2016
DOI: 10.1016/j.jid.2016.02.002
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Collagen VII Half-Life at the Dermal-Epidermal Junction Zone: Implications for Mechanisms and Therapy of Genodermatoses

Abstract: The tissue half-life of proteins largely determines treatment frequency of non-gene-editing-based therapies targeting the cause of genodermatoses. Surprisingly, such knowledge is missing for a vast number of proteins involved in pathologies. The dermal-epidermal junction zone is believed to be a rather static structure, but to our knowledge no detailed analysis of the stability of proteins within this zone has been performed. Here, we addressed the in vivo half-life of collagen type VII using genetic ablation … Show more

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Cited by 43 publications
(27 citation statements)
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“…In accordance with the previously established half-life of collagen VII (38), tamoxifen treatment led to a significant loss of collagen VII in skin and spleen after >10 wk (Fig. 5 A and B).…”
Section: Collagen VII Is Indispensable For Retention Of Cochlin In Lysupporting
confidence: 90%
See 4 more Smart Citations
“…In accordance with the previously established half-life of collagen VII (38), tamoxifen treatment led to a significant loss of collagen VII in skin and spleen after >10 wk (Fig. 5 A and B).…”
Section: Collagen VII Is Indispensable For Retention Of Cochlin In Lysupporting
confidence: 90%
“…It is important to point out that this effect was achieved in absence of, and preceded, significant breach of skin integrity (Fig. 5A) (38).…”
Section: Collagen VII Is Indispensable For Retention Of Cochlin In Lymentioning
confidence: 87%
See 3 more Smart Citations