Collagen of the normal and the varicose human saphenous vein: A biochemical study

Maurel, E.; Azéma, Christine; Deloly, J.; Bouissou, H

doi:10.1016/0009-8981(90)90004-c

Cited by 43 publications

(26 citation statements)

References 17 publications

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“…Measurement of the content in collagen has yielded conflicting results. Increases [7, 8], decreases [2, 9]or unchanged [3, 10]levels of collagen have been reported in varicose veins. Most studies measured only the total collagen content.…”

Section: Introductionmentioning

confidence: 99%

Imbalance in the Synthesis of Collagen Type I and Collagen Type III in Smooth Muscle Cells Derived from Human Varicose Veins

et al. 2001

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Varicose veins have a thickening wall. Their smooth muscle cells are disorganized as regards proliferation and production of extracellular matrix protein. An imbalance between the synthesis of collagen type I protein (collagen I) and collagen type III protein (collagen III) could explain the lack of elasticity of varicose veins. Therefore, collagen synthesis was compared in the media and in cultured smooth muscle cells derived from human control and varicose saphenous veins. An increase in total collagen synthesis was observed in the media and in smooth muscle cells derived from varicose veins. This augmentation was due to an overproduction of collagen I in cultured cells from varicose veins consistent with an increase in the release of collagen I metabolites in the media. A concomitant decrease in collagen III was observed in cultures of smooth muscle cells from varicose veins. The increase in the synthesis of collagen I in cells from varicose veins was correlated with an overexpression of the gene since mRNAs for collagen I were augmented without change in mRNA-half-life. This augmentation in the synthesis of collagen I was reduced by the addition of exogenous collagen III in cultures from varicose veins. These findings suggest a dysregulation of the synthesis of collagen I and III in smooth muscle cells derived from varicose veins.

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Section: Introductionmentioning

confidence: 99%

Imbalance in the Synthesis of Collagen Type I and Collagen Type III in Smooth Muscle Cells Derived from Human Varicose Veins

et al. 2001

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“…Morphologically, fibrosis is the primary lesion of the varicose process [13, 14]. In the present study the collagen content was equal among the groups (table 1).…”

Section: Discussionmentioning

confidence: 52%

“…Two studies have investigated the viscoelastic properties and collagen content of the long saphenous vein in normal and varicose veins and found significant structural changes in the latter [13, 14]. The studies did not take age into account, but age plays a major role because ID (diameter) declines with age (fig.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Biomechanical Properties of the Internal Spermatic Vein in the Normal Population and Patients with Left-Sided Varicocele Testis

Lund

Ernst²,

Sørensen³

et al. 1998

European Urology

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“…These proteins and glycoproteins were examined in patients with varicose veins and certain changes were identified. Although there are findings that show a decreased amount of collagen (7,8), the amount of collagen generally increases (9)(10)(11)(12)(13)(14)(15) and this situation is even observed in cellular cultures (15)(16)(17). The increase in collagen occurs both in the intima (13) and in the media (12,18).…”

Section: Introductionmentioning

confidence: 99%

Does extracellular matrix of the varicose vein wall change according to clinical stage?

Demirkıran¹,

Köksoy

Heper

et al. 2014

UCD

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Objective:The etiology and pathophysiology of chronic venous disease is not fully understood. This study aimed to determine the variation of the extracellular matrix proteins in varicose vein wall according to clinical stage. Material and Methods:Forty varicose and 10 control veins were sampled from the saphenofemoral junction. The Clinical Etiologic Anatomic Pathophysiologic (CEAP) classification was used in patients with varicose veins. Samples were stained with hematoxylin-eosin, Masson's trichrome, EVG (Elastica-van Gieson) stain and with laminin, fibronectin, tenascin antibodies. Stained samples were examined immuno-histochemically. Changes in extracellular matrix were determined semi-quantitatively using light microscopy. Results:It was observed that in the early stages (C2-C3) of chronic venous disease, fibrosis is increased in the intima and media layers, with fragmentation in lamina elastica interna, and increased tenascin expression in the intima layer. In advanced stages (C4-C6), the accumulation of tenascin in the intima continued along with fibrosis in the media layer, the thickness of the media layer increased and fibronectin deposition was observed. Conclusion:This study showed that changes first occur in the intima during the early stages of the disease with addition of alterations in the media layer at later stages.

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Collagen of the normal and the varicose human saphenous vein: A biochemical study

Cited by 43 publications

References 17 publications

Imbalance in the Synthesis of Collagen Type I and Collagen Type III in Smooth Muscle Cells Derived from Human Varicose Veins

Imbalance in the Synthesis of Collagen Type I and Collagen Type III in Smooth Muscle Cells Derived from Human Varicose Veins

Biomechanical Properties of the Internal Spermatic Vein in the Normal Population and Patients with Left-Sided Varicocele Testis

Does extracellular matrix of the varicose vein wall change according to clinical stage?

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