Cold atmospheric pressure plasma for attenuation of SARS-CoV-2 spike protein binding to ACE2 protein and the RNA deactivation

Abstract

Cold atmospheric pressure (CAP) plasma for the deactivation of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) spike protein binding to ACE2 protein.

Energy Conservation Optimization and Numerical Simulation of Urban Green Space Landscape Pattern

“…e interaction between the planning scheme and wind speed, temperature, and SO 2 concentration was explored, the urban green space layout and functional division were determined and guided according to the evaluation results, and the rationality of the green space layout of the scheme was evaluated. In the planning, the optimization measures and conceptual design of urban green space system planning can be simulated and evaluated, so as to provide a certain reference for the optimization of urban green space landscape pattern [12].…”

Cold atmospheric plasma driven self-assembly in serum proteins: insights into the protein aggregation to biomaterials

“…The gas temperature was estimated by comparing the experimental spectrum with a theoretically simulated spectrum provided by software like LIFBASE 49 and SPECAIR, 50 as described in our previous publications. 26,51 The temperature of the plasma jet array was found to be ∼310 K in the plasma region. As a result of this low plasma temperature, the sample also remained at room temperature after plasma treatment.…”

“…Reactive oxygen/nitrogen species are an integral part of the CAP and interact with the proteins, causing further reactions in the solution. To elucidate the protein self-assembly due to CAP treatment, we studied the different ROS/RNS associated with the CAP treatment using the protocols mentioned in the literature 26 and given in Table 2 .…”

“…The four-jet structure helped us achieve a higher plasma dose than the single jet plasma used in our earlier works for the same treatment time. 26,51 It consisted of four dielectric tubes made of glass with an inner diameter of 5 mm and an outer diameter of 7 mm tted into a Teon housing with a gas inlet, as shown in the gure. On the outer surface of the glass tubes, aluminium strips of width 7 mm were wrapped around near the end and connected together, which served as the powered electrode.…”

“…[15][16][17] Various research studies use non thermal CAP in biological materials, including cell permeabilization, chronic wound disinfection and healing, decontamination of surfaces, dental applications, [18][19][20][21] and the destruction of bacteria, fungi spores and viruses has been reported in the literature. [22][23][24][25][26] In Germany, CAP has been used in trial therapy for head and neck cancer patients. 27,28 Low temperature plasmas have the ability to kill cancer cells without harming healthy ones, leading to the eld of plasma oncology.…”