Collagen hydrolysate based collagen/hydroxyapatite composite materials

Ficai, Anton; Kaya, Mădălina Georgiana Albu; Birsan, M.; Sönmez, Maria; Ficai, Denisa; Trandafir, Viorica; Andronescu, Ecaterina

doi:10.1016/j.molstruc.2012.12.052

Cited by 55 publications

(39 citation statements)

References 23 publications

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“…And, the peaks at 559 and 1030 cm -1 were attributed to the HPO 4 band that originated from the OCP structure. The P-OH band, characteristic of the HPO 4 2-group, was observed at 877 cm -1 , confirming the presence of the OCP structure. Figure 3a(2) shows the FT-IR spectrum of the CaP/CS coating on cp-Ti after postNaOH treatment.…”

Section: Methodsmentioning

confidence: 61%

“…A strong carbonate band was observed at 1072 cm -1 . The ν1 of carbonate apatite overlapped one band of the ν2 of PO 4 3-due to bonded chain between CS and CaP.…”

Section: Methodsmentioning

confidence: 96%

“…The Raman spectra of CaP/CS coating in the post-NaOH treated specimen (Figure 3b (2)) were dominated by a strong band at around 960 cm -1 that is derived from the symmetric stretching mode (ν1) of the phosphate group. In the spectrum, the bands at 420 and 593 cm -1 corresponded to the ν2 bending vibration and ν4 modes of the PO 4 3-group were displayed, respectively. A strong carbonate band was observed at 1072 cm -1 .…”

Section: Methodsmentioning

confidence: 99%

“…Thus, the use of a hybrid composite that comprises natural biopolymer and calcium phosphate most aptly resembles the morphology and properties of natural bone. Natural biomaterials such as collagen, chitosan, gelatin, and hyaluronic acid are currently tested as coating materials of implants for the regeneration of damaged and diseased tissues on the basis of their biocompatibility and mechanical properties [4][5][6][7]. Collagen and gelatin from partial hydrolysis of collagen are biocompatible, non-cytotoxic, with an ability to support cellular growth, and can be processed into a variety of forms.…”

Section: Introductionmentioning

confidence: 99%

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Biomimetic fabrication of calcium phosphate/chitosan nanohybrid composite in modified simulated body fluids

Park¹,

Kim²,

Hwang³

et al. 2017

Express Polym. Lett.

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Abstract. In this study, nucleation and growth of bone-like hydroxyapatite (HAp) mineral in modified simulated body fluids (m-SBF) were induced on chitosan (CS) substrates, which were prepared by spin coating of chitosan on Ti substrate. The m-SBF showed a two fold increase in the concentrations of calcium and phosphate ions compared to SBF, and the postNaOH treatment provided stabilization of the coatings. The calcium phosphate/chitosan composite prepared in m-SBF showed homogeneous distribution of approximately 350 nm-sized spherical clusters composed of octacalcium phosphate (OCP; Ca 8 H 2 (PO 4 ) 6 ·5H 2 O) crystalline structure. Chitosan provided a control over the size of calcium phosphate prepared by immersion in m-SBF, and post-NaOH treatment supported the binding of calcium phosphate compound on the Ti surface. Post-NaOH treatment increased hydrophilicity and crystallinity of carbonate apatite, which increased its potential for biomedical application.

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Section: Methodsmentioning

confidence: 61%

“…A strong carbonate band was observed at 1072 cm -1 . The ν1 of carbonate apatite overlapped one band of the ν2 of PO 4 3-due to bonded chain between CS and CaP.…”

Section: Methodsmentioning

confidence: 96%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Biomimetic fabrication of calcium phosphate/chitosan nanohybrid composite in modified simulated body fluids

Park¹,

Kim²,

Hwang³

et al. 2017

Express Polym. Lett.

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“…Collagen protein is one of the major components of connective and bone tissues (Cuneo et al, 2010) being one of the mostly used biomaterials due to its excellent biocompatibility, biodegradability and weak antigenicity, well established structure, biologic characteristics and to the way it interacts with the body, being known by the body as one of its constituent and not as an unknown material (Albu et al, 2011;Ficai et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Investigation of Dialdehyde Corn Starch as Crosslinking Agent in Collagen-Based Wound Dressing Materials

Ozkan¹,

Özgünay²,

Marin³

et al. 2016

The International Conference on Advanced Materials and Systems

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Collagen is the most commonly used tissue-derived natural polymer. Collagen gels are widely used in wound dressing materials due to their good degradability, poor antigenicity, excellent biocompatibility and unique fibril forming properties. But, poor mechanical properties of physically formed collagen gels limit their usage in biomedical fields. However, collagen gels can be stabilized by using cross-linkers. In recent years, use of crosslinking agents obtained from biodegradable, low toxic, abundant, inexpensive and renewable sources in wound dressing materials for stabilization of collagen gels has become important. In the present study use of starch as a crosslinking agent in stabilization of collagen gels was investigated. For this purpose native starch was modified via oxidation of corn starch by NaIO4 in order to obtain dialdehyde starch. Then, the degree of substitution and swelling index of oxidized starches were determined and the starch samples were characterized by Fourier transforms infrared (FT-IR) spectroscopy and Scanning Electron Microscopy (SEM). Collagen gels were crosslinked with dialdehyde starch samples for preparing wound dressing materials. The collagen gel composites were lyophilized and sponge forms were obtained. They were characterized by water uptake capacity and enzymatic degradation. The results revealed that, dialdehyde corn starch can be used successively in collagen-based wound dressing materials as crosslinking agent.

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Organic–inorganic collagen/iota‐carrageenan/hydroxyapatite hybrid membranes are bioactive materials for bone regeneration

Nogueira

Maniglia

Blácido

et al. 2019

J of Applied Polymer Sci

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This study aimed to produce biomembranes with controlled degradability for application in bone regeneration in order to stimulate biological reactions necessary to improve bone formation. Hydrogels were prepared by dissolving hydrolyzed collagen (HC) and iota‐carrageenan (ι‐Carr) in aqueous mixtures containing CaCl2 and H3PO4. A rise in pH by exposure to NH3(g) caused mineral precipitation into the hydrogel. Subsequently, the membranes were fabricated by solvent casting. Infrared spectroscopy and X‐ray diffraction attested hydroxyapatite formation. The crystallite size was close to 12 nm, which was smaller than the size reported for human bone apatite. The membranes induced bone‐like apatite precipitation in simulated body fluid. The carrageenan content modulated the membrane mechanical behavior. Membranes with controlled degradability were obtained by using higher amount of this polysaccharide. These membranes were able to release HC in physiological conditions. The surface properties were evaluated in terms of wettability and surface energy (γS) by means of contact angle (θc) measurements. Low θc (8.5–16.8) indicated that the hybrid membranes were hydrophilic, while higher γS values, around 70.6 mJ.m−2, could favor biomolecule incorporation into the surface. Our data set evidenced that these materials could potentially be used as a temporary guided tissue regeneration membrane with the possibility of inducing bone regeneration. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 48004.

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Collagen hydrolysate based collagen/hydroxyapatite composite materials

Cited by 55 publications

References 23 publications

Biomimetic fabrication of calcium phosphate/chitosan nanohybrid composite in modified simulated body fluids

Biomimetic fabrication of calcium phosphate/chitosan nanohybrid composite in modified simulated body fluids

Investigation of Dialdehyde Corn Starch as Crosslinking Agent in Collagen-Based Wound Dressing Materials

Organic–inorganic collagen/iota‐carrageenan/hydroxyapatite hybrid membranes are bioactive materials for bone regeneration

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