost every hepatic parenchyma and also affecting the pancreas, with a soft consistency at cut. The microscopic findings of both cats were compatible with the diagnosis of cholangiocarcinoma. Considering the immunohistochemical profile, in both cases there was positivity for the CK Pan antibody and CEA and negativity for the CK20, TTF-1, Hepatocyte specific antigen, CD10 and CD56 antibodies. Discussion: Cholangiocarcinomas usually occur in elderly animals, with a mean age of 9 years, so it may be suggested that the cause of the disease in cat 1 and 2 was possibly related to the early and continuous presence of carcinogens. The biliary duct trematod Platynoso...

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Section: Discussionmentioning

confidence: 75%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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