Collagen stabilization using ionic liquid functionalised cerium oxide nanoparticle

Inbasekar, Chandrasekar; Fathima, Nishter Nishad

doi:10.1016/j.ijbiomac.2019.12.271

Cited by 14 publications

(11 citation statements)

References 14 publications

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“…GNF@ZnO composites were obtained by synthesis of ZnO nanoparticles (ZnO NPs) on previously prepared gelatin nanofibers pieces (~2.25 cm 2 ). ZnO NPs were prepared using an adapted sol-gel procedure based on the work of W. J. E. Beek et al [15]. The procedure used for the preparation of GNF@ZnO was as follows: 13.4 mmol of zinc acetate dihydrate (Zn(CH 3 COO) 2 × 2H 2 O)) was dissolved in 125 mL methanol (MeOH) at constant temperature (60 • C) with vigorous stirring.…”

Section: Gnf@zno Composite Synthesismentioning

confidence: 99%

“…Several polymeric materials, such as collagen and gelatin, have been investigated in the past due to their low toxicity, excellent film forming ability, abundancy, high biocompatibility, and biodegradability in physiological environments [15,16]. Gelatin is one of the most studied biopolymers, and it is widely used in food (mainly as biodegradable packaging), cosmetics, pharmaceutical, and medical applications.…”

Section: Introductionmentioning

confidence: 99%

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Fabrication of Gelatin-ZnO Nanofibers for Antibacterial Applications

et al. 2020

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In this study, GNF@ZnO composites (gelatin nanofibers (GNF) with zinc oxide (ZnO) nanoparticles (NPs)) as a novel antibacterial agent were obtained using a wet chemistry approach. The physicochemical characterization of ZnO nanoparticles (NPs) and GNF@ZnO composites, as well as the evaluation of their antibacterial activity toward Gram-positive (Staphyloccocus aureus and Bacillus pumilus) and Gram-negative (Escherichia coli and Pseudomonas fluorescens) bacteria were performed. ZnO NPs were synthesized using a facile sol-gel approach. Gelatin nanofibers (GNF) were obtained by an electrospinning technique. GNF@ZnO composites were obtained by adding previously produced GNF into a Zn2+ methanol solution during ZnO NPs synthesis. Crystal structure, phase, and elemental compositions, morphology, as well as photoluminescent properties of pristine ZnO NPs, pristine GNF, and GNF@ZnO composites were characterized using powder X-ray diffraction (XRD), FTIR analysis, transmission and scanning electron microscopies (TEM/SEM), and photoluminescence spectroscopy. SEM, EDX, as well as FTIR analyses, confirmed the adsorption of ZnO NPs on the GNF surface. The pristine ZnO NPs were highly crystalline and monodispersed with a size of approximately 7 nm and had a high surface area (83 m2/g). The thickness of the pristine gelatin nanofiber was around 1 µm. The antibacterial properties of GNF@ZnO composites were investigated by a disk diffusion assay on agar plates. Results show that both pristine ZnO NPs and their GNF-based composites have the strongest antibacterial properties against Pseudomonas fluorescence and Staphylococcus aureus, with the zone of inhibition above 10 mm. Right behind them is Escherichia coli with slightly less inhibition of bacterial growth. These properties of GNF@ZnO composites suggest their suitability for a range of antimicrobial uses, such as in the food industry or in biomedical applications.

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Section: Gnf@zno Composite Synthesismentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Fabrication of Gelatin-ZnO Nanofibers for Antibacterial Applications

et al. 2020

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“…These particles have potential use as a collagen crosslinking agent in vivo and for tissue engineering applications. [ 164 ]…”

Section: Biomedical Applicationsmentioning

confidence: 99%

“…These particles have potential use as a collagen crosslinking agent in vivo and for tissue engineering applications. [164] Ammonium ILs' nitrogen core positions them as unique compounds to solve stabilization issues for both enzymes as well as other therapeutic proteins. The formation of a protein-IL gel was shown using 2-hydroxyethyl ammonium formate and 𝜖-poly-llysine.…”

Section: -Methylimidazolium Hexafluorophosphate-based Ils ([Bmim][scn...mentioning

confidence: 99%

Recent Advances in Ionic Liquids in Biomedicine

2021

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The use of ionic liquids and deep eutectic solvents in biomedical applications has grown dramatically in recent years due to their unique properties and their inherent tunability. This review will introduce ionic liquids and deep eutectics and discuss their biomedical applications, namely solubilization of drugs, creation of active pharmaceutical ingredients, delivery of pharmaceuticals through biological barriers, stabilization of proteins and other nucleic acids, antibacterial agents, and development of new biosensors. Current challenges and future outlooks are discussed, including biocompatibility, the potential impact of the presence of impurities, and the importance of understanding the microscopic interactions in ionic liquids in order to design task-specific solvents.

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“…Meanwhile, TPU's mechanical and thermal properties are also enhanced dramatically upon CeNPs' introduction [53]. CeNPs acting as a crosslinking agent for collagen has invoked considerable interest as a potential modifier to increase protein thermal stability [54].…”

Section: Cerium Oxide Nanoparticles As a Modifier Of Polymer Propertiesmentioning

confidence: 99%

CeO2 Nanoparticle-Containing Polymers for Biomedical Applications: A Review

et al. 2021

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The development of advanced composite biomaterials combining the versatility and biodegradability of polymers and the unique characteristics of metal oxide nanoparticles unveils new horizons in emerging biomedical applications, including tissue regeneration, drug delivery and gene therapy, theranostics and medical imaging. Nanocrystalline cerium(IV) oxide, or nanoceria, stands out from a crowd of other metal oxides as being a truly unique material, showing great potential in biomedicine due to its low systemic toxicity and numerous beneficial effects on living systems. The combination of nanoceria with new generations of biomedical polymers, such as PolyHEMA (poly(2-hydroxyethyl methacrylate)-based hydrogels, electrospun nanofibrous polycaprolactone or natural-based chitosan or cellulose, helps to expand the prospective area of applications by facilitating their bioavailability and averting potential negative effects. This review describes recent advances in biomedical polymeric material practices, highlights up-to-the-minute cerium oxide nanoparticle applications, as well as polymer-nanoceria composites, and aims to address the question: how can nanoceria enhance the biomedical potential of modern polymeric materials?

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Collagen stabilization using ionic liquid functionalised cerium oxide nanoparticle

Cited by 14 publications

References 14 publications

Fabrication of Gelatin-ZnO Nanofibers for Antibacterial Applications

Fabrication of Gelatin-ZnO Nanofibers for Antibacterial Applications

Recent Advances in Ionic Liquids in Biomedicine

CeO2 Nanoparticle-Containing Polymers for Biomedical Applications: A Review

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