Cold Haemagglutinins: Unusual Incidence in Melanesian Populations

Curtain, C. C.; Baumgarten, A.; Gorman, J.M.; Kidson, Chev; Champness, L. T.; Rodrigue, R.; Gajdusek, D. Carleton

doi:10.1111/j.1365-2141.1965.tb06610.x

Cited by 38 publications

(14 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It has been suggested that the high incidence of cold agglutinins found in groups living in a tropical environment is due partly to parasitic infections, especially malaria (Curtain et al, 1965). The CAST (Garrow, 1958) was quick and simple.…”

Section: Cold Agglutininsmentioning

confidence: 94%

Mycoplasma pneumoniae and the aetiology of lobar pneumonia in Northern Nigeria

1980

Journal of Infection

View full text Add to dashboard Cite

Over a six-month period we studied 74 adult Nigerians who presented consecutively to Ahmadu Bello University Teaching Hospital, Zaria, with lobar or segmental pneumonia. Pneumococcal infection was diagnosed in 50% by the detection of pneumococcal polysaccharide antigen in serum or purulent sputum: 24% had pneumococcal antigenaemia. Twelve patients had evidence of Mycoplasma pneumoniae infection and half of these also had pneumococcal infection. The suggestion that M pneumoniae respiratory infection may predispose to serious bacterial pneumonia is discussed. The initial clinical and radiological features were similar in the pneumococcal and M pneumoniae groups. Raised cold agglutinin titres were not a reliable indication of M pneumoniae infection, perhaps due to altered autoantibody production in Nigerians. Pneumonia was commoner in the dry season, probably related to depressed nasopharyngeal defences caused by drying. Less common causes of lobar pneumonia that were found are also discussed and no cases of legionnaires' disease were identified.

show abstract

Section: Cold Agglutininsmentioning

confidence: 94%

Mycoplasma pneumoniae and the aetiology of lobar pneumonia in Northern Nigeria

1980

Journal of Infection

View full text Add to dashboard Cite

show abstract

“…Booth, Jenkins and Marsh [3] found a high incidence of cold antibody directed against an antigen on human foetal cells, which they called IT. Curtain et al [7] found single sera with cold agglutinins which agglutinated I-positive, I-negative and foetal cells amongst the Tolai people of the Gazelle Peninsula of New Britain and Booth [2] reported cold anti-P in indigenous blood donors in the Port Moresby district.…”

Section: Discussionmentioning

confidence: 99%

A High Frequency of Cold Agglutinins of Anti-IA Specificity in a New Guinea Highland Population

Baumgarten

Curtain²

1970

Vox Sanguinis

Self Cite

View full text Add to dashboard Cite

A high incidence (37 out of 188) of anti-IA cold agglutinins was found in the sera of indigenous New Guineans living at Minj (alt. 1,600—1,800 m) in the Western Highlands District of New Guinea. Anti-IA did not occur in three other populations tested, although these possessed a high incidence of anti-I antibodies. The earlier findings concerning the incidence of specificity of cold haemagglutinins in New Guinea are reviewed and it is suggested that they may be induced by different agents, probably of a parasitic nature, in different localities. It is predicted that cold agglutinins should be found in other populations which are subject to high rates of infection similar to those in New Guinea.

show abstract

“…Cold haemagglutinins are observed frequently in serum samples from certain population groups in Melanesia, especially from the Tolais in New Britain [2,3,5], It has been suggested that they are produced by a random process during the intense globulin synthesis which occurs in individuals subject to malaria and other tropical infections [5]. Cold agglutinins have not been demonstrated in cord blood, but their frequency approaches that in adults by the time the children reach the age of 12 years [3].…”

mentioning

confidence: 99%

Cold Haemagglutinins Associated with Splenomegaly in New Guinea

Pitney¹,

Thomas²,

Wells³

1968

Vox Sanguinis

View full text Add to dashboard Cite

A high incidence of cold haemagglutinins with anti-i specificity was found in serum samples from patients with massive splenomegaly of uncertain cause in the Watut valley of New Guinea. The samples contained increased concentrations of macroglobulin, 16—33% of which represented cold agglutinin activity. Tropical splenomegaly constitutes another condition in which anti-i appears in association with hyperplasia of reticulo-endothelial tissue.

show abstract

Cold Haemagglutinins: Unusual Incidence in Melanesian Populations

Cited by 38 publications

References 26 publications

Mycoplasma pneumoniae and the aetiology of lobar pneumonia in Northern Nigeria

Mycoplasma pneumoniae and the aetiology of lobar pneumonia in Northern Nigeria

A High Frequency of Cold Agglutinins of Anti-IA Specificity in a New Guinea Highland Population

Cold Haemagglutinins Associated with Splenomegaly in New Guinea

Contact Info

Product

Resources

About