Collagen based magnetic nanobiocomposite as MRI contrast agent and for targeted delivery in cancer therapy

Mandal, Asit Baran; Sekar, S.; Kanagavel, M.; Chandrasekaran, N.; Mukherjee, Amitava; Sastry, T. P.

doi:10.1016/j.bbagen.2013.05.018

Cited by 24 publications

(11 citation statements)

References 30 publications

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“…the resistance to change for the composite developed in this study was greater than 19% as against 3% reported for poly (lactide-ε-caprolactone)/collagen/nano-hydroxyapatite composite80. Compared to previous reports81 the nanoparticles developed in this study had a lower cytotoxicity due to the presence of the polysaccharide corona, leading to the possibility of offering higher doses of collagen-nanoparticle composites for imaging purposes. The polysaccharide corona also provides for a higher r 1 at low r 2 /r 1 , leading to its function as a better T 1 contrast agent.…”

Section: Resultscontrasting

confidence: 49%

Fluorescent nanonetworks: A novel bioalley for collagen scaffolds and Tissue Engineering

Nidhin

Vedhanayagam

Sangeetha

et al. 2014

Sci Rep

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Native collagen is arranged in bundles of aligned fibrils to withstand in vivo mechanical loads. Reproducing such a process under in vitro conditions has not met with major success. Our approach has been to induce nanolinks, during the self-assembly process, leading to delayed rather than inhibited fibrillogenesis. For this, a designed synthesis of nanoparticles - using starch as a template and a reflux process, which would provide a highly anisotropic (star shaped) nanoparticle, with large surface area was adopted. Anisotropy associated decrease in Morin temperature and superparamagnetic behavior was observed. Polysaccharide on the nanoparticle surface provided aqueous stability and low cytotoxicity. Starch coated nanoparticles was utilized to build polysaccharide - collagen crosslinks, which supplemented natural crosslinks in collagen, without disturbing the conformation of collagen. The resulting fibrillar lamellae showed a striking resemblance to native lamellae, but had a melting and denaturation temperature higher than native collagen. The biocompatibility and superparamagnetism of the nanoparticles also come handy in the development of stable collagen constructs for various biomedical applications, including that of MRI contrast agents.

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Section: Resultscontrasting

confidence: 49%

Fluorescent nanonetworks: A novel bioalley for collagen scaffolds and Tissue Engineering

Nidhin

Vedhanayagam

Sangeetha

et al. 2014

Sci Rep

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“…Modifications of magnetic NPs make them interesting options for cancer therapeutic systems. Collagen-based magnetic nanobiocomposites have been established as an MRI contrast agent and as a carrier for delivering cancer drugs [128]. Since iron oxide NPs use folate receptors to enter cells, over-expression of this receptor on the surface of cancer cells, as previously demonstrated [129], may be a useful point for an anticancer drug delivery approach using these NPs [130].…”

Section: Iron Oxide Nanoparticlesmentioning

confidence: 99%

Metal, Metalloid, and Oxide Nanoparticles for Therapeutic and Diagnostic Oncology

Yazdi¹,

Sepehrizadeh²,

Mahdavi³

et al. 2016

Nano BioMed ENG

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Nanoparticles have comprehensively affected various sights of human life. Through the wide range of claims about nanosized particles and their functions, biomedical applications are of much interest among health care researchers due to the nanoparticles' potential for use in the process of disease diagnosis, control and treatment. In this regard, inorganic nanoparticles, which have high potential in diagnostic and therapeutic systems, have recently received much attention in oncology. Although inorganic nanoparticles initially seemed an appropriate tool for cancer imaging and diagnosis, their ability to attack cancerous cells as anticancer drugs or carriers in other drugs has also demonstrated promising results. The present review primarily provides a brief survey of various studies in which metal nanoparticles such as gold, silver, iron oxide, and metalloid nanoparticles viz. tellurium and bismuth were exploited for therapeutic or diagnostic purposes in oncology. Then the application of selenium nanoparticles as a therapeutic agent against cancer in in vitro and in vivo studies is reviewed in detail. Although inorganic nanoparticles seem to be useful tools for cancer imaging and diagnosis, their potential for attacking cancerous cells as anticancer substances or even carriers for anticancer medications should not be underestimated.

