Collagen Fiber Anchoring Platforms for Percutaneous Devices

Arita, Takayuki; Asoda, Seiji; Koshitomae, Hazuki; Katakura, Hiroshi; Takakuda, Kazuo

doi:10.1097/mat.0b013e3181d034f6

Cited by 6 publications

(3 citation statements)

References 17 publications

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“…It is debated whether there is a true skin-implant integration and complete seal for percutaneous implants. 36 Some authors have found cellular attachment, 37 however, available evidence suggests that there is no true in vivo attachment. 38 Instead, microorganisms and tissue debris are expelled outwards along the implant-interface.…”

Section: Discussionmentioning

confidence: 99%

Integration between a percutaneous implant and the porcine small bowel

Johansson¹,

Thomsen²,

Hultén³

et al. 2011

J Biomed Mater Res

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Inflammatory bowel diseases, cancer or trauma may require removal of all or part of the intestines, leaving the patient with a need to wear external stoma appliances for collection of bowel contents. By connecting the small bowel to a percutaneous port, equipped with a sealing lid, a fully continent and leak proof stoma can be created without a need for permanently wearing stoma appliance. The prerequisites for a connection between a permanent, transabdominal implant and a visceral organ are largely unexplored. Stoma ports made of titanium were implanted in the abdominal wall of domestic pigs and a branch of distal ileum was inserted through the ports. After being followed for 1-3 weeks, the ports were removed and subjected to histological evaluation to study the influence of their shape, structure, and position on the tissue response. Particular focus was attended to the attachment of the ileal serosal surface to the implants inner structure consisting of a titanium mesh. Macroscopic examination revealed fistulas and formation of abscesses in 4 of 11 the retrieved implants. Histological examination revealed regenerated and well-vascularized collagenous tissue around the mesh structure inside the implant. The integration was complete or partial for 10 of 11 ports. Despite various degrees of inflammation and tissue ingrowth, it was demonstrated for the first time that the serosal surface of ileum was firmly attached to the internal structure of the implant. These experiments provide a basis for optimization of the implant and surgical procedure before long-term functional animal experiments.

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Section: Discussionmentioning

confidence: 99%

Integration between a percutaneous implant and the porcine small bowel

Johansson¹,

Thomsen²,

Hultén³

et al. 2011

J Biomed Mater Res

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show abstract

“…It is debated whether there is a true skin–implant integration and complete seal for percutaneous implants 36. Some authors have found cellular attachment,37 however, available evidence suggests that there is no true in vivo attachment 38.…”

Section: Discussionmentioning

confidence: 99%

Friendly to environment heterocyclic adducts as corrosion inhibitors for steel in water‐borne paints

Mohamed

Farag

Badran

2010

J of Applied Polymer Sci

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Two groups of emulsion paints were formulated to evaluate the efficiency of emulsified heterocyclic adducts: 2-mercaptothiazoline (2-MT), 2-mercaptobenzothiazole (2-MBT), 2-mercapto-5-methyl-1,3, 4-thiadiazole (2-MMT), and 3-mercapto-4-methyl-4H-1,2,4-triazole (3-MMT). Different concentrations of 2-MT adduct, which has the simplest structure were added in waterborne paint formulations based on urabrid AC 100 emulsion resin to detect the optimum concentration range of the adduct as corrosion inhibitor. The efficiency of all the emulsified adducts has been studied at constant concentration within the optimum range in order to arrange them according to their efficiency as corrosion inhibitor for mild steel. Chemical, mechanical, corrosion resistance and water up-take tests of paint films were measured. Weight loss measurements (mg/cm 2 ), for steel panels under paint films and the steel corrosion inhibition efficiency of adduct has been determined. It was found that the prepared water-borne adducts could protect steel from corrosion and their efficiencies as corrosion inhibitors could be arranged in descending order: 3-MMT > 2-MMT > 2-MBT > 2-MT adducts.

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“…9 The second strategy involves the control of adhesion between the catheter cuff and subcutaneous tissue. Structure-controlled materials such as Dacron cuff, 10 sintered titanium mesh, 11 silk fibroin, or collagen fibers 12,13 have been used to prevent epithelial down growth. Modified surfaces have also been employed, including immobilized collagen, 14 bioactive glass, 15 hydroxyapatite, 16 and laminin–apatite composites.…”

Section: Introductionmentioning

confidence: 99%

Prevention of catheter infection using a biodegradable tissue adhesive composed of human serum albumin and disuccinimidyl tartrate

Taguchi

Okada

Kogai

et al. 2014

Journal of Bioactive and Compatible Polymers

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A new material was prepared to reduce catheter infection composed of a flocked silicone sheet (AmTiO 2 NP-F) with TiO 2 nanoparticle-immobilized poly(ethylene terephthalate) fibers modified with surface amino groups. This system was used in conjunction with a tissue adhesive composed of disuccinimidyl tartrate and human serum albumin. At a fixed disuccinimidyl tartrate content of 0.2 mmol in human serum albumin solution, AmTiO 2 NP-F bonded well with collagen-based casing (a model material for skin), with bond strength increasing to a maximum of 38 w/v% human serum albumin. The adhesive bonded AmTiO 2 NP-F to subcutaneous tissue in mice, and infiltration of the tissue into the AmTiO 2 NP-F further increased the bond strength for long-term insertions. The material was degraded within 7 days of implantation, and tissue reaction was mild, while infection was completely prevented. These results indicate that the combined use of AmTiO 2 NP-F and

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Collagen Fiber Anchoring Platforms for Percutaneous Devices

Cited by 6 publications

References 17 publications

Integration between a percutaneous implant and the porcine small bowel

Integration between a percutaneous implant and the porcine small bowel

Friendly to environment heterocyclic adducts as corrosion inhibitors for steel in water‐borne paints

Prevention of catheter infection using a biodegradable tissue adhesive composed of human serum albumin and disuccinimidyl tartrate

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