Cold Atmospheric Pressure Plasma Jet Reduces Trichophyton rubrum Adherence and Infection Capacity

Borges, Aline Chiodi; Nishime, Thalita Mayumi Castaldelli; Rovetta, Sabrina de Moura; Lima, Gabriela de Morais Gouvêa; Kostov, K. G.; Thim, Gilmar Patrocínio; Menezes, Beatriz Rossi Canuto de; Machado, João Paulo Barros; Koga‐Ito, Cristiane Yumi

doi:10.1007/s11046-019-00375-2

Cited by 12 publications

(18 citation statements)

References 38 publications

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“…Not surprisingly, similarly to topical anti‐fungal treatment, 22 superficial white onychomycosis was more amenable to treatment than subungual onychomycosis. Whereas previous studies have shown the efficacy of cold atmospheric plasma for onychomycosis, 7‐9 this study has demonstrated that cold sub‐atmospheric pressure plasma produces a superior nail fungi growth reduction. To the best of our knowledge, this is the first study to test the applicability of low pressure plasma for onychomycosis as well as for T. rubrum .…”

Section: Discussioncontrasting

confidence: 56%

“…5,6 Limited data, mainly based on in-vitro infected nail models, suggests that the use of cold atmospheric plasma (CAPP) devices for onychomycosis is beneficial for nails infected with T. rubrum, T. mentagrophytes as well as Candida albicans. [7][8][9] A comprehensive study held by Borges et al has shown that CAPP inhibits T. rubrum nail growth, adherence and infection capacity. 7 A pilot study of 13 patients has reported that CAPP is safe and well tolerated.…”

Section: Introductionmentioning

confidence: 99%

“…[7][8][9] A comprehensive study held by Borges et al has shown that CAPP inhibits T. rubrum nail growth, adherence and infection capacity. 7 A pilot study of 13 patients has reported that CAPP is safe and well tolerated. 10 The overall clinical cure was 53.8% and the mycological cure was 15.4%, which is considerably higher than topical anti-fungal treatment.…”

Section: Introductionmentioning

confidence: 99%

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Cold sub‐atmospheric and atmospheric pressure plasma for the treatment of Trichophyton rubrum onychomycosis: An in‐vitro study

Shemer

Daniel

Kassem

et al. 2020

Dermatologic Therapy

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Previous studies have suggested the applicability of cold atmospheric pressure plasma for the treatment of onychomycosis. Whether delivering cold plasma in subatmospheric pressure would be beneficial for this purpose is yet to be established. The current study aimed to evaluate efficacy of cold sub-atmospheric and atmospheric pressure plasma in Trichophyton rubrum growth inhibition. Bovine nails infected with T. rubrum were treated by a cold air plasma device, which enables utilizing plasma in sub-atmospheric pressures (Low = 100 millibar; High = 300 millibar) or atmospheric pressure. The infected foci were exposed to the plasma source directly or indirectly. Treatment with high sub-atmospheric pressure setting achieved T. rubrum growth reduction of 94.0% and 73.0%, for direct and indirect exposure to the plasma source, respectively (P < .001). Low sub-atmospheric pressure setting achieved similar T. rubrum growth reduction of 86.2% for direct exposure to the plasma source (P < .001), but only marginally significant 58.8% reduction rate for indirect exposure to the plasma source (P = .056). None statistically significant fungal growth reduction was attained with the use of atmospheric pressure setting. Cold plasma was shown to effectively inhibit T. rubrum nail growth, with sub-atmospheric pressure setting achieving better outcome than atmospheric pressure.

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Section: Discussioncontrasting

confidence: 56%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Cold sub‐atmospheric and atmospheric pressure plasma for the treatment of Trichophyton rubrum onychomycosis: An in‐vitro study

Shemer

Daniel

Kassem

et al. 2020

Dermatologic Therapy

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“…An in vitro study using surface microdischarge plasma achieved fungal growth inhibition in Trichophyton rubrum and Microsporum canis but only when daily 10‐minute long treatments were used for 9 days 81 . Another ex vivo nail infection model based study used helium jet plasma to successfully inhibit Trichophyton rubrum adhesion, germination, and growth in vitro 82 . The first clinical pilot used DBD plasma on toenails.…”

Section: Clinical Cold Plasma Applications In Dermatologymentioning

confidence: 99%

Cold atmospheric pressure (physical) plasma in dermatology: where are we today?

Friedman

2020

Int J Dermatology

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Cold atmospheric pressure plasma is physical plasma (essentially ionized gas) created at room temperature and atmospheric pressure, and it has complex effects on cells, tissues, and living organisms. These effects are studied extensively for medical and dermatological use. This article reviews current achievements and new trends in clinical dermatological cold plasma research, discusses the basics of plasma physics and plasma engineering, and describes the most important areas of laboratory plasma research to provide a wellrounded understanding of the nature, present applications, and future promise of this exciting, emerging technology.

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“…The mechanisms of fungal spores inactivation by ROS produced by the non-equilibrium atmospheric-pressure plasma were carefully studied by Ito et al [17]. Inter alia, Ali et al [18] or Borges et al [19] have described the in vitro inactivation of Trichophyton spp. Bulson et al [20] described the same effects applied on dermatomycosis treatment on in vitro human nail model.…”

Section: Introductionmentioning

confidence: 99%

Inactivation of Dermatophytes Causing Onychomycosis Using Non-Thermal Plasma as a Prerequisite for Therapy

Lokajová

Julák

Khun

et al. 2021

JoF

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Following our previous study of the therapy of onychomycosis by non-thermal plasma (NTP) and nail hygiene and to obtain some prerequisite data of dermatophytes sensitivity, the dynamics of those inactivation by NTP plasma was monitored for various strains of Trichophyton iterdigitale, Trichophyton benhamiae, Trichophyton rubrum, and Microsporum canis. Three strains of each species on agar plates were exposed with plasma produced by a DC corona discharge in the point-to-ring arrangement in various time intervals. Although all strains were sufficiently sensitive to plasma action, significant differences were observed in their sensitivity and inactivation dynamics. These differences did not correlate with the species classification of individual strains, but could be assigned to four arbitrarily created types of strain response to NTP according to their sensitivity. These results indicate that the sensitivity to plasma is not an inherent property of the fungal species, but varies from strain to strain.

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Cold Atmospheric Pressure Plasma Jet Reduces Trichophyton rubrum Adherence and Infection Capacity

Cited by 12 publications

References 38 publications

Cold sub‐atmospheric and atmospheric pressure plasma for the treatment of Trichophyton rubrum onychomycosis: An in‐vitro study

Cold sub‐atmospheric and atmospheric pressure plasma for the treatment of Trichophyton rubrum onychomycosis: An in‐vitro study

Cold atmospheric pressure (physical) plasma in dermatology: where are we today?

Inactivation of Dermatophytes Causing Onychomycosis Using Non-Thermal Plasma as a Prerequisite for Therapy

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