Colchicine-induced alterations of reference memory in rats: role of spatial versus non-spatial task components

Nanry, Kevin P.; Mundy, William R.; Tilson, Hugh A.

doi:10.1016/s0166-4328(89)80007-5

Cited by 54 publications

(31 citation statements)

References 24 publications

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“…Colchicine has been used extensively to destroy dentate gyrus granule cells but not pyramidal cells due to its selectivity for a particular isomer of tubulin, which is found on granule-cell somas but not on the somas of pyramidal neurons (Mundy and Tilson, 1990). In addition to the present study, multiple studies have demonstrated that intracranial infusions of colchicine result in significant cell loss in the dentate gyrus, with little or no cell loss in the CA fields (Emerich and Walsh, 1989;Mundy and Tilson, 1990;Narny et al, 1989;Walsh et al, 1986). With a toxin such as ibotenic acid, it would be very difficult, if not impossible, to lesion only the dentate gyrus without causing damage to CA3/4 due to its proximity to the dentate gyrus.…”

Section: Neurotoxin Surgerymentioning

confidence: 48%

“…See below, "Three-Dimensional Reconstruction and Volumetry," and Figures 6 and 7 for a quantitative analysis of the damage to each hippocampal subregion following DG and CA1 lesions. Prior experiments have also shown similar lesion selectivity within hippocampus (Emerich and Walsh, 1989;Mundy and Tilson, 1990;Narny et al, 1989;Walsh et al, 1986). Other studies have also demonstrated highly selective DG lesions with minimal CA field damage following long-term adrenalectomy (Conrad and Roy, 1993).…”

Section: Histologymentioning

confidence: 77%

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Dissociating hippocampal subregions: A double dissociation between dentate gyrus and CA1

2001

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This study presents a double dissociation between the dentate gyrus (DG) and CA1. Rats with either DG or CA1 lesions were tested on tasks requiring either spatial or spatial temporal order pattern separation. To assess spatial pattern separation, rats were trained to displace an object which covered a baited food-well. The rats were then allowed to choose between two identical objects: one covered the same well as the sample phase object (correct choice), and a second object covered a different unbaited well (incorrect choice). Spatial separations of 15-105 cm were used to separate the correct object from the incorrect object. To assess spatial temporal order pattern separation, rats were allowed to visit each arm of a radial eight-arm maze once in a randomly determined sequence. The rats were then presented with two arms and were required to choose the arm which occurred earliest in the sequence. The choice arms varied according to temporal separation (0, 2, 4, or 6) or the number of arms that occurred between the two choice arms in the sample phase sequence. On each task, once a preoperative criterion was reached, each rat was given either a DG, CA1, or control lesion and then retested. The results demonstrated that DG lesions resulted in a deficit on the spatial task but not the temporal task. In contrast, CA1 lesions resulted in a deficit on the temporal task but not the spatial task. Results suggest that the DG supports spatial pattern separation, whereas CA1 supports temporal pattern separation.

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Section: Neurotoxin Surgerymentioning

confidence: 48%

Section: Histologymentioning

confidence: 77%

Dissociating hippocampal subregions: A double dissociation between dentate gyrus and CA1

2001

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“…Numerous early and recent studies demonstrated that a flat retrograde amnesia was induced by lesions of dHC and the entire HC at 0.5-3.5 months in watermaze memory retention (Bolhuis et al, 1994;Mumby et al, 1999; logical changes found in CA3 stratum oriens (Ramirez-Amaya et al, 2001) and may indicate involvement of the CA3 autoassociative network in recent (Nakazawa et al, 2002(Nakazawa et al, , 2003Meilandt et al, 2004) as well as in long-term memory storage and recall. Mapping data support the idea that DG is not only involved in memory encoding but also participates in memory retrieval (Nanry et al, 1989;Lisman, 1999). The enduring disinhibition of CA1 pyramidal cells found in slices of recently WMT rats may represent transient information storage in CA1 (Gusev and Alkon, 2001).…”

