The present article surveys the changes in the time allocated for the four disciplines in the anatomical sciences in the medical curricula of allopathic medical schools in the United States from 1967-2001. The results indicate that there was a great reduction in the laboratory portions, but not in the lecture portions of Gross Anatomy, Histology, Neuroanatomy, and Embryology. The greatest time reduction overall for the disciplines occurred between 1967-1973 (502 to 387 hr), followed by the time reduction between 1982-1995 (380 to 329 hr).
The ultraviolet (UV-)sensitivity of the human cytomegalovirus (HCMV) genes coding for very early complement fixing and early antigens in human embryonic fibroblasts (HEF) and mouse embryonic fibroblasts (MEF) and the relation of these genes to the ability of the virus to stimulate host cell DNA synthesis were investigated. After 14 minutes of UV-irradiation of the virus inoculum only the very early complement fixing nuclear antigen (CMNA) developed in the HEF cells and only the early cytoplasmic antigen(s) was present in the MEF. In both HEF and MEF, host cell DNA synthesis was stimulated. We conclude that the ability of HCMV to stimulate host DNA synthesis is an early function of the viral genome and shows a high resistance to UV-irradiation. There is no direct correlation, however, between the ability of the virus to stimulate host cell DNA synthesis and the genes which code for the CMNA or for early cytoplasmic antigens.
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