Distributed, on-demand, data-intensive, and collaborative simulation analysis tools are being developed by an international team to solve real problems such as bioinformatics applications. The project consists of three distinct focuses: compute, visualize, and collaborate. Each component utilizes software and hardware that performs across the International Grid. Computers in North America, Asia, and Europe are working on a common simulation programs. The results are visualized in a multi-way 3D visualization collaboration session where additional compute requests can be submitted in real-time. Navigation controls and data replication issues are addressed and solved with a scalable solution. Published by Elsevier B.V.