Collaborative work on evaluation of ovarian toxicity 17) Two- or four-week repeated-dose studies and fertility study of sulpiride in female rats

Ishii, Shun-ichiro; Ube, Masayuki; Okada, Mitsuru; Adachi, Tamiko; Sugimoto, Jiro; Inoue, Yoshimi; Uno, Yoshifumi; Mutai, Mamoru

doi:10.2131/jts.34.s175

Cited by 14 publications

(7 citation statements)

References 18 publications

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“… 30 Davis et al (1997), 40 Dodo et al (2009), 82 Ishii et al. (2009), 164 Rehm et al (2007), 175 Shibayama et al (2009), 188 Taketa et al (2011), 214 Yuan and Foley (2002)…”

Section: Morphologymentioning

confidence: 99%

Nonproliferative and Proliferative Lesions of the Rat and Mouse Female Reproductive System

Alison²,

et al. 2014

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The INHAND (International Harmonization of Nomenclature and Diagnostic Criteria for Lesions in Rats and Mice) Project (www.toxpath.org/inhand.asp) is a joint initiative of the Societies of Toxicological Pathology from Europe (ESTP), Great Britain (BSTP), Japan (JSTP) and North America (STP) to develop an internationally accepted nomenclature for proliferative and nonproliferative lesions in laboratory animals. The purpose of this publication is to provide a standardized nomenclature for classifying microscopic lesions observed in the female reproductive tract of laboratory rats and mice, with color photomicrographs illustrating examples of some lesions. The standardized nomenclature presented in this document is also available electronically on the internet (http://www.goreni.org/). Sources of material included histopathology databases from government, academia, and industrial laboratories throughout the world. Content includes spontaneous and aging lesions as well as lesions induced by exposure to test materials. There is also a section on normal cyclical changes observed in the ovary, uterus, cervix and vagina to compare normal physiological changes with pathological lesions. A widely accepted and utilized international harmonization of nomenclature for female reproductive tract lesions in laboratory animals will decrease confusion among regulatory and scientific research organizations in different countries and provide a common language to increase and enrich international exchanges of information among toxicologists and pathologists.

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“… 30 Davis et al (1997), 40 Dodo et al (2009), 82 Ishii et al. (2009), 164 Rehm et al (2007), 175 Shibayama et al (2009), 188 Taketa et al (2011), 214 Yuan and Foley (2002)…”

Section: Morphologymentioning

confidence: 99%

Nonproliferative and Proliferative Lesions of the Rat and Mouse Female Reproductive System

Alison²,

et al. 2014

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“…After 1 week, 72 rats (24 in each group) were assigned to three groups: control (basal diet), sulpiride (200 ppm in the diet) and EGME (1250 ppm in drinking water). The effective doses in genital organs were selected and calculated based on relevant literature (Dodo et al, ; Ishii et al, ; Taketa et al, ).…”

Section: Methodsmentioning

confidence: 99%

Effects of sulpiride and ethylene glycol monomethyl ether on endometrial carcinogenicity in Donryu rats

Taketa

Inoue

Takahashi

et al. 2015

J of Applied Toxicology

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Sulpiride and ethylene glycol monomethyl ether (EGME) are known ovarian toxicants that stimulate prolactin (PRL) secretion, resulting in hypertrophy of the corpora lutea and increased progesterone (P4) production. The purpose of the present study was to investigate how the PRL stimulatory agents affected uterine carcinogenesis and to clarify the effects of PRL on endometrial adenocarcinoma progression in rats. Ten-week-old female Donryu rats were treated once with N-ethyl-N'-nitro-N-nitrosoguanidine (20 mg kg(-1) ), followed by treatment with sulpiride (200 ppm) or EGME (1250 ppm) from 11 weeks of age to 12 months of age. Sulpiride treatment inhibited the incidence of uterine adenocarcinoma and precancerous lesions of atypical endometrial hyperplasia, whereas EGME had no effect on uterine carcinogenesis. Sulpiride markedly prevented the onset of persistent estrus throughout the study period, and EGME delayed and inhibited the onset of persistent estrus. Moreover, sulpiride-treated animals showed high PRL and P4 serum levels without changes in the levels of estradiol-17β, low uterine weights and histological luteal cell hypertrophy. EGME did not affect serum PRL and P4 levels. These results suggest that the prolonged low estradiol-17β to P4 ratio accompanied by persistent estrous cycle abnormalities secondary to the luteal stimulatory effects of PRL may explain the inhibitory effects of sulpiride on uterine carcinogenesis in rats. Copyright © 2015 John Wiley & Sons, Ltd.

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“…This can be accompanied by a concomitant histological change of superficial mucification within the vagina, characteristic of persistent diestrus/'pseudopregnancy', a feature also induced by the administration of progestational compounds (Gopinath, ). It should be noted, however, that the administration of some high‐dose dopamine antagonists may lead to ovarian follicular cysts/atresia, with accompanying abnormalities in cyclicity (Ishii et al , ).…”

Section: Preclinical Detection Of Drug‐induced Hypo‐/hyperprolactinemiamentioning

confidence: 99%

“…Other effects noted in female rodents subject to drug‐induced hyperprolactinemia include mammary gland hyperplasia and an induction of lactogenic secretion (Ishii et al , ; Lucas et al , ), in addition to increased food consumption and bodyweight gain, the latter possibly arising from the inhibition of leptin signalling (Lucas et al , ; Denis et al , ; Xu et al , ).…”

Section: Preclinical Detection Of Drug‐induced Hypo‐/hyperprolactinemiamentioning

confidence: 99%

Preclinical risk assessment of drug‐induced hypo‐ and hyperprolactinemia

Hargreaves

Harleman

2011

J of Applied Toxicology

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Drug-induced changes in prolactin signaling may obscure interpretation of preclinical toxicological endpoints. However, with informed consideration, classic hallmarks of hypo-/hyperprolactinemia can be recognized in short- and long-term rodent bioassays. Findings can be supported and expanded with additional in vivo and in vitro datasets. When taken together with human epidemiological evidence pertaining to the consequences of drug-induced hypo-/hyperprolactinemia, such findings permit both an analysis of human relevance and an assessment of human risk.

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Collaborative work on evaluation of ovarian toxicity 17) Two- or four-week repeated-dose studies and fertility study of sulpiride in female rats

Cited by 14 publications

References 18 publications

Nonproliferative and Proliferative Lesions of the Rat and Mouse Female Reproductive System

Nonproliferative and Proliferative Lesions of the Rat and Mouse Female Reproductive System

Effects of sulpiride and ethylene glycol monomethyl ether on endometrial carcinogenicity in Donryu rats

Preclinical risk assessment of drug‐induced hypo‐ and hyperprolactinemia

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