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“…Naskar, Ghosh, and Moulik (2012) have also recently reported about the effect of various additives on aqueous normal and reverse PEO/PPO micelles. Therefore, even though there are a variety of structures including microspheres (Mathiowitz et al, 1997;Matsumoto, Matsukawa, Suzuki, Yoshino, & Kobayashi, 1997), dendrimers (Gillies & Frechet, 2005), liposomes (Allen, 1998;Ramachandran, Quist, Kumar, & Lal, 2006;Samad, Sultana, & Aqil, 2007;Yatvin, Weinstein, Dennis, & Blumenthal, 1978), carbon nanohorns (Ajima et al, 2005(Ajima et al, , 2008Murakami et al, 2004), carbon nanotubes (Guven et al, 2012), and nanoparticles; gold (Mohanty, Thennarasu, & Mandal, 2014), silver , Fe 3 O 4 (Cheng, Peng, Xu, & Sun, 2009;Mandal, Sekar, Kanagavel, et al, 2013), pH-responsive compounds (Oishi, Hayashi, Iijima, & Nagasaki, 2007;Xu et al, 2006), and silica (Barbe et al, 2004;Slowing, Trewyn, Giri, & Lin, 2007); that can be used as drug delivery agents, polymeric micelles' high drug-loading ability and toxicity shield effect (Cammas & Kataoka, 1996;Kreuter et al, 1994;Kwon & Kataoka, 1995;Kwon & Okano, 1996;Scholes et al, 1997) suggests they are sufficient drug delivery platforms to compliment other used drug delivery materials.…”

Section: Introductionmentioning

confidence: 99%

The Kinetics of Gel Formation for PEO−PPO−PEO Triblock Copolymer Solutions and the Effects of Added Methylparaben

Meznarich

Love

2011

Macromolecules

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Dynamic diffusion experiments were performed on aqueous polymeric micelles mixed with malachite green (0.05% mass v −1), erythrosin (0.1% mass v −1), and cisplatin (0.1% mass v −1) to gauge release from sequestered structures using ultraviolet-visible spectroscopy. The additives were formulated with 20% mass v −1 aqueous solutions of polyethylene oxide-polypropylene oxide-polyethylene oxide, PEO-PPO-PEO (F127). Each additive was tested neat at room temperature, neat at 40 C, and formulated with F127 at room temperature, and 40 C. After constructing calibration curves, the dynamic release for each ternary additive and corresponding diffusion coefficients were calculated. Results show that F127 retards permeation at room temperature. In general, the neat additives at 40 C showed the highest permeability for both malachite green and erythrosin. Malachite green released almost 90% of the dye by 60 min of permeation. When formulated with F127 at 40 C, sizeable release was still noted, but with an induction period of 10-30 min to register release. The behavior with cisplatin was more complicated as the first 5 h of permeation resulted in a burst delivery with cisplatin (6% total release with cisplatin-F127-RT compared to 4% total release cisplatin-RT) but with overall lower release. The higher fluence at elevated temperature is attributed to reducing the blocking effect of the amphiphiles on the walls of the dialysis tubing as they are directed to form colloidal gels. There is also likely a correlation between higher temperature and higher overall permeability if the membrane pores also expand with temperature. Keywords Surfactant Á Cisplatin Á Diffusion Á Drug delivery Á Malachite green chloride Á Erythrosin B dye

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Collagen based magnetic nanobiocomposite as MRI contrast agent and for targeted delivery in cancer therapy

Cited by 24 publications

References 30 publications

Fluorescent nanonetworks: A novel bioalley for collagen scaffolds and Tissue Engineering

Fluorescent nanonetworks: A novel bioalley for collagen scaffolds and Tissue Engineering

Metal, Metalloid, and Oxide Nanoparticles for Therapeutic and Diagnostic Oncology

The Kinetics of Gel Formation for PEO−PPO−PEO Triblock Copolymer Solutions and the Effects of Added Methylparaben

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