Collagen VI protects against neuronal apoptosis elicited by ultraviolet irradiation via an Akt/Phosphatidylinositol 3-kinase signaling pathway

Cheng, Irene H.; Lin, Ying; Hwang, Eric; Huang, Hui; Chang, Wen Hsin; Liu, Yuxin; Chao, Chih-Yeh

doi:10.1016/j.neuroscience.2011.03.057

Cited by 60 publications

(52 citation statements)

References 48 publications

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“…An anti-apoptotic role for ColVI in the nervous system has also been suggested owing to the effects of ultraviolet (UV) irradiation on cultured neurons. In that study, addition of ColVI to the culture medium rescued UV-induced apoptosis and limited dendrite shrinkage, and ColVI was found to mediate this protection by acting through the Akt and JNK pathways (Cheng et al, 2011). These observations provided new insights into the function of ColVI in the central nervous system and also provided new perspectives for the potential role of this ECM component in regulating neuronal survival processes.…”

Section: Nervous Systemmentioning

confidence: 74%

Collagen VI at a glance

Cescon

Gattazzo

Chen

et al. 2015

Journal of Cell Science

283

286

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Collagen VI represents a remarkable extracellular matrix molecule, and in the past few years, studies of this molecule have revealed its involvement in a wide range of tissues and pathological conditions. In addition to its complex multi-step pathway of biosynthesis and assembly that leads to the formation of a characteristic and distinctive network of beaded microfilaments in the extracellular matrix, collagen VI exerts several key roles in different tissues. These range from unique biomechanical roles to cytoprotective functions in different cells, including myofibers, chondrocytes, neurons, fibroblasts and cardiomyocytes. Indeed, collagen VI has been shown to exert a surprisingly broad range of cytoprotective effects, which include counteracting apoptosis and oxidative damage, favoring tumor growth and progression, regulating autophagy and cell differentiation, and even contributing to the maintenance of stemness. In this Cell Science at a Glance article and the accompanying poster, we present the current knowledge of collagen VI, and in particular, discuss its relevance in stemness and in preserving the mechanical properties of tissues, as well as its links with human disorders.

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Section: Nervous Systemmentioning

confidence: 74%

Collagen VI at a glance

Cescon

Gattazzo

Chen

et al. 2015

Journal of Cell Science

283

286

View full text Add to dashboard Cite

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“…Other SF secreted proteins can be categorized into ECM proteins associated with neurite initiation, growth and elongation, topographic guidance and protection from apoptosis, including FN, LAM, CTGF, CYR61, COL6A2, HSPG2, BGN, MGP and TNC65666768. Moreover, matricellular proteins like MMP2, TIMP, GDNF, PDGF, IGFBPs, THBS and complement factor C1R have been reported to promote neurite extension, adhesion, branching and differentiation as well as protection from neurotoxicity69707172.…”

Section: Discussionmentioning

confidence: 99%

Nerve regeneration by human corneal stromal keratocytes and stromal fibroblasts

Yam

Williams

Setiawan

et al. 2017

Sci Rep

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Laser refractive surgeries reshape corneal stroma to correct refractive errors, but unavoidably affect corneal nerves. Slow nerve regeneration and atypical neurite morphology cause desensitization and neuro-epitheliopathy. Following injury, surviving corneal stromal keratocytes (CSKs) are activated to stromal fibroblasts (SFs). How these two different cell types influence nerve regeneration is elusive. Our study evaluated the neuro-regulatory effects of human SFs versus CSKs derived from the same corneal stroma using an in vitro chick dorsal root ganglion model. The neurite growth was assessed by a validated concentric circle intersection count method. Serum-free conditioned media (CM) from SFs promoted neurite growth dose-dependently, compared to that from CSKs. We detected neurotrophic and pro-inflammatory factors (interleukin-8, interleukin-15, monocyte chemoattractant protein-1, eotaxin, RANTES) in SFCM by Bio-Plex Human Cytokine assay. More than 130 proteins in SFCM and 49 in CSKCM were identified by nanoLC-MS/MS. Proteins uniquely present in SFCM had reported neuro-regulatory activities and were predicted to regulate neurogenesis, focal adhesion and wound healing. Conclusively, this was the first study showing a physiological relationship between nerve growth and the metabolically active SFs versus quiescent CSKs from the same cornea source. The dose-dependent effect on neurite growth indicated that nerve regeneration could be influenced by SF density.

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“…Interaction of Collagen VI with NG2/CSPG4 resulted in increased cell motility in human glioma cell lines 47 . Col VI was found to protect the cells from apoptosis by activating Akt/PI3K pathway 48 and has been reported to be over expressed in breast cancer, ovarian cancer and gliomas 45, 49, 50 . Fibronectin, a glycoprotein with cell adhesive regions on it, plays a major role in the tumor cell migration and invasion through its interaction with partner proteins called integrins 51 .…”

Section: Discussionmentioning

confidence: 99%

Subventricular zone involvement in Glioblastoma – A proteomic evaluation and clinicoradiological correlation

Gollapalli

Ghantasala

Kumar

et al. 2017

Sci Rep

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Glioblastoma multiforme (GBM), the most malignant of all gliomas is characterized by a high degree of heterogeneity and poor response to treatment. The sub-ventricular zone (SVZ) is the major site of neurogenesis in the brain and is rich in neural stem cells. Based on the proximity of the GBM tumors to the SVZ, the tumors can be further classified into SVZ+ and SVZ−. The tumors located in close contact with the SVZ are classified as SVZ+, while the tumors located distantly from the SVZ are classified as SVZ−. To gain an insight into the increased aggressiveness of SVZ+ over SVZ− tumors, we have used proteomics techniques like 2D-DIGE and LC-MS/MS to investigate any possible proteomic differences between the two subtypes. Serum proteomic analysis revealed significant alterations of various acute phase proteins and lipid carrying proteins, while tissue proteomic analysis revealed significant alterations in cytoskeletal, lipid binding, chaperone and cell cycle regulating proteins, which are already known to be associated with disease pathobiology. These findings provide cues to molecular basis behind increased aggressiveness of SVZ+ GBM tumors over SVZ− GBM tumors and plausible therapeutic targets to improve treatment modalities for these highly invasive tumors.

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Collagen VI protects against neuronal apoptosis elicited by ultraviolet irradiation via an Akt/Phosphatidylinositol 3-kinase signaling pathway

Cited by 60 publications

References 48 publications

Collagen VI at a glance

Collagen VI at a glance

Nerve regeneration by human corneal stromal keratocytes and stromal fibroblasts

Subventricular zone involvement in Glioblastoma – A proteomic evaluation and clinicoradiological correlation

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