2007
DOI: 10.1128/mmbr.00036-06
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Colicin Biology

Abstract: SUMMARY Colicins are proteins produced by and toxic for some strains of Escherichia coli. They are produced by strains of E. coli carrying a colicinogenic plasmid that bears the genetic determinants for colicin synthesis, immunity, and release. Insights gained into each fundamental aspect of their biology are presented: their synthesis, which is under SOS regulation; their release into the extracellular medium, which involves the colicin lysis protein; and their uptake mechanisms and modes of… Show more

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Cited by 984 publications
(1,397 citation statements)
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References 728 publications
(910 reference statements)
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“…In contrast, if plasmids are too rare, then there would be insufficient toxin and subsequent killing to compensate for the fixed costs of toxin production (Chao and Levin, 1981). The targets of bacteriocins are not always the same bacterial strain (Cascales et al, 2007). This presents an additional function for bacteriocin-carrying plasmids; if they are less efficient at infecting other strains, any plasmids that produce toxins to kill those strains will have an advantage from reducing competition with the strain it can more efficiently infect.…”
Section: Spiteful Traitsmentioning
confidence: 98%
“…In contrast, if plasmids are too rare, then there would be insufficient toxin and subsequent killing to compensate for the fixed costs of toxin production (Chao and Levin, 1981). The targets of bacteriocins are not always the same bacterial strain (Cascales et al, 2007). This presents an additional function for bacteriocin-carrying plasmids; if they are less efficient at infecting other strains, any plasmids that produce toxins to kill those strains will have an advantage from reducing competition with the strain it can more efficiently infect.…”
Section: Spiteful Traitsmentioning
confidence: 98%
“…Thus, it would seem that the hitherto unrecognized ability of Gram-positive bacteria to produce large proteinaceous antibiotics (bacteriocins) is relatively widely distributed. Indeed, it is tempting to speculate that this family of protein antibiotics may represent the Grampositive equivalent of the colicin family in Gram-negative bacteria (Cascales et al, 2007).…”
Section: Sa-m57 Enterococcin V583 Corynicin Jk and Ypkk[val88-trp16mentioning
confidence: 99%
“…Although from a biochemical perspective they exhibit an extraordinary diversity of structure, the bacteriocins can be loosely grouped into four categories, based on their molecular mass and whether the producing organism is Gram-positive or Gramnegative. For example, a number of species of the Enterobacteriaceae produce large, modular, antimicrobial proteins (M r .10 000) known as colicins (Cascales et al, 2007), whilst others produce relatively lower molecular mass antimicrobial peptides (M r ,10 000) termed microcins (Heng & Jack, 2006). Similarly, a veritable plethora of modified and unmodified peptide bacteriocins (M r ,10 000) from Gram-positive bacteria have also been described, particularly those elaborated by the lactic acid bacteria (Bonelli et al, 2006;Nes et al, 2006;Heng et al, 2007).…”
Section: Introductionmentioning
confidence: 99%
“…The Gram-negative bacterium Escherichia coli is one of the best documented organisms with regard to microbial allelopathy. The bacteriocins it produces, termed colicins, were first discovered and identified by the Belgian researcher André Gratia in 1925 (reviewed by Cascales et al, 2007). The bacteriocins produced by Pseudomonas species are called pyocins, and, in contrast to colicins whose genes are plasmid-borne, the pyocin genes are found in the chromosome (Sano & Kageyama, 1984;Shinomiya et al, 1983).…”
Section: Introductionmentioning
confidence: 99%