Collagen Biosynthesis in Nonfibroblastic Cell Lines

Langness, U; Undenfriend, Sidney

doi:10.1073/pnas.71.1.50

Cited by 58 publications

(18 citation statements)

References 11 publications

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“…There is now considerable evidence that all cell lines in tissue culture, with the possible exception of lymphomata (Goldberg and Green, 1969), produce collagen and contain prolyl hydroxylase (Langness and Udenfriend, 1974) while in vivo there is evidence that aortic smooth muscle cells produce collagen (Ross and Glomset, 1973). In addition, it has been shown that normal corneal epithelium produces interstitial and basement membrane collagen (Trelstad, Hayashi and Toole, 1974) and that other epithelia produce basement membrane collagen (Pierce, 1970 …”

Section: Discussionmentioning

confidence: 99%

Inappropriate production of collagen and prolyl hydroxylase by human breast cancer cells in vivo

Al-Adnani¹,

Kirrane²,

McGee³

1975

Br J Cancer

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Summary.-Thirty-two scirrhous cancers of breast have been examined to determine the origin of the collagen stroma in these tumours. Employing two immunohistochemical techniques it has been shown that the malignant epithelial cells in 30 of these tumours contain not only collagen but also prolyl hydroxylase, a key enzyme in collagen biosynthesis. Neither this enzyme nor collagen was detectable in the spindle cells in the stroma of these tumours. Neither the epithelium in normal breast, that in fibrocystic disease and in fibroadenomata, nor the malignant epithelium in two medullary cancers of breast contained either collagen or prolyl hydroxylase. These results strongly suggest that the malignant epithelium of scirrhous breast cancers produces its own collagen stroma and that the scirrhous reaction in these tumours is not a host response to tumour invasion. The production of collagen and prolyl hydroxylase by breast cancer cells (of the scirrhous type) therefore represents another example of inappropriate protein production by a human tumour.

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Section: Discussionmentioning

confidence: 99%

Inappropriate production of collagen and prolyl hydroxylase by human breast cancer cells in vivo

Al-Adnani¹,

Kirrane²,

McGee³

1975

Br J Cancer

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“…Although production of collagen decreases when a critically low oxygen level is reached (92), collagen deposition is enhanced with elevated concentrations of lactate (93,94). Therefore, by releasing high levels of lactate (25), macrophages indirectly contribute to collagen formation.…”

Section: Oxygen and Lactatementioning

confidence: 99%

Tendon Healing: Repair and Regeneration

Voleti

Buckley

Soslowsky

2012

Annu. Rev. Biomed. Eng.

421

356

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Injury and degeneration of tendon, the soft tissue that mechanically links muscle and bone, can cause substantial pain and loss of function. This review discusses the composition and function of healthy tendon and describes the structural, biological, and mechanical changes initiated during the process of tendon healing. Biochemical pathways activated during repair, experimental injury models, and parallels between tendon healing and tendon development are emphasized, and cutting-edge strategies for the enhancement of tendon healing are discussed.

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“…In this Opinion article, we focus on how hypoxia affects extracellular matrix (ECM) deposition, remodelling and degradation, which might potentiate cancer metastasis. Central to this emerging paradigm are three crucial findings: the ECM is a dynamic structure that influences tumour progression 13–18 ; multiple cell types, including cancer cells, contribute to ECM production 19–23 ; and the remodelled ECM within regions of intratumoural hypoxia could be a pathway rather than an obstacle for cancer metastasis 24–27 .…”

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confidence: 99%

Hypoxia and the extracellular matrix: drivers of tumour metastasis

2014

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Of the deaths attributed to cancer, 90% are due to metastasis, and treatments that prevent or cure metastasis remain elusive. Emerging data indicate that hypoxia and the extracellular matrix (ECM) might have crucial roles in metastasis. During tumour evolution, changes in the composition and the overall content of the ECM reflect both its biophysical and biological properties and these strongly influence tumour and stromal cell properties, such as proliferation and motility. Originally thought of as independent contributors to metastatic spread, recent studies have established a direct link between hypoxia and the composition and the organization of the ECM, which suggests a new model in which multiple microenvironmental signals might converge to synergistically influence metastatic outcome.

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Collagen Biosynthesis in Nonfibroblastic Cell Lines

Abstract: Prolyl hydroxylase and other enzymes of collagen synthesis have been found in cloned cells, including epithelium, melanoma, liver, HeLa, pituitary, kidney, and neuroblastoma. The significance of collagen biosynthesis in nonfibroblastic cells lines is discussed.

Cited by 58 publications

References 11 publications

Inappropriate production of collagen and prolyl hydroxylase by human breast cancer cells in vivo

Inappropriate production of collagen and prolyl hydroxylase by human breast cancer cells in vivo

Tendon Healing: Repair and Regeneration

Hypoxia and the extracellular matrix: drivers of tumour metastasis

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