2015
DOI: 10.1152/ajplung.00039.2015
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Collagen and elastin cross-linking is altered during aberrant late lung development associated with hyperoxia

Abstract: RE. Collagen and elastin cross-linking is altered during aberrant late lung development associated with hyperoxia. Am J Physiol Lung Cell Mol Physiol 308: L1145-L1158, 2015. First published April 3, 2015 doi:10.1152/ajplung.00039.2015.-Maturation of the lung extracellular matrix (ECM) plays an important role in the formation of alveolar gas exchange units. A key step in ECM maturation is cross-linking of collagen and elastin, which imparts stability and functionality to the ECM. During aberrant late lung deve… Show more

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Cited by 67 publications
(81 citation statements)
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“…A significant increase of airspace measured by mean linear intercepts or radial alveolar counts was also achieved after a postnatal exposure of neonatal mice to 65% or 60% oxygen for seven days [62,63]. Chronical hyperoxia models with 80 or 85% oxygen exposure for 28 days also resulted in enlarged alveoli, partly with increased septal wall thickness [22,64,65]. Thus, the degree of BPD-like delay in lung development depends on the oxygen dose, the administration period and the timing as well as on the morphometric parameters.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…A significant increase of airspace measured by mean linear intercepts or radial alveolar counts was also achieved after a postnatal exposure of neonatal mice to 65% or 60% oxygen for seven days [62,63]. Chronical hyperoxia models with 80 or 85% oxygen exposure for 28 days also resulted in enlarged alveoli, partly with increased septal wall thickness [22,64,65]. Thus, the degree of BPD-like delay in lung development depends on the oxygen dose, the administration period and the timing as well as on the morphometric parameters.…”
Section: Discussionmentioning
confidence: 99%
“…However, the relative gene expression of elastin, one of the numerous factors, which are jointly responsible for normal alveolarization [64,79] did not change significantly in our double hit model [25]. Relative hyperoxia following premature birth may lead to a reduction of the HIF-α, and so to decreased levels of VEGF, resulting in an interruption of vascularization, but also of alveolar formation [80].…”
Section: Discussionmentioning
confidence: 99%
“…The dose was chosen based on a previous study61. This protocol was reviewed and approved by the Institutional Animal Care and Use Committee.…”
Section: Methodsmentioning
confidence: 99%
“…The expression of many of these molecules is dysregulated during aberrant lung development 152 . In general, the overall abundance of elastin is reduced, and elastin fibers in the developing septa are disorganized; although the general abundance of collagen and collagen cross-links is increased 153 , and collagen fibers also take on an abnormal structure 154 . How these changes directly result in disturbed lung development is not clear, and remains to be defined.…”
Section: Disruption Of Essential Developmental Pathwaysmentioning
confidence: 99%