Cole-Cole analysis of thrombus formation in an extracorporeal blood flow circulation using electrical measurement

Huu, Dung Nguyen; Kikuchi, Daisuke; Maruyama, Osamu; Sapkota, Achyut; Takei, Masahiro

doi:10.1016/j.flowmeasinst.2016.06.025

Cited by 17 publications

(4 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Recent studies have utilized the Cole-impedance model in biologic applications including: Characterizing the electrical impedance of blood for potential monitoring of thrombus formation [11], predicting myofiber size in mice [12], modeling the electrical impedance of botanical elements [13]. While this is not an exhaustive list, it does highlight the varied applications of the Cole-impedance model in biology.…”

Section: Introductionmentioning

confidence: 99%

Fatigue-Induced Cole Electrical Impedance Model Changes of Biceps Tissue Bioimpedance

Freeborn

2018

Fractal Fract

View full text Add to dashboard Cite

Bioimpedance, or the electrical impedance of biological tissues, describes the passive electrical properties of these materials. To simplify bioimpedance datasets, fractional-order equivalent circuit presentations are often used, with the Cole-impedance model being one of the most widely used fractional-order circuits for this purpose. In this work, bioimpedance measurements from 10 kHz to 100 kHz were collected from participants biceps tissues immediately prior and immediately post completion of a fatiguing exercise protocol. The Cole-impedance parameters that best fit these datasets were determined using numerical optimization procedures, with relative errors of within approximately ± 0.5 % and ± 2 % for the simulated resistance and reactance compared to the experimental data. Comparison between the pre and post fatigue Cole-impedance parameters shows that the R ∞ , R 1 , and f p components exhibited statistically significant mean differences as a result of the fatigue induced changes in the study participants.

show abstract

Section: Introductionmentioning

confidence: 99%

Fatigue-Induced Cole Electrical Impedance Model Changes of Biceps Tissue Bioimpedance

Freeborn

2018

Fractal Fract

View full text Add to dashboard Cite

show abstract

“…Previous studies have reported various non-invasive, real-time monitoring systems for thrombus detection based on electrical, sound, or optical principles (Ref. 14,15,16,17). However, previous studies have shown limitations such as the invasiveness of the evaluation, non-real-time evaluation, requirement for installing complex devices such as optical bers and cameras, and measurement impracticality.…”

Section: Discussionmentioning

confidence: 99%

Early Thrombus Detection in the Extracorporeal Membrane Oxygenation Circuit by Noninvasive Real-time Ultrasonic Sensors

Rim,

Lim,

Lee

et al. 2024

Preprint

View full text Add to dashboard Cite

Background Thrombus formation in extracorporeal membrane oxygenation (ECMO) remains a major concern as it can lead to fatal outcomes. To the best of our knowledge, there is no standard non-invasive method for quantitatively measuring thrombi. This study’s purpose was to verify thrombus detection in an ECMO circuit using novel, non-invasive ultrasonic sensors in real-time, utilizing the fact that the ultrasonic velocity in a thrombus is known to be higher than that in the blood. Methods Ultrasonic sensors with a customized chamber, an ultrasonic pulse-receiver, and a digital storage oscilloscope (DSO) were used to set up the measuring unit. The customized chamber was connected to an ECMO circuit primed with porcine blood. Thrombi formed from static porcine blood were placed in the circuit and ultrasonic signals were extracted from the oscilloscope at various ECMO flow rates of 1–4 L/min. Results The ultrasonic signal changes were successfully detected at each flow rate on the DSO. The ultrasonic pulse signal shifted leftward when a thrombus passed between the two ultrasonic sensors and was easily detected on the DSO screen. Conclusion This novel real-time non-invasive thrombus detection method may enable the early detection of floating thrombi in the ECMO system and early management of ECMO thrombi.

show abstract

“…4 In such cases, the risk of thrombotic complications will rise, thus increasing the need for realtime thrombus detection. Thus far, various approaches to real-time thrombus monitoring in extracorporeal circuits have been proposed based on electrical, 5,6 sound, 7,8 or Real-time, non-invasive thrombus detection in an extracorporeal circuit using micro-optical thrombus sensors 1 Sensing System Research Center, National Institute of Advanced Industrial Science and Technology (AIST), Tosu, Saga, Japan 2 Health and Medical Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Ibaraki, Japan optical [9][10][11][12] principles. However, invasiveness remains an issue with electrical monitoring techniques, as electrodes must be in contact with the blood.…”

Section: Introductionmentioning

confidence: 99%

“… 4 In such cases, the risk of thrombotic complications will rise, thus increasing the need for real-time thrombus detection. Thus far, various approaches to real-time thrombus monitoring in extracorporeal circuits have been proposed based on electrical, 5 , 6 sound, 7 , 8 or optical 9 – 12 principles. However, invasiveness remains an issue with electrical monitoring techniques, as electrodes must be in contact with the blood.…”

Section: Introductionmentioning

confidence: 99%

Real-time, non-invasive thrombus detection in an extracorporeal circuit using micro-optical thrombus sensors

et al. 2020

View full text Add to dashboard Cite

Introduction: Real-time, non-invasive monitoring of thrombus formation in extracorporeal circuits has yet to be achieved. To address the challenges of conventional optical thrombus detection methods requiring large devices that limit detection capacity, we developed a micro-optical thrombus sensor. Methods: The proposed micro-optical thrombus sensor can detect the intensity of light scattered by blood at wavelengths of 660 and 855 nm. Two thrombus sensors were installed on in vitro circuit: one at the rotary blood pump and one at a flow channel. To evaluate the variation in the ratio of incident light intensity at each wavelength of the two sensors, Rfluct (for 660 nm) and Ifluct (for 855 nm) were defined. Using fresh porcine blood as a working fluid, we performed in vitro tests of haematocrit (Hct) and oxygen saturation (SaO2) variation and thrombus detection. Thrombus tests were terminated after Rfluct or Ifluct showed a larger change than the maximum range of those in the Hct and SaO2 variation test. Results: In all three thrombus detection tests, Ifluct showed a larger change than the maximum range of those in the Hct and SaO2 variation test. After the tests, thrombus formation was confirmed in the pump, and there was no thrombus in the flow channel. The results indicate that Ifluct is an effective parameter for identifying the presence of a thrombus. Conclusion: Thrombus detection in an extracorporeal circuit using the developed micro-optical sensors was successfully demonstrated in an in vitro test.

show abstract

Cole-Cole analysis of thrombus formation in an extracorporeal blood flow circulation using electrical measurement

Cited by 17 publications

References 12 publications

Fatigue-Induced Cole Electrical Impedance Model Changes of Biceps Tissue Bioimpedance

Fatigue-Induced Cole Electrical Impedance Model Changes of Biceps Tissue Bioimpedance

Early Thrombus Detection in the Extracorporeal Membrane Oxygenation Circuit by Noninvasive Real-time Ultrasonic Sensors

Real-time, non-invasive thrombus detection in an extracorporeal circuit using micro-optical thrombus sensors

Contact Info

Product

Resources

About