Collagen type IV in epithelial tumours of colon

Immunohistochemical and Histopathological Evaluation of 2,4-Dichlorophenoxyacetic Acid-Induced Changes in Rat Kidney Cortex

“…Briefly, paraffin sections were immersed in xylene overnight and incubated in methanol containing 1% H 2 O 2 to reduce endogenous peroxidase activity. Sections were kept in sodium citrate solution in the microwave oven at 90 Watt for 5 min and at 360 W for 15 min (Galbavý et al 2002). After washing in 0.2 M Tris-HCl including 0.5% Triton X, the sections were exposed to the mouse anti-fibronectin primary antibody (Dako A0245).…”

The Pil3 pilus ofStreptococcus gallolyticusbinds to intestinal mucins and to fibrinogen

“…3 Recent experimental data indicate that metabolic alterations associated to CRC may favor S. gallolyticus outgrowth in this environment. 46 In addition, physiological alterations occurring during CRC, such as the expression of mislocalized MUC5AC mucin [32][33][34] and displaced epithelium with exposed collagen IV, 47 could favor adhesion of S. gallolyticus through Pil3 and Pil1 pili respectively, and thereby explain the increased numbers of S. gallolyticus bacteria at these particular sites. CRC conditions may also increase the ability of S. gallolyticus to translocate through the epithelial barrier and reach the lamina propria.…”

Long‐term clinical outcomes after Streptococcus bovis isolation in asymptomatic blood donors in Hong Kong

“…S. bovis Biotype I ( S. gallolyticus ssp. gallolyticus ) strains, which are characterized by collagen I/IV binding, enable them to colonize collagen‐rich premalignant or malignant sites in the gastrointestinal tract …”

“…gallolyticus) strains, which are characterized by collagen I/IV binding, enable them to colonize collagen-rich premalignant or malignant sites in the gastrointestinal tract. 22 The study is limited by being retrospective in nature and hence it is difficult to investigate their causal and temporal relationship. Moreover, with relatively few confirmed cases, the importance of S. bovis subtype on colonic pathology remains controversial.…”