Cold-adaptation: Neuropeptide Y versus thermal signals in the development of hyperphagia

Balaskó, Márta; Pétervári, Erika; Koncsecskó-Gáspár, M.; Székely, Miklós

doi:10.1016/j.jtherbio.2005.12.002

Cited by 2 publications

(2 citation statements)

References 31 publications

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“…NPY and AgRP expressions were increased to increase appetite and reduce heat production. POMC and CART expressions were reduced, which also increased appetite (Balaskó et al, 2006;Larsen and Hunter, 2006;Kim and Harrington, 2008;Tracy et al, 2008;Lukaszewski et al, 2013;Zhao et al, 2014). These results indicated that NPY/AgRP and POMC/CART expressions can regulate body mass and energy metabolism in A. chevrieri under conditions of FD.…”

Section: Serum Leptin Level and Hypothalamic Neuropeptide Gene Expresmentioning

confidence: 70%

Effects of random food deprivation and refeeding on energy metabolism, behavior and hypothalamic neuropeptide expression in Apodemus chevrieri

Zhu¹,

Wang²

2016

Comparative Biochemistry and Physiology Part A: Molecular &

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Maintaining adaptive control of behavior and physiology is the main strategy used by animals in responding to changes of food resources. To investigate the effects of random food deprivation (FD) and refeeding on energy metabolism and behavior in Apodemus chevrieri, we acclimated adult males to FD for 4weeks, then refed them ad libitum for 4weeks (FD-Re group). During the period of FD, animals were fed ad libitum for 4 randomly assigned days each week, and deprived of food the other 3days. A control group was fed ad libitum for 8weeks. At 4 and 8weeks we measured body mass, thermogenesis, serum leptin levels, body composition, gastrointestinal tract morphology, behavior and hypothalamic neuropeptide expression. At 4weeks, food intake, gastrointestinal mass, neuropeptide Y (NPY) and agouti-related protein (AgRP) mRNA expressions increased and thermogenesis, leptin levels, pro-opiomelanocortin (POMC) and cocaine- and amphetamine-regulated transcript (CART) expressions decreased in FD compared with controls. FD also showed more resting behavior and less activity than the controls on ad libitum day. There were no differences between FD-Re and controls at 8weeks, indicating significant plasticity. These results suggested that animals can compensate for unpredictable reduction in food availability by increasing food intake and reducing energy expended through thermogenesis and activity. Leptin levels, NPY, AgRP, POMC, and CART mRNA levels may also regulate energy metabolism. Significant plasticity in energy metabolism and behavior was shown by A. chevrieri over a short timescale, allowing them to adapt to food shortages in nutritionally unpredictable environments.

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Section: Serum Leptin Level and Hypothalamic Neuropeptide Gene Expresmentioning

confidence: 70%

Effects of random food deprivation and refeeding on energy metabolism, behavior and hypothalamic neuropeptide expression in Apodemus chevrieri

Zhu¹,

Wang²

2016

Comparative Biochemistry and Physiology Part A: Molecular &

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“…An increased sensitivity for orexigenic peptides could be supported by the finding that NPY antagonists caused greater reduction of hyperphagia induced by NPY-injection in cold-adapted than in non-adapted rats. However, this conclusion is not supported by the finding that the same antagonists influenced the refeeding hyperphagia only in non-adapted, but not in cold-adapted rats, despite that they reversed the fasting hypothermia in both groups (380). Apparently, an elevated orexigenic tone developing with cold adaptation cannot be explained simply by a higher NPY activity.…”

Section: Duringmentioning

confidence: 83%

Thermoregulation energy balance regulatory peptides recent developments

Székely

Pétervári

Balaskó³

2010

Front Biosci

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Energy balance of the body is determined mainly by the function of various hypothalamic and brainstem nuclei, according to a complex interaction between the regulation of body temperature (actual metabolic rate vs. heat loss) and regulation of body weight (metabolic rate vs. food intake). The direct effect of central anabolic neuropeptides (neuropeptide Y, orexins, melanin concentrating hormone, etc.) is to enhance food intake and suppress metabolic rate with a tendency to cause hypothermia, while central catabolic neuropeptides (melanocortins, corticotropin releasing factor, cocaine-amphetamine regulated peptide, etc.) suppress food intake and enhance energy expenditure with a tendency to induce hyperthermia. Many other neuropeptides are neither clearly anabolic, nor clearly catabolic, but still influence these complex hypothalamic/brainstem functions. Some peripheral peptides (e.g. leptin, insulin, ghrelin) acting at either peripheral or cerebral sites also contribute to the regulation of energy balance. The prevailing thermoregulatory status, the substances or neural signals representing actual feeding vs. established nutritional states, and the aging process may modify the expression and/or activity of peripheral and central peptides and peptide receptors.

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Cold-adaptation: Neuropeptide Y versus thermal signals in the development of hyperphagia

Cited by 2 publications

References 31 publications

Effects of random food deprivation and refeeding on energy metabolism, behavior and hypothalamic neuropeptide expression in Apodemus chevrieri

Effects of random food deprivation and refeeding on energy metabolism, behavior and hypothalamic neuropeptide expression in Apodemus chevrieri

Thermoregulation energy balance regulatory peptides recent developments

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