Collaborative governance implemented by pentahelix actors is urgently needed to reduce the spread of COVID-19 in Makassar. The purpose of this study was to analyze the implementation of collaborative governance during the COVID-19 pandemic in Makassar. This study used qualitative research with an explanatory level of analysis. Information sources were taken from 10 pentahelix actors, i.e., government, private sector, civil society, media and academician. The data were collected from December 2021 to January 2022 using a triangulation method. The integrative framework for collaborative governance by Emerson et al. (2012) guided the data collection and analysis. The results of the research showed that the implementation of collaborative governance was successful in preventing the COVID-19 pandemic in Makassar. Three variables of the collaborative governance regime, (1) collaboration dynamics, i.e., a) principled engagement, (b) shared motivation, and (c) capacity for joint action, 2) collaborative actions, and 3) collaborative outcome, showed excellent accomplishment to prevent the COVID-19 pandemic in Makassar.