Collagen-coated silk fibroin nanofibers with antioxidants for enhanced wound healing

Selvaraj, Sowmya; Inbasekar, Chandrasekar; Pandurangan, Suryalakshmi; Fathima, Nishter Nishad

doi:10.1080/09205063.2022.2106707

Cited by 13 publications

(7 citation statements)

References 34 publications

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“…Our results were following previous results, which showed SN efficacy in positive regulation of subepithelial collagen deposition, and other tissue proteins that helped in relieving Airway remodeling in mice with asthma [ 62 ]. Similar effects of SN on the positive regulation of hydroxyproline and collagen proteins have been found in a nanofiber study for wound healing [ 63 ].…”

Section: Discussionsupporting

confidence: 70%

Sinomenine accelerate wound healing in rats by augmentation of antioxidant, anti-inflammatory, immunuhistochemical pathways

Jabbar,

Abdul-Aziz Ahmed,

Abdulla

et al. 2024

Heliyon

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Section: Discussionsupporting

confidence: 70%

Sinomenine accelerate wound healing in rats by augmentation of antioxidant, anti-inflammatory, immunuhistochemical pathways

Jabbar,

Abdul-Aziz Ahmed,

Abdulla

et al. 2024

Heliyon

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“…About 5 mg of the scaffold was treated with 2 ml of 100 µM solution of DPPH and incubated in the dark for 30 min. The DPPH solution in methanol served as blank, and optical density was measured at 517 nm [24]. The degradation of DPPH by scaffold was calculated by following formula Antioxidant activity = Absorbance of blank − Absorbance of sample Absorbance of blank × 100.…”

Section: Antioxidant Activitymentioning

confidence: 99%

In vivo soft tissue regenerative potential of flax seed mucilage self-assembled collagen aerogels

Kumari,

Ahina,

Kannan

et al. 2024

Biomed. Mater.

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The present study demonstrates the in vivo soft tissue regenerative potential of flax seed mucilage (FSM) reinforced collagen aerogels in Wistar rats. The physiochemical, mechanical, and thermal properties were significantly improved upon the incorporation of flax mucilage into collagen when compared to the native collagen scaffold. In addition, the functional group of flax mucilage notably contributed towards the better anti-oxidative potential than the control collagen. The flax mucilage-reinforced collagen at 4mg/ml concentration showed 2 fold increase in porosity compared to native collagen. The tensile strength of native collagen, 2mg/ml, and 4mg/ml FSM reinforced collagen was 5.22 MPa, 9.76 MPa, and 11.16 MPa, respectively which indicated that 2mg/ml and 4mg/ml FSM showed a 87% and 113% percentage increase respectively in tensile strength compared to the native collagen control. FSM-reinforced biomatrix showed 97% wound closure on day 15 post-wounding, indicating faster healing than controls, where complete healing occurred only on day 21. The mechanical properties of skin treated with FSM-reinforced collagen scaffold post-healing were considerably better than native collagen. The histological and immunohistochemistry analysis also showed complete restoration of wounded tissue like intact normal skin. The findings paved the way for the development of collagen-polysaccharide mucilage wound dressing materials and their further application in skin tissue engineering.

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“…Collagen/silk fibroin scaffolds have high porosity and excellent biocompatibility, which make them promising biomaterials for bone tissue engineering . However, due to their low mechanical properties, they are difficult to use for mandible reconstruction . Hydroxyapatite (HA) is the main inorganic component of the bone, thus representing an outstanding bone substitute material.…”

Section: Introductionmentioning

confidence: 99%

“…15 However, due to their low mechanical properties, they are difficult to use for mandible reconstruction. 16 Hydroxyapatite (HA) is the main inorganic component of the bone, thus representing an outstanding bone substitute material. The addition of an appropriate amount of HA can obviously improve the mechanical properties of composite materials.…”

Section: Introductionmentioning

confidence: 99%

Silk Fibroin/Collagen/Hydroxyapatite Scaffolds Obtained by 3D Printing Technology and Loaded with Recombinant Human Erythropoietin in the Reconstruction of Alveolar Bone Defects

Liu

Wang

Sun

et al. 2022

ACS Biomater. Sci. Eng.

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The fast osteogenesis of the large alveolar fossa and the maintenance of the height of the alveolar ridge after tooth extraction have always been a clinical challenge. Therefore, this work describes the creation of innovative silk fibroin/collagen/ hydroxyapatite (SCH) biological scaffolds by 3D printing technology, which are loaded with recombinant human erythropoietin (rh-EPO) for the reconstruction of bone defects. Low-temperature 3D printing can maintain the biological activity of silk fibroin and collagen. The SCH scaffolds showed the ideal water absorption and porosity, being a sustained-release carrier of rh-EPO. The optimized scaffolds had ideal mechanical properties in vitro, and MC3T3-E1 cells could easily adhere and proliferate on it. In vivo experiments in rabbits demonstrated that the composite scaffolds gradually degraded and promoted the accumulation and proliferation of osteoblasts and the formation of collagen fibers, significantly promoting the reconstruction of mandibular defects. In this study, a novel composite biological scaffold was prepared using 3D printing technology, and the scaffold was innovatively combined with the multifunctional growth factor rh-EPO. This provides a new optimized composite material for the reconstruction of irregular mandible defects, and this biomaterial is promising for clinical reconstruction of alveolar bone defects.

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Collagen-coated silk fibroin nanofibers with antioxidants for enhanced wound healing

Cited by 13 publications

References 34 publications

Sinomenine accelerate wound healing in rats by augmentation of antioxidant, anti-inflammatory, immunuhistochemical pathways

Sinomenine accelerate wound healing in rats by augmentation of antioxidant, anti-inflammatory, immunuhistochemical pathways

In vivo soft tissue regenerative potential of flax seed mucilage self-assembled collagen aerogels

Silk Fibroin/Collagen/Hydroxyapatite Scaffolds Obtained by 3D Printing Technology and Loaded with Recombinant Human Erythropoietin in the Reconstruction of Alveolar Bone Defects

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