Collagen matrices from sponge to nano: new perspectives for tissue engineering of skeletal muscle

Beier, Justus P.; Klumpp, Dorothee; Rudisile, Markus; Dersch, Roland; Wendorff, Joachim H.; Bleiziffer, Oliver; Arkudas, Andreas; Polykandriotis, Elias; Horch, Raymund E.; Kneser, Ulrich

doi:10.1186/1472-6750-9-34

Cited by 92 publications

(69 citation statements)

References 38 publications

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“…The presence of collagen fibers promotes the migration, proliferation, and differentiation of myoblasts, as well as myogenesis in stem cells, supposedly by creating a biologically, structurally, and biomechanically favorable environment. [46][47][48][49] Myosins bind to actin filaments within the skeletal muscle cells and play a key role in muscle contraction. Troponin molecules play a key role in the relaxation and contraction of muscles by controlling the interaction between tropomyosin and calcium channels, wherein tropomyosin lies in the actin filaments.…”

Section: Discussionmentioning

confidence: 99%

Nanometer-thin TiO2 enhances skeletal muscle cell phenotype and behavior

Ishizaki

Sugita²,

Iwasa³

et al. 2011

IJN

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Background:The independent role of the surface chemistry of titanium in determining its biological properties is yet to be determined. Although titanium implants are often in contact with muscle tissue, the interaction of muscle cells with titanium is largely unknown. This study tested the hypotheses that the surface chemistry of clinically established microroughened titanium surfaces could be controllably varied by coating with a minimally thin layer of TiO 2 (ideally pico-to-nanometer in thickness) without altering the existing topographical and roughness features, and that the change in superficial chemistry of titanium is effective in improving the biological properties of titanium. Methods and results: Acid-etched microroughened titanium surfaces were coated with TiO 2 using slow-rate sputter deposition of molten TiO 2 nanoparticles. A TiO 2 coating of 300 pm to 6.3 nm increased the surface oxygen on the titanium substrates in a controllable manner, but did not alter the existing microscale architecture and roughness of the substrates. Cells derived from rat skeletal muscles showed increased attachment, spread, adhesion strength, proliferation, gene expression, and collagen production at the initial and early stage of culture on 6.3 nm thick TiO 2 -coated microroughened titanium surfaces compared with uncoated titanium surfaces. Conclusion: Using an exemplary slow-rate sputter deposition technique of molten TiO 2 nanoparticles, this study demonstrated that titanium substrates, even with microscale roughness, can be sufficiently chemically modified to enhance their biological properties without altering the existing microscale morphology. The controllable and exclusive chemical modification technique presented in this study may open a new avenue for surface modifications of titaniumbased biomaterials for better cell and tissue affinity and reaction.

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Section: Discussionmentioning

confidence: 99%

Nanometer-thin TiO2 enhances skeletal muscle cell phenotype and behavior

Ishizaki

Sugita²,

Iwasa³

et al. 2011

IJN

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“…As an alternative strategy to in situ recruitment of cells, ECM has been commonly used as a delivery vehicle, where myogenic progenitor cells are seeded on a scaffold -which is then transferred to the in vivo site of interest (Beier et al, 2009;Borschel et al, 2004;Liao and Zhou, 2009;Merritt et al, 2010;Moon du et al, 2008;Vindigni et al, 2004). However, these techniques generally produce muscle tissue with minimal contractile forces since the amount of scaffold material is high and can inhibit myoblast fusion.…”

Section: Nj Turner Et Al Biologic Scaffolds For Tissue Repairmentioning

confidence: 99%

“…However, these techniques generally produce muscle tissue with minimal contractile forces since the amount of scaffold material is high and can inhibit myoblast fusion. Many approaches use a gel-based construct of mainly collagen, laminin or fibrin that do not necessarily replicate the complex ultrastructure of native tissue (Beier et al, 2009;Huang et al, 2005;Matsumoto et al, 2007;Rowlands et al, 2007;Vandenburgh et al, 1988).…”

Section: Nj Turner Et Al Biologic Scaffolds For Tissue Repairmentioning

confidence: 99%

Biologic scaffolds for musculotendinous tissue repair

Turner

Badylak²

2013

eCM

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Traumatic injuries to the musculoskeletal system are common events and volumetric muscle loss (VML) is no longer a rare occurrence. Surgical intervention is typically the only option for restoration of partial function. Surgical intervention for VML however does not regenerate the lost tissue and typically results in alterations of both the anatomy and biomechanics at the site of injury. Non-traditional approaches to the restoration of functional musculoskeletal tissue, including those provided by tissue engineering and regenerative medicine strategies, become viable alternative therapies when the expected outcome is bleak. One such strategy involves the delivery of constructive cues and modulation of the micro-environmental niche via biologic scaffold materials. These materials ideally retain the native structure and composition of the extracellular matrix of the tissue from which they are derived. Some of the recent advances in the use of biologic scaffolds to target key stages of the musculotendinous repair process and promote the restoration of functional tissue are described herein.

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“…Tissue engineering has the potential to produce tissues and organs de novo. The required pore sizes for bone, muscle and skin are 100-300 μm [5], 100-200 μm [6,7], and 20-120 μm [8], respectively. The tissue engineering materials for scaffold should be biocompatible, biodegradable, and mechanically stable, which depends on the material's chemistry, solubility, structure, shape, hydrophobicity/ hydrophilicity, surface energy, water absorption, molecular weight.…”

Section: Introductionmentioning

confidence: 99%

Comparative study of chitosan and chitosan–gelatin scaffold for tissue engineering

2017

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A number of orthopedic disorders and bone defect issues are solved by scaffold-based therapy in tissue engineering. The biocompatibility of chitosan (polysaccharide) and its similarity with glycosaminoglycan makes it a bone-grafting material. The current work focus on the synthesis of chitosan and chitosan-gelatin scaffold for hard tissue engineering. The chitosan and chitosan-gelatin scaffold have shown improved specific surface area, density, porosity, mechanical properties, biodegradability and absorption. These scaffolds can lead to the development or artificial fabrication of hard tissue alternates. The porous scaffold samples were prepared by freeze-drying method. The microstructure, mechanical and degradable properties of chitosan and chitosan-gelatin scaffolds were analyzed and results revealed that the scaffolds prepared from chitosan-gelatin can be utilized as a useful matrix for tissue engineering.

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Collagen matrices from sponge to nano: new perspectives for tissue engineering of skeletal muscle

Cited by 92 publications

References 38 publications

Nanometer-thin TiO2 enhances skeletal muscle cell phenotype and behavior

Nanometer-thin TiO2 enhances skeletal muscle cell phenotype and behavior

Biologic scaffolds for musculotendinous tissue repair

Comparative study of chitosan and chitosan–gelatin scaffold for tissue engineering

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