Prevention of catheter infection using a biodegradable tissue adhesive composed of human serum albumin and disuccinimidyl tartrate

Abstract

A new material was prepared to reduce catheter infection composed of a flocked silicone sheet (AmTiO 2 NP-F) with TiO 2 nanoparticle-immobilized poly(ethylene terephthalate) fibers modified with surface amino groups. This system was used in conjunction with a tissue adhesive composed of disuccinimidyl tartrate and human serum albumin. At a fixed disuccinimidyl tartrate content of 0.2 mmol in human serum albumin solution, AmTiO 2 NP-F bonded well with collagen-based casing (a model material for skin), with bond strength increasing to a maximum of 38 w/v% human serum albumin. The adhesive bonded AmTiO 2 NP-F to subcutaneous tissue in mice, and infiltration of the tissue into the AmTiO 2 NP-F further increased the bond strength for long-term insertions. The material was degraded within 7 days of implantation, and tissue reaction was mild, while infection was completely prevented. These results indicate that the combined use of AmTiO 2 NP-F and

Injectable PAMAM/ODex double-crosslinked hydrogels with high mechanical strength

“…These results showed PAMAM/ODex hydrogels have potential to serve as adhesives. Of note is the fact that the adhesive strength was not as high as other adhesives reported recently [35,53,54]. This may be explained by the balance between cohesion and adhesion [55,56].…”

“…As described in previous literature [35,36], collagen casing was used as a substrate to test hydrogel adhesive strength. The collagen casing was cut into 80 × 15 mm 2 rectangle pieces and stored in PBS (pH 7.4) until the measurement.…”