Section: Discussionmentioning

confidence: 66%

Topography of Arc/Arg3.1 mRNA Expression in the Dorsal and Ventral Hippocampus Induced by Recent and Remote Spatial Memory Recall: Dissociation of CA3 and CA1 Activation

Gusev¹,

Cui²,

Alkon³

et al. 2005

J. Neurosci.

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The understanding of the mechanisms of memory retrieval and its deficits, and the detection of memory underlying neuronal plasticity, is greatly impeded by a lack of precise knowledge of the brain circuitry that underlies the functions of memory. The specific roles of anatomically distinct hippocampal subdivisions in recent and long-term memory retention and recall are essentially unknown. To address these questions, we mapped the expression of Arc/Arg 3.1 mRNA, a neuronal activity marker, in memory retention at multiple rostrocaudal levels of the dentate gyrus, CA3, CA1, subiculum, and lateral and medial entorhinal cortices after a platform search in a water-maze spatial task at 24 h and 1 month compared with swim and naive controls. We found that the entorhinohippocampal neuronal activity underlying the recall of recent and remote spatial memory has an anatomically distributed and time-dependent organization throughout both the dorsal and ventral hippocampus that is subdivision specific. We found a dissociation in the activity of the entorhinal cortex, CA3, and CA1 over a period of memory consolidation. Although CA3, the dorsal hippocampus, and the entorhinal cortex demonstrated the most persistent learning-specific signal during both recent and long-term memory recall, CA1 and the ventral hippocampus displayed the most dramatic signal decline. We determined the coordinates of activity clusters in the hippocampal subdivisions during the platform search and their dynamics over time. Our mapping data suggest that although the level of corticohippocampal interaction is similar during the retrieval of recent and remote spatial memories, the mnemonic function of the hippocampus may have changed, and the activity underlying remote spatial memory could be anatomically segregated within hippocampal subdivisions in small segments.

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“…These results could indicate that the CA3, but not the DG, subregion is involved in associative learning. Furthermore, DG, but not CA3, lesioned rats produce a deficit in the acquisition of the standard version water maze (Sutherland et al 1983;Nanry et al 1989;Xavier et al 1999;Lassalle et al 2000).…”

mentioning

confidence: 92%

Disconnection analysis of CA3 and DG in mediating encoding but not retrieval in a spatial maze learning task

Jerman¹,

Kesner²,

Hunsaker³

2006

Learn. Mem.

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The dentate gyrus (DG) subregion of the hippocampus has been shown to be involved in encoding but not retrieval in a spatial maze task (modified Hebb-Williams maze). The first experiment in this study examined whether a lesion to the CA3 would contribute to a similar encoding deficit. A DG group was included in order to replicate previous results. Relative to controls, animals receiving CA3 lesions were impaired in encoding, not retrieval, on the modified Hebb-Williams maze-similar to a group that received DG lesions. This suggests the possibility that CA3 and DG are working together to mediate encoding processes. The second experiment in this study was designed to test the interaction between CA3 and DG using a disconnection paradigm. Animals with contralateral lesions (CA3 lesioned in one hemisphere, DG lesioned in the other hemisphere) showed a significant disruption effect on encoding, but not retrieval, when compared with animals with ipsilateral lesions (CA3 and DG lesioned in the same hemisphere, leaving the other hemisphere intact). This suggests an interaction between CA3 and DG in supporting encoding but not retrieval processes in a spatial maze learning task.

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Colchicine-induced alterations of reference memory in rats: role of spatial versus non-spatial task components

Cited by 54 publications

References 24 publications

Dissociating hippocampal subregions: A double dissociation between dentate gyrus and CA1

Dissociating hippocampal subregions: A double dissociation between dentate gyrus and CA1

Topography of Arc/Arg3.1 mRNA Expression in the Dorsal and Ventral Hippocampus Induced by Recent and Remote Spatial Memory Recall: Dissociation of CA3 and CA1 Activation

Disconnection analysis of CA3 and DG in mediating encoding but not retrieval in a spatial maze learning task

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