Collagen formation ? observations on its intracellular packaging and transport

Weinstock, Melvyn

doi:10.1007/bf00316743

Cited by 78 publications

(21 citation statements)

References 28 publications

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“…Vesicles, probably derived from denuded regions of the rough endoplasmic reticulum, were noted on the forming face of the Golgi apparatus. Ad ditional vesicles, apparently derived from the second, third and fourth stacks of the Golgi, housed secretory materials in various phases of condensation, which were similar to those reported in the odontoblasts of the rat molar \Reilh, 1968a, b]and incisor [Weinstock, 1972: Weinstock and, These conden sations were probably precollagenous in na ture [Reith, 1968a, b: Weinstock, 1972Wein stock and Leblond, 1974]. Additional secretory vesicles, containing a homogeneous, electrondense material, were also noted.…”

Section: Discussionsupporting

confidence: 71%

“…The Golgi region of the secretory odonto blast contained vesicles of various types, ana logous to those observed in other species [Reilh, 1968a, b: Nagai, 1970: Takuma and Nagai, 1971: Weinstock, 1972Weinstock and Leblond, 1974], The Golgi apparatus consisted of more or less four parallel stacks. Vesicles, probably derived from denuded regions of the rough endoplasmic reticulum, were noted on the forming face of the Golgi apparatus.…”

Section: Discussionmentioning

confidence: 99%

“…Takuma and Nagai, 1971;Si sea and Provenza, Although it has been reported that Korff's 1972: Weinstock, 1972Katchburian, 1973: fibers extend from the subodontoblastic layers Larsson and Bloom, 1973;Larsson, 1974; to the predentin Scott, 1958, 1959;Weinstock andLeblond, 1974] as well as those Bevelander and Nakahara, 1966;Frank, 1968;Reirh, 1968b] and that they are physically separated from the cell membrane of the distal aspect of the odontoblast by a large distance, in the present study the distal aspect of the odontoblast was in close proximity to, and at times contiguous with, KorlT's libers. Further more, aperiodic fibers between the odonto blastic processes were noted to be attached to KorlT's libers.…”

Section: Discussionmentioning

confidence: 99%

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A fine-structural analysis of mouse molar odontoblast maturation

Gartner¹,

Seibel²,

Hiatt³

et al. 1979

Cells Tissues Organs

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The first mandibular molars of the Swiss albino mice, 1 through 4 days of age, were fixed in glutaraldehyde or Karnovsky’s fixative. The tissues were postfixed in Os04, dehydrated and embedded in Epon. The prepolarizing, polarizing and secretory odontoblasts were described. The prepolarizing cells, located in the vicinity of the cervical loop, were mesenchymal-like in morphology. The cells of the polarizing stage possessed organelles indicative of protein synthesis. The nucleus was located proximally. Aperiodic fibers were evident in the wide basement membrane. The secretory odontoblasts were long, slender, polarized cells closely adjoining one another. Each odontoblast possessed six morphologically discernible regions: (1) an infranuclear region, limited in size and containing few cellular organelles; (2) a nuclear region, housing the oval nucleus and a few associated lamellae of rough endoplasmic reticulum as well as a limited number of mitochondria; (3) a supranuclear rough endoplasmic reticulum region, possessing an abundance of these organelles as well as some mitochondria and secretory vesicles; (4) a Golgi region, occupying the middle third of the cell, housing the elements of an extensive Golgi apparatus which was surrounded by peripherally located profiles of rough endoplasmic reticulum; additionally, this region contained smooth endoplasmic reticulum, mitochondria, numerous secretory granules and vesicles and occasional intracellular collagen fibers; (5) an apical rough endoplasmic reticulum region, containing a rough endoplasmic reticulum component that was less extensive than its supranuclear counterpart; in addition, this region was the one richest in mitochondria and contained a plethora of secretory vesicles and granules; (6) the odontoblastic process, a region mostly void of organelles, containing various secretory products, some of which appeared to be in the process of being released extracellularly into the surrounding dentin matrix.

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Section: Discussionsupporting

confidence: 71%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

A fine-structural analysis of mouse molar odontoblast maturation

Gartner¹,

Seibel²,

Hiatt³

et al. 1979

Cells Tissues Organs

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“…Some authors (REITH, 1968;FRANK and FRANK, 1969;WEINSTOCK, 1972) support a secretion mechanism as in the exocrine cells in which protein molecules are transported from granular endoplasmic reticulum to the Golgi complex and released to the extracellular space (WARSHAWSKY et al, 1963;CARO and PALADE, 1964;REDMAN et al, 1966;JAMIESON andPALADE, 1967, 1968a, b), while others suggest another pathway for fibrous precursors to the extracellular space (ROHR, 1965;ROSS and BENDITT, 1965, COOPER and PROCKOP, 1968, SALPETER, 1968. Either hypothesis lacks direct proof, but it is agreed that those cells which have a large amout of granular endoplasmic reticulum and a prominent Golgi complex represent the main source of fibrous proteins (PORTER and PAPPAS, 1959;KARRER, 1960;GOLDBERG and GREEN, 1964;ROSS andBENDITT, 1964, 1965).…”

Section: Discussionmentioning

confidence: 99%

Fine Structure of the Reticular Cells in the Rat Spleen, with Special Reference to Their Fibro-Muscular Features

Saito

1977

Arch. Histol. Jap., Arch. Histol. Jpn

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“…1982;1985] or vinblastin [Miake, 1981] or normal conditions [Nagai. 1970: Weinstock. 1972: Wein stock and Leblond.…”

Section: Discussionmentioning

confidence: 99%

Ultrastructural Observations on the Intraodontoblastic Collagen Fibrils of the Mouse Tooth Germs

Ishizeki¹,

Sakakura²,

Nawa³

1987

Cells Tissues Organs

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We examined electron-microscopically and histochemically the ultrastructural features of the intraodontoblastic collagen fibrils of the mouse. These collagen fibrils were most common in secreting odontoblasts (pre-odontoblasts) of the maturating stages. In such cells they were most numerous at the peripheral zone of the Golgi apparatus, and were sometimes seen in odontoblastic processes. Intraodontoblastic collagen fibrils also had morphological variations including a banded structure enclosed by limiting membranes of vacuoles, fusion with primary lysosomes, and an electron-dense material covering with a structure that was not banded. Study of acid phosphatase activity showed that these structural changes were caused by the degradation of intraodontoblastic collagen fibrils by lysosomes. The results of studies of the permeation of lanthanum nitrate and the alkaline phosphatase reaction showed that these collagen fibrils were separate from the extracellular matrix and that there was no phagocytosis of the odontoblasts.

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Collagen formation ? observations on its intracellular packaging and transport

Cited by 78 publications

References 28 publications

A fine-structural analysis of mouse molar odontoblast maturation

A fine-structural analysis of mouse molar odontoblast maturation

Fine Structure of the Reticular Cells in the Rat Spleen, with Special Reference to Their Fibro-Muscular Features

Ultrastructural Observations on the Intraodontoblastic Collagen Fibrils of the Mouse Tooth Germs

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