Collagen methionine sulfoxide and glucuronidine/LW-1 are markers of coronary artery disease in long-term survivors with type 1 diabetes. The Dialong study

Holte, Kari Anne; Svanteson, Mona; Hanssen, Kristian F.; Sveen, Kari Anne; Seljeflot, Ingebjørg; Solheim, Svein; Sell, David R.; Monnier, Vincent M.; Berg, Tore Julsrud

doi:10.1371/journal.pone.0233174

Cited by 9 publications

(9 citation statements)

References 40 publications

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“…Hence, it is indispensable to seek a convenient and noninvasive detection method [12]. Relevant studies have shown that CML, sRAGE, and esRAGE participate in the development of atherosclerosis [13,14], but few scholars shared the experience of evaluating the correlation among CML, sRAGE, and esRAGE and the measure of atherosclerosis in CHD. e outcome of this research found out that CML, sRAGE, and esRAGE were closely associated by the extent of atherosclerosis in CHD, and the reasons are analyzed as follows.…”

Section: Discussionmentioning

confidence: 99%

Correlation Analysis of CML, sRAGE, and esRAGE and the Measure of Atherosclerosis of Coronary Heart Disease

Liu

Zhang

et al. 2022

Computational Intelligence and Neuroscience

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Objective. To investigate the correlation between CML, sRAGE, and esRAGE and the measure of atherosclerosis of coronary heart disease. Methods. From June 2019 to December 2021, there were 100 patients in all suffering from coronary heart disease (CHD) selected as the observation group. On the basis of Gensini score, they were divided into mild group (Gensini score < 12 points), moderate group (12 points ≤ Gensini score ≤60 points), and severe group (Gensini score > 60). Apart from that, 50 normal people staying in our hospital for physical examination were chosen as the control group in the meantime. N in each group was detected and compared ε-Carboxymethyl lysine (CML), soluble advanced glycation end product receptor (sRAGE), and endogenous secretory advanced glycation end product receptor (esRAGE). Pearson correlation coefficient was adapted to assay the relevance between CML, sRAGE, and esRAGE, as well as the degree of atherosclerosis in CHD. Receiver operator characteristic (ROC) curve was applied to during the evaluation of the diagnosis of CML, sRAGE, and esRAGE, as well as their combined detection of severe atherosclerosis in CHD. Results. In contrast with the control group, the level of serum CML together with sRAGE in the observation group was considerably elevated, while the level of esRAGE appeared in a downward trend ( P < 0.05). The level of serum CML and sRAGE was directly proportional to the measure of atherosclerosis in CHD, while the level of esRAGE was inversely proportional to the measure of atherosclerosis in CHD ( P < 0.05). That is to say that serum CML and sRAGE were positive in matter of the measure of atherosclerosis in CHD, while esRAGE negatively appertains to the measure of atherosclerosis in CHD ( P < 0.05). Serum CML, sRAGE, and esRAGE could effectively diagnose severe atherosclerosis in CHD, and the combined detection sensitivity (89.79%), specificity (77.16%), accuracy (86.12%), positive predictive value (86.63%), negative predictive value (88.59%), and area under ROC curve (AUC) (0.924) were higher ( P < 0.05). Conclusion. CML and sRAGE, as well as esRAGE, are bound up with the degree of atherosclerosis in CHD, which is conducive to clinical diagnosis and treatment.

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Section: Discussionmentioning

confidence: 99%

Correlation Analysis of CML, sRAGE, and esRAGE and the Measure of Atherosclerosis of Coronary Heart Disease

Liu

Zhang

et al. 2022

Computational Intelligence and Neuroscience

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“…This is consistent with our previous finding that Met-sulfoxide and 5-oxoproline declined during the aggravation of IL1-β-induced HGF inflammation by TiO 2 nanoparticles ( Supplementary Figure S2A,B , cited from [ 15 ]). Since Met-sulfoxide [ 23 , 24 , 25 ] and 5-oxoproline [ 26 , 27 , 28 ] are well-known markers reflecting oxidative stress, SE might have induced the cells to fight against oxidative stress.…”

Section: Discussionmentioning

confidence: 99%

Multi-Omics Analysis of Anti-Inflammatory Action of Alkaline Extract of the Leaves of Sasa sp.

Sakagami

Nakatani

Enomoto

et al. 2021

JCM

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Efficient utilization of alkaline extracts of several plants for the treatment of oral diseases has been reported. To investigate the mechanism of anti-inflammatory activity of alkaline extract of the leaves of Sasa sp. (SE), multi-omics analysis using metabolomics and DNA array was performed. Human gingival fibroblasts (HGFs) were treated for IL-1β to induce inflammation (detected by PGE2 production in culture medium) in the presence or absence of SE. Both IL-1β and SE showed slight hormetic growth stimulation against HGF. SE inhibited PGE2 production dose- and time-dependently. Its inhibitory action was more pronounced by first treating the cells with SE, rather than with IL-1β. At 3 h after IL-1β treatment, 18 amino acids (except cysteine and glutamic acid), total glutathione (GSH, GSSG, Cys-GSH disulfide), Met-sulfoxide, 5-oxoproline, and SAM declined, whereas DNA expressions of AKT, CASP3, and CXCL3 were elevated. These changes were reversed by simultaneous treatment with SE. The present study suggests that the anti-inflammatory action of SE is mediated via various metabolic pathways for cell survival, apoptosis, and leukocyte recruitment.

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“…Moreover, adding plasma endostatin to a basic model constructed with conventional factors significantly improved risk stratification in this population [ 46 ▪ ]. The collagen advanced glycation end product glucuronidine/LW-1 found in skin, rather than in the circulation, was also associated with established coronary heart disease and calcified plaque volume in diabetic patients [ 47 ▪ ].…”

Section: Collagen Structure and Plaque Integritymentioning

confidence: 99%

Extracellular matrix: paving the way to the newest trends in atherosclerosis

Gialeli

Shami

Gonçalves

2021

Current Opinion in Lipidology

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Purpose of review The extracellular matrix (ECM) is critical for all aspects of vascular pathobiology. In vascular disease the balance of its structural components is shifted. In atherosclerotic plaques there is in fact a dynamic battle between stabilizing and proinflammatory responses. This review explores the most recent strides that have been made to detail the active role of the ECM – and its main binding partners – in driving atherosclerotic plaque development and destabilization. Recent findings Proteoglycans-glycosaminoglycans (PGs-GAGs) synthesis and remodelling, as well as elastin synthesis, cross-linking, degradation and its elastokines potentially affect disease progression, providing multiple steps for potential therapeutic intervention and diagnostic targeted imaging. Of note, GAGs biosynthetic enzymes modulate the phenotype of vascular resident and infiltrating cells. In addition, while plaque collagen structure exerts very palpable effects on its immediate surroundings, a new role for collagen is also emerging on a more systemic level as a biomarker for cardiovascular disease as well as a target for selective drug-delivery. Summary The importance of studying the ECM in atherosclerosis is more and more acknowledged and various systems are being developed to visualize, target and mimic it.

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Collagen methionine sulfoxide and glucuronidine/LW-1 are markers of coronary artery disease in long-term survivors with type 1 diabetes. The Dialong study

Cited by 9 publications

References 40 publications

Correlation Analysis of CML, sRAGE, and esRAGE and the Measure of Atherosclerosis of Coronary Heart Disease

Correlation Analysis of CML, sRAGE, and esRAGE and the Measure of Atherosclerosis of Coronary Heart Disease

Multi-Omics Analysis of Anti-Inflammatory Action of Alkaline Extract of the Leaves of Sasa sp.

Extracellular matrix: paving the way to the newest trends in atherosclerosis